Sakatsume, Osamu published the artcileSolid phase synthesis of oligoribonucleotides by the phosphoramidite approach using 2′-O-1-(2-chloroethoxy)ethyl protection, Synthetic Route of 87865-78-9, the publication is Tetrahedron (1991), 47(41), 8717-28, database is CAplus.
The new protecting group, 1-(2-chloroethoxy)ethyl (Cee), has been employed for the protection of the 2′-OH groups of ribonucleoside residues in the synthesis of oligoribonucleotides by the phosphoramidite approach on a solid support, using the acid-labile 5′-O-dimethoxytrityl (DMTr) group. The Cee group is completely stable under the acidic conditions required to remove the 5′-terminal protecting groups in oligonucleotide synthesis on a solid support, and yet is easily removable under mild condition of acidic hydrolysis (pH 2.0) for the final unblocking step. The Cee-protected ribonucleoside 3′-phosphoramidite units were evaluated in the synthesis of homopolymers of cytidine, the box 9R and 9R’ sequences of Tetrahymena rRNA, and a leader sequence of phage Qβ-A protein mRNA. Procedures for the deprotection and purification of the synthetic oligoribonucleotides are also described.
Tetrahedron published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Synthetic Route of 87865-78-9.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem