Merck to seek EUA for molnupiravir was written by Bethany Halford;Laura Howes;Megha Satyanarayana. And the article was included in Chemical & Engineering News in 2021.Synthetic Route of C13H19N3O7 The following contents are mentioned in the article:
The oral antiviral molnupiravir cuts the risk of hospitalization and death from COVID-19 by 50% in people with mild to moderate disease. Merck & Co. and Ridgeback Biotherapeutics reported the data , which come from interim anal. of their Phase 3 trial, in a press release. The data have not been peer-reviewed. Based on the pos. results, Merck plans to submit an application for emergency use authorization (EUA) to the US Food and Drug Administration as soon as possible and seek similar approval from other regulatory agencies worldwide. The companies report that 28 of 385 patients-about 7%-who received molnupiravir were hospitalized with COVID-19. None of the patients died. Of the 377 patients who received a placebo, 53-14%-were hospitalized, and 8 died. In addition to a pos. diagnosis of COVID-19, all the patients in the trial had at least one risk factor associated with poor disease outcomes, such as obesity or being 60 or older. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5Synthetic Route of C13H19N3O7).
((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Synthetic Route of C13H19N3O7
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem