Fier, Patrick S. et al. published their research in Organic Process Research & Development in 2021 | CAS: 2492423-29-5

((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Category: tetrahydrofurans

Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19 was written by Fier, Patrick S.;Xu, Yingju;Poirier, Marc;Brito, Gilmar;Zheng, Michelle;Bade, Rachel;Sirota, Eric;Stone, Kevin;Tan, Lushi;Humphrey, Guy R.;Chang, Darryl;Bothe, Jameson;Zhang, Yongqian;Bernardoni, Frank;Castro, Steve;Zompa, Michael A.;Taylor, Jerry;Sirk, Kevin M.;Diaz-Santana, Anthony;Diribe, Ike;Emerson, Khateeta M.;Krishnamurthi, Bharath;Zhao, Ralph;Ward, Michael;Xiao, Chengqian;Ouyand, Honggui;Zhan, Jianfeng;Morris, William J.. And the article was included in Organic Process Research & Development in 2021.Category: tetrahydrofurans The following contents are mentioned in the article:

Herein is described the development of a large-scale manufacturing process for molnupiravir, an orally dosed antiviral that was recently demonstrated to be efficacious for the treatment of patients with COVID-19. The yield, robustness, and efficiency of each of the five steps were improved, ultimately culminating in a 1.6-fold improvement in overall yield and a dramatic increase in the overall throughput compared to the baseline process. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5Category: tetrahydrofurans).

((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem