Content determination of pharmaceutical adjuvant of sucrose octaacetate by HPLC was written by Feng, Feng-cou;Li, Shu-guang;Yu, Yue;Wu, Xiao-ou;Li, Jun. And the article was included in Zhongguo Yaofang in 2014.HPLC of Formula: 126-14-7 This article mentions the following:
The aim is to establish a method for the content determination of pharmaceutical adjuvant of sucrose octaacetate. HPLC method was adopted. The determination was performed on MG II C18 column with mobile phase of acetonitrile-water(75:25, V/V)at the flow rate of 1.0 mL/min. The column temperature was 30 °C, and the detection wavelength was set at 210 nm. The sample size was 20 μl. The contents of 3 batches of samples were determined, and compared with the method stated in the USP. The linear range of sucrose octaacetate was 1.0-10 mg/mL(r=0.999 9) with an average recovery of 100.8%(RSD=0.5%, n=3). The content of sucrose octaacetate determined by the method of USP was 1% higher than this method; this value might contain the weight of impurity. The method was simple, specific and reproducible, and could control the quality of sucrose octaacetate effectively. The accuracy of it was better than that of USP. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3S,4R,5R)-3,4-diacetoxy-2,5-bis(acetoxymethyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (cas: 126-14-7HPLC of Formula: 126-14-7).
(2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3S,4R,5R)-3,4-diacetoxy-2,5-bis(acetoxymethyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (cas: 126-14-7) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.HPLC of Formula: 126-14-7
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem