Month: November 2022

Method for reducing primer dimer formation and increasing amplification efficiency was written by Lee, Young Jo; Kim, Dae Young. And the patent was published on July 5,2018.Reference of 550-33-4 The following contents are mentioned in the patent:

The present invention relates to a method for amplifying at least three target nucleic acid mols. with reduced primer dimer formation in a multiplex amplification reaction. The method of present invention can inhibit primer dimer formation and hence generation of nonspecific amplification products in an effective manner in a multiplex amplification reaction for at least three target nucleic acid mols. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Reference of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Reference of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Preparation of 2-deoxy-2-fluoro-glycoside-bound nucleotides as glycosyltransferase inhibitors was written by Wong, Chi-huey; Hayashi, Takashi. And the patent was published on June 18,1998.HPLC of Formula: 67341-43-9 The following contents are mentioned in the patent:

Nucleotide linked 2-deoxy-2-fluoroglycosides are employed as potent competitive inhibitors of glycosyltransferases. More particularly, uridine-5′-diphospho-2-deoxy-2-fluoro-galactose (UDP-2F-Gal), guanidine-5′-diphospho-2-deoxy-2-fluoro-L-fucose (GDP-2F-Fuc), uridine-5′-diphospho-2-deoxy-2-fluoro-D-glucose (UDP-2F-Glu), guanosine-5′-diphospho-2-deoxy-2-fluoro-D-mannose (GDP-2F-Man), cytosine-5′-monophospho-2-deoxy-2-fluoro-D-sialic acid, and cytosine-5′-monophospho-2-deoxy-2-KDO may be employed as inhibitors of β-1,4-galactosyltransferase, α-1,3-fucosyltransferase, glucosyltransferases, N-acetylglucosaminyltransferases, α-mannosyltransferases, α-sialyltransferases, and KDO-transferases, resp. Synthesis of nucleotide-linked-2-deoxy-2-fluoroglycosides is achieved using either chemoenzymic or chem. methodologies. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9HPLC of Formula: 67341-43-9).

Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.HPLC of Formula: 67341-43-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Preparation of cyclic dinucleotides as STING agonists was written by Beigelman, Leonid; Bignan, Gilles; Connolly, Peter J.; Edwards, James Patrick; Emanuel, Stuart; Laquerre, Sylvia; Richter, Mark; Schepens, Wim Gert Griet; Thatikonda, Santhosh Kumar; Thuring, Johannes Wilhelmus John Fitzgerald; Viellevoye, Marcel; Wang, Guangyi; Zhong, Minghong. And the patent was published on June 20,2019.Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol The following contents are mentioned in the patent:

Cyclic dinucleotides I, wherein B1 and B2 are independently nucleobase; R1a is H, OH, F, alkoxy; R1b is H, F, OH; provided that when R1b is F, R1a is H or F; R1c is H or Me; R2a is H,, OH, F, alkoxy; R2b is H, F, or OH; provided that when R2b is F, R2a is H or F; R2c is H, F, CH3, or CH2F; X1 and X2 are the group consisting of O, S, and CH2; Y and Y1 are each independently absent or O or NH; Z and Z1 are the group consisting of O and NH; M and M1 are independently SO2, substituted phosphate, substituted thiophosphate, were prepared and used for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Thus, cyclic dinucleotide II was prepared and used as antitumor and antiviral agent and vaccine. Cyclic dinucleotides are used for treating of diseases, syndrome, melanoma, colon cancer, breast cancer, prostate cancer, lung cancer, and fibrosarcoma, hepatitis B. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Non-DNA base-containing polynucleotide compositions and their use for the modulation of immune responses was written by Phillips, Nigel C.; Filion, Mario C.. And the patent was published on May 12,2011.Synthetic Route of C10H12N4O4   The following contents are mentioned in the patent:

The present invention provides compositions comprising synthetic non-DNA base-containing polynucleotide sequences of 3 to 30 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases, in combination with a pharmaceutically acceptable vehicle, particularly one or more adjuvant vehicle, and one or more antigen. The present invention relates to methods of administering these compositions for inducing or modulating an immune response in vitro or in vivo, and particularly for activating antigen presenting cells. The present invention relates to compositions comprising synthetic non-DNA base-containing polynucleotides, a pharmaceutically acceptable vehicle and optionally one or more antigens, and their use to modulate immune responses. Several of the compositions of the present invention permit lower doses of antigen to be used in a vaccine formulation. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Synthetic Route of C10H12N4O4  ).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Synthetic Route of C10H12N4O4  

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bioherbicides for controlling one or more plant species was written by Frank, Joseph; Shakeel, Ameer Hamza; Carballo, Sergio Madrigal; Zomorodi, Sepehr; Pourtaheri, Payam. And the patent was published on May 27,2022.Recommanded Product: 550-33-4 The following contents are mentioned in the patent:

The present disclosure provides compositions and methods for suppressing growth of various plant species with bioactive agents. Also, the present disclosure provides agricultural compositions and methods of using the formulations containing minicells and bioactive agents for targeted delivery and controlled release to enhance control of various plant species in a stable and scalable manner. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Recommanded Product: 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Recommanded Product: 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lin28/let-7 crystal structures, purification protocols, and modified tumor suppressor hairpin oligonucleotides, suitable for use in Lin28 inhibitor screening assays and cancer therapy was written by Sliz, Piotr; Nam, Yunsun. And the patent was published on May 16,2013.Related Products of 550-33-4 The following contents are mentioned in the patent:

The invention provides oligonucleotides, compositions and methods for regulating let-7 microRNA biogenesis by inhibiting Lin28. The invention also relates to compositions and methods for screening inhibitors of Lin28 activity that increase the level of mature let-7 miRNA in a cell. The invention also relates to a method of treating or preventing cancer in a subject, using oligonucleotides to promote cellular processing of tumor suppressor miRNA in combination with other therapies. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Related Products of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Related Products of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

TET proteins for selective oxidation of 5-methylcytosine and generation of human Foxp3+ T cells and TET protein inhibitors for production of induced pluripotent stem cells to treat degenerative diseases was written by Rao, Anjana; Tahiliani, Mamta; Koh, Kian Peng; Agarwal, Suneet; Iyer, Aravind. And the patent was published on April 1,2010.Category: tetrahydrofurans The following contents are mentioned in the patent:

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9Category: tetrahydrofurans).

Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Copper cleaning and protection formulations was written by Barnes, Jeffrey A.; Benac, Brian; Boggs, Karl E.; Feng, Lin; Liu, Jun; Petruska, Melissa A.; Yan, Xiaodong; Zhang, Peng. And the patent was published on April 29,2010.Product Details of 550-33-4 The following contents are mentioned in the patent:

Disclosed is a cleaning composition and process for cleaning post-chem. mech. polishing (CMP) residue and contaminants from a microelectronic device having said residue and contaminants thereon. The cleaning compositions include novel corrosion inhibitors. The composition achieves highly efficacious cleaning of the post-CMP residue and contaminant material from the surface of the microelectronic device without compromising the low-k dielec. material or the copper interconnect material. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Product Details of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Product Details of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Content dependent inhibitors of cytidine deaminases and uses thereof was written by Wedekind, Joseph E.; Smith, Harold C.. And the patent was published on April 17,2012.Safety of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol The following contents are mentioned in the patent:

This invention relates to cytidine deaminase inhibitors (Cytidine deaminase inhibitors) of cytidine deaminases and uses thereof. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Safety of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Safety of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem