A mini-review on clinical studies of Molnupiravir for COVID-19 conducted in selected Asian countries was written by Querequincia, Joseph Mari B.;Faller, Erwin M.. And the article was included in GSC Biological and Pharmaceutical Sciences in 2022.Synthetic Route of C13H19N3O7 The following contents are mentioned in the article:
A review. The key goal of this mini review article is to provide enough data and info on the several clin. trials conducted in some number of countries in the Asia on the use of the drug Molnupiravir for Coronavirus disease 2019 (COVID-19). It is caused by severe acute respiratory syndrome coronavirus 2 has extended across the globe in the previous years. Vaccines and antiviral agents were being tested for their efficacies in order to prevent the occurrence of the disease. An antiviral agent, Molnupiravir which is ribonucleoside analog which is a prodrug that can be converted to its active form intracellularly. There were countries like USA and United Kingdom conducted the preliminary clin. trials for the efficacy of this drug. In the Asian region, countries like Japan, Israel, Philippines, Russia, South Korea and Taiwan participated in the clin. studies for Molnupiravir which is under Phase 3 clin. trial. Doses from 200 – 800 mg/kg were utilized in the studies. These certain doses are well tolerated and there were no severe adverse effects that were noted. Thus, Molnupiravir is a potential antiviral agent that can be utilized to treat and prevent COVID-19 infections and endeavored to be fully established. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5Synthetic Route of C13H19N3O7).
((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Synthetic Route of C13H19N3O7
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem