Month: November 2022

Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19 was written by Fier, Patrick S.;Xu, Yingju;Poirier, Marc;Brito, Gilmar;Zheng, Michelle;Bade, Rachel;Sirota, Eric;Stone, Kevin;Tan, Lushi;Humphrey, Guy R.;Chang, Darryl;Bothe, Jameson;Zhang, Yongqian;Bernardoni, Frank;Castro, Steve;Zompa, Michael A.;Taylor, Jerry;Sirk, Kevin M.;Diaz-Santana, Anthony;Diribe, Ike;Emerson, Khateeta M.;Krishnamurthi, Bharath;Zhao, Ralph;Ward, Michael;Xiao, Chengqian;Ouyand, Honggui;Zhan, Jianfeng;Morris, William J.. And the article was included in Organic Process Research & Development in 2021.Category: tetrahydrofurans The following contents are mentioned in the article:

Herein is described the development of a large-scale manufacturing process for molnupiravir, an orally dosed antiviral that was recently demonstrated to be efficacious for the treatment of patients with COVID-19. The yield, robustness, and efficiency of each of the five steps were improved, ultimately culminating in a 1.6-fold improvement in overall yield and a dramatic increase in the overall throughput compared to the baseline process. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5Category: tetrahydrofurans).

((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

A novel model of molnupiravir against SARS-CoV-2 replication: accumulated RNA mutations to induce error catastrophe was written by Zhao, Yuxi;He, Gu;Huang, Wei. And the article was included in Signal Transduction and Targeted Therapy in 2021.Application of 2492423-29-5 The following contents are mentioned in the article:

A review. This article discusses about findings of a recent systematic biochem. anal. that proposed a two-step mechanism for molnupiravir-induced mutagenesis of coronavirus RNA. The experiments suggest a two-step mechanism in which molnupiravir induces SARS-CoV-2 RNA mutagenesis by forming stable M-G and M-A base pairs in the RdRp active site. Therefore, future studies should assess the potential long-term genotoxic side effects of molnupiravir. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5Application of 2492423-29-5).

((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Application of 2492423-29-5

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Computer aided comparison of the new oral drug Molnupiravir and independently designed and previously reported drug like molecule (HAD-08) was written by Mullasseril, Abhilash. And the article was included in World Journal of Pharmaceutical Research in 2022.Formula: C13H19N3O7 The following contents are mentioned in the article:

The medicinal scientists and drug researchers around the world are facing various complicated challenges always but particularly in this pandemic period. They are constantly trying to overcome the hurdles of the puzzles given by the COVID-19. In this research work a computer aided comparison of the newly introduced oral drug Molnupiravir and an independently designed and previously reported drug like mol. (HAD-08) are compared without any prejudices. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5Formula: C13H19N3O7).

((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Formula: C13H19N3O7

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Pfizer to license COVID-19 antiviral was written by Michael McCoy. And the article was included in Chemical & Engineering News in 2021.Related Products of 2492423-29-5 The following contents are mentioned in the article:

A review. This article discusses about Pfizer to license COVID-19 antiviral. Pfizer will license its COVID-19 antiviral, PF-07321332, to the Medicines Patent Pool (MPP), which will make the drug available to generic-drug makers in low- and middle-income countries, assuming it is approved. Merck & Co. struck a similar deal with MPP in Oct. for its investigational antiviral, molnupiravir. Pfizer says lower-income countries will pay a not-forprofit price. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5Related Products of 2492423-29-5).

((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Related Products of 2492423-29-5

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells was written by Imamura, Kenta;Asai, Momoko;Sugamoto, Kazuhiro;Matsumoto, Tomoko;Yamasaki, Yumi;Kamei, Ichiro;Hattori, Takahiro;Kishimoto, Masaoki;Niisaka, Seiji;Kubo, Masaomi;Nishiyama, Kazuo;Yamasaki, Masao. And the article was included in Bioscience, Biotechnology, and Biochemistry in 2015.HPLC of Formula: 24386-93-4 The following contents are mentioned in the article:

In this study, we focused on the anti-inflammatory effect of cordycepin, 3′-deoxyadenosine. Cordycepin potently suppressed nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells in an adenosine receptor-independent manner. In addition, inhibitors for adenosine kinase and nucleoside transporter abrogated the action of cordycepin. Thus, we considered that intracellular metabolism cordycepin is important for the anti-inflammatory effect of cordycepin. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4HPLC of Formula: 24386-93-4).

(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.HPLC of Formula: 24386-93-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

DYRK1A: a promising drug target for islet transplant-based diabetes therapies was written by Belgardt, Bengt-Frederik;Lammert, Eckhard. And the article was included in Diabetes in 2016.Formula: C11H13IN4O4 The following contents are mentioned in the article:

A review. This article discussed about dual-specificity tyrosine phosphorylation-regulated kinase as a promising drug target for islet transplant-based diabetes therapies and several other small mols. to induce human β-cell proliferation such as adenosine kinase inhibitor, 5-iodotubercidin which stimulates human β-cell proliferation in vitro, as well as upon transplantation of human islets into mice in vivo and long-term treatment of islets with 5-IT improved glucose-stimulated insulin secretion in type 2 diabetes patients. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4Formula: C11H13IN4O4).

(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Formula: C11H13IN4O4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Short synthesis of molnupiravir (EIDD-2801) via a thionated uridine intermediate was written by Dey, Raghunath;Nayak, Sourav;Das, Parthasarathi;Yadav, Somnath. And the article was included in ACS Omega in 2021.HPLC of Formula: 2492423-29-5 The following contents are mentioned in the article:

Molnupiravir (MK-4482, EIDD-2801) is an exptl. drug that has been demonstrated to be effective for the treatment of COVID-19 in human clin. trials. Herein, we report a concise synthesis of the drug via a novel thionated derivative that relies on one-pot methodologies, thus decreasing the number of purification steps required. This route provides the drug in an overall 62% yield and >99% purity and uses cheap and readily available bulk chems., thereby providing an affordable synthesis of the drug for cheaper and wider global accessibility. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5HPLC of Formula: 2492423-29-5).

((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.HPLC of Formula: 2492423-29-5

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Design and synthesis of fluorescent 7-deazaadenosine nucleosides containing π-extended diarylacetylene motifs was written by De Ornellas, Sara;Slattery, John M.;Edkins, Robert M.;Beeby, Andrew;Baumann, Christoph G.;Fairlamb, Ian J. S.. And the article was included in Organic & Biomolecular Chemistry in 2015.Safety of (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol The following contents are mentioned in the article:

C-modified 7-deazaadenosines containing a diphenylacetylene moiety have been synthesized using cross-coupling approaches. The C-modified nucleosides exhibit remarkable fluorescence properties, including high quantum yields. Solvatochromic studies show a near linear correlation between the Stokes shift and solvent polarity which is indicative of intramol. charge transfer. DFT calculations have allowed us to correlate the exptl. observed photo-phys. properties with the calculated HOMO-LUMO energy gaps within a series of real and model compounds This study involved multiple reactions and reactants, such as (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4Safety of (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol).

(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Safety of (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

What impact can molnupiravir have on the treatment of SARS-CoV-2 infection? was written by Kayali, Fatima;Leung, Marco Shiu Tsun;Wong, Wilson;Morgan, Kara Pittendrigh;Harky, Amer. And the article was included in Expert Opinion on Pharmacotherapy in 2022.Formula: C13H19N3O7 The following contents are mentioned in the article:

A review. This review will highlight molnupiravir’s impact on the treatment of COVID-19, through analyzing latest clin. trial data and possible limitations of this drug. This novel drug inhibits the RNA-dependent RNA polymerase (RdRp) enzyme which subsequently results in RNA virus replication errors. Molnupiravir has been shown to potentially halving all hospitalization and deaths in mild to moderate COVID-19 cases. As an oral antiviral that can be taken at home, molnupiravir provides a promising advancement in our fight against COVID-19, alongside vaccination. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5Formula: C13H19N3O7).

((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Formula: C13H19N3O7

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Study on the Synthesis and PKA-I Binding Activities of 5-Alkynyl Tubercidin Analogues was written by Zhang, Liangren;Zhang, Yunlong;Li, Xianghui;Zhang, Lihe. And the article was included in Bioorganic & Medicinal Chemistry in 2002.Application of 24386-93-4 The following contents are mentioned in the article:

5-Alkynyl tubercidin analogs were synthesized and their biol. activities were evaluated. It was found that protein kinase A could be activated by 5-alkynyl tubercidin (I) and cAMP-binding ability to PKA-I was selectively inhibited by it. Mol. modeling showed that the interaction of I and PKA-I was associated with the existence of hydrophobic alkynyl group. During the synthesis of tubercidin analogs, a pair of 2′-carbonyl participating abnormal coupling products was obtained, the structure was identified by X-ray crystalline diffraction. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4Application of 24386-93-4).

(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Application of 24386-93-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem