Yamamoto, Hiroyuki et al. published their research in Carbohydrate Research in 2019 | CAS: 582-52-5

Radiosynthesis of ¹⁸F-labeled D-allose was written by Yamamoto, Hiroyuki;Wada, Kenji;Toyohara, Jun;Tago, Tetsuro;Ibaraki, Masanobu;Kinoshita, Toshibumi;Yamamoto, Yuka;Nishiyama, Yoshihiro;Kudomi, Nobuyuki. And the article was included in Carbohydrate Research in 2019.Synthetic Route of C12H20O6 This article mentions the following:

Rare sugars are defined as monosaccharides that exist in nature but are only present in limited quantities. D-Allose is a rare sugar that has been reported to have some unique physiol. effects. The present study describes suitable synthetic procedures for novel rare sugars of D-allose that are ¹⁸F-labeled at the C-3 and C-6 positions and the preparation of the appropriate labeling precursors. The goal is to facilitate in vivo, noninvasive positron emission tomog. (PET) investigation of the behavior of rare sugar analogs of D-allose in organs. We found five precursors that were practical for labeling, three for 3-deoxy-3-[¹⁸F]fluoro-D-allose ([¹⁸F]3FDA) and two for 6-deoxy-6-[¹⁸F]fluoro-D-allose ([¹⁸F]6FDA). With manual operation synthesis, the highest radiochem. conversion rates were 75% for [¹⁸F]3FDA with a precursor of 1,2,4,6-tetra-O-acetyl-3-O-trifluoromethanesulfonyl-β-D-glucopyranose and 69% for [¹⁸F]6FDA with a precursor of 1,2,3,4-tetra-O-acetyl-6-O-trifluoromethanesulfonyl-β-D-allopyranose. Furthermore, the practical yields of [¹⁸F]3FDA and [¹⁸F]6FDA using an automated synthesizer were also investigated. Radiochem. yields of 67% and 49% were obtained for [¹⁸F]3FDA and [¹⁸F]6FDA, resp., in an automated synthesizer. As basic assessment of stability for use in PET scanning, high performance liquid chromatog. anal. showed no decomposition of [¹⁸F]3FDA and [¹⁸F]6FDA after up to 6 h in rabbit blood plasma. In the experiment, the researchers used many compounds, for example, (3aR,5S,6S,6aR)-5-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol (cas: 582-52-5Synthetic Route of C12H20O6).

(3aR,5S,6S,6aR)-5-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol (cas: 582-52-5) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Synthetic Route of C12H20O6

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem