Day: November 21, 2022

Binh, Nguyen Tan published the artcileBioactive compounds from marine fungus penicillium citrinum strain ND7c by gas chromatography-mass spectrometry, Quality Control of 19444-84-9, the publication is Pharmaceutical and Chemical Journal (2018), 5(1), 211-224, database is CAplus.

The objectives of this study were anal. of the secondary metabolite products from extract of marine Penicillium citrinum strain ND7a which isolated from sponges at Ha Tien Sea, Kien Giang province, Vietnam. Sixteen bioactive compounds were identified in the organic solvent hexan-aceton and aceton-methanol. The identification of bioactive chem. compounds is based on the peak area, retention time, mol. weight and mol. formular. GC-MS anal. of Penicillium citrinum strain ND7a revealed the existence of the 9-Hexadecenoic acid, Hexadecane, n-Hexadecanoic acid, Heptacosane, Octadecane, 3-ethyl-5-(2-ethylbutyl), Tri-Bu acetylcitrate, 17-Pentatriacontene, Hexanedioic acid, bis(2-ethylhexyl) ester, Bis(2-ethylhexyl) phthalate (in organic solvent hexan-aceton) and Oxime-, methoxy-Ph, 2-Hydroxy-gamma-butyrolactone, 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, Pentadecanoic acid, 14-methyl-, Me ester, Hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester, Stigmasterol, γ-Sitosterol (in organic solvent aceton-methanol).

Pharmaceutical and Chemical Journal published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Yuehui published the artcileLewis Acid Promoted Ruthenium(II)-Catalyzed Etherifications by Selective Hydrogenation of Carboxylic Acids/Esters, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Angewandte Chemie, International Edition (2015), 54(17), 5196-5200, database is CAplus and MEDLINE.

Ethers are of fundamental importance in organic chem. and they are an integral part of valuable flavors, fragrances, and numerous bioactive compounds In general, the reduction of esters constitutes the most straightforward preparation of ethers. Unfortunately, this transformation requires large amounts of metal hydrides. Presented herein is a bifunctional catalyst system, consisting of Ru/phosphine complex and aluminum triflate, which allows selective synthesis of ethers by hydrogenation of esters or carboxylic acids. Different lactones were reduced in good yields to the desired products. Even challenging aromatic and aliphatic esters were reduced to the desired products. Notably, the in situ formed catalyst can be reused several times without any significant loss of activity.

Angewandte Chemie, International Edition published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Dellinger, Douglas J. published the artcileStreamlined Process for the Chemical Synthesis of RNA Using 2′-O-Thionocarbamate-Protected Nucleoside Phosphoramidites in the Solid Phase, Product Details of C26H45N5O7Si2, the publication is Journal of the American Chemical Society (2011), 133(30), 11540-11556, database is CAplus and MEDLINE.

An improved method for the chem. synthesis of RNA was developed utilizing a streamlined method for the preparation of phosphoramidite monomers and a single-step deprotection of the resulting oligoribonucleotide product using 1,2-diamines under anhydrous conditions. The process is compatible with most standard hetero-base protection and employs a 2′-O-(1,1-dioxo-1λ⁶-thio-morpholine-4-carbo-thioate) as a unique 2′-hydroxyl protective group. Using this approach, it was demonstrated that the chem. synthesis of RNA can be as simple and robust as the chem. synthesis of DNA.

Journal of the American Chemical Society published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Product Details of C26H45N5O7Si2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Karuppiah, Vijayakumar published the artcileAnti-quorum sensing and antibiofilm potential of 1,8-cineole derived from Musa paradisiaca against Pseudomonas aeruginosa strain PAO1, Name: 3-Hydroxydihydrofuran-2(3H)-one, the publication is World Journal of Microbiology & Biotechnology (2021), 37(4), 66, database is CAplus and MEDLINE.

Abstract: Pseudomonas aeruginosa is one of the vulnerable opportunistic pathogens associated with nosocomial infections, cystic fibrosis, burn wounds and surgical site infections. Several studies have reported that quorum sensing (QS) systems are controlled the P. aeruginosa pathogenicity. Hence, the targeting of QS considered as an alternative approach to control P. aeruginosa infections. This study aimed to evaluate the anti-quorum sensing and antibiofilm inhibitory potential of Musa paradisiaca against Chromobacterium violaceum (ATCC 12472) and Pseudomonas aeruginosa. The methanol extract of M. paradisiacsa exhibits that better antibiofilm potential against P. aeruginosa. Then, the crude methanol extract was subjected to purify by column chromatog. and collected the fractions. The mass-spectrometric anal. of a methanol extract of M. paradisiaca revealed that 1,8-cineole is the major compounds 1, 8-cineole significantly inhibited the QS regulated violacein production in C. violaceum. Moreover, 1,8-cineole significantly inhibited the QS mediated virulence production and biofilm formation of P. aeruginosa without affecting their growth. The real-time PCR anal. showed the downregulation of autoinducer synthase and transcriptional regulator genes upon 1,8-cineole treatment. The findings of the present study strongly suggested that metabolite of M. paradisiaca impedes P. aeruginosa QS system and associated virulence productions.

World Journal of Microbiology & Biotechnology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Name: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Malathi, H. published the artcileThin layer chromatography and GC-MS analysis of bioactive molecules of the Acacia ferruginea DC. thorn extract, Related Products of tetrahydrofurans, the publication is Asian Journal of Biological and Life Sciences (2021), 10(1), 110-117, database is CAplus.

The aim of the current study is to investigate thethin layer chromatog. (TLC) and gas chromatog. and mass spectroscopy anal. (GC-MS) of methanolic extract of Acacia ferruginea thorns. The bioactive mols. were determined by qual. TLC and GC-MS method. In TLC exhibited maximum 0.6 retention factor (RF) value of the plant extract in F254 wavelength in dark blue color, F366 wave length and in visible light not shown any peaks and RF values. In the GC-MS anal., 37 bioactive mols. were exhibited and in that 10 are in higher concentration by the retention time and their % of peak and area covered in the anal. compared to other chromatograms of the fractions. Important compounds identified as Me mannose (57.14), Phenol, 2-methoxy-3-(2-propenyl)- (4.85), stigmasterol (4.65), 1-Hexacosanol (3.83), Lupeol (3.60), gamma Sitosterol (3.52), Phenol, 4-[2-(dimethylamino)ethyl]-(3.17), Ergost-5-en- 3-ol, (3.beta.)- (2.53), Oleic acid (2.44), Oleoyl chloride (1.53), Sucrose (1.82). The presence of these bioactive mols. in the plant extract may provide the scientific evidences for the cytotoxic effect, insecticidal and other biol. properties.

Asian Journal of Biological and Life Sciences published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Peng, Yuhan published the artcileAnalysis of pyrolysis behaviors of biomass extractives via non-linear stepwise heating program based on Gaussian multi-peak fitting of differential thermogravimetric curve, Quality Control of 19444-84-9, the publication is Thermochimica Acta (2021), 178976, database is CAplus.

The thermal decomposition of extractives can yield addnl. products, resulting in a different final product distribution of bio-oil, especially for extractives-rich biomass. However, the thermal decomposition behavior of extractives themselves has long been ignored, but deserves deep investigation. Herein, the non-linear stepwise heating program based on Gaussian multi-peak fitting of differential thermogravimetric curve for biomass extractives was designed. Using this stepwise heating program, the pyrolysis process of different chem. substances in biomass extractives was effectively decoupled and systematically studied. As for water-soluble extractives, the evaporation of volatile substances, the thermal decomposition of water-soluble carbohydrates, phenolic substances, and nitrogenous substances proceed in sequence with the increase of temperature during the pyrolysis process. With regard to liposol. extractives, the pyrolysis included the volatilization of endogenous substances and the thermal decomposition of different lipids into olefins. This work provides a systematic understanding of thermal decomposition process in the extractives of lignocellulosic biomass.

Thermochimica Acta published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Jensen, Pernille Rose published the artcileProbing the Lewis Acid Catalyzed Acyclic Pathway of Carbohydrate Conversion in Methanol by In Situ NMR, Application of 3-Hydroxydihydrofuran-2(3H)-one, the publication is ChemCatChem (2019), 11(20), 5077-5084, database is CAplus.

Future bioindustries will rely on the formation of diverse chems. at high yield through various reaction pathways. These pathways include reactions to a series of alpha-hydroxy esters and acids that can be formed from the conversion of C3-C6 carbohydrates by Lewis acidic catalysts in alcs. and water. Definitive kinetic and mechanistic insights to support the development of carbohydrate conversion processes are arguably less developed than for analogous biocatalytic processes. Here, we visualize acyclic pathways of carbohydrate dehydration, using the acyclic C4 carbohydrate erythrulose as a probe mol. for the conversion by homogeneous SnCl₄ in methanol. In situ studies allow the detection of previously postulated intermediates, identify the branch point to competing products and provide energetic and mechanistic insight by kinetic anal. Reversibility of reactions, stereoselectivity and differential propensity for deuterium incorporation in competing pathways can be tracked by the formation of compounds with asym. mass distribution.

ChemCatChem published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Application of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Fathalinejad, Samin published the artcileChemical composition analysis of carbohydrate fragmentation products, Formula: C4H6O3, the publication is Journal of Analytical and Applied Pyrolysis (2021), 105112, database is CAplus.

Fragmentation of simple sugars, using fluidized thermal bed cracking, results in a mixture that contains a variety of polar oxygenated compounds, some yet unknown to the industries. This lack of understanding of the product composition, hinders the downstream processes in conversion of sugars to useful chems. The aim of this study was fourfold: to develop a GC-MS identification workflow for carbohydrate fragmentation compounds, to build a library of compounds detected by five GC-MS methods including liquid injection, liquid-liquid extraction, static headspace, solid-phase microextraction and derivatization, to investigate and compare the compound coverage of the five methods, and finally investigate possible reaction pathways for some of the analytes in the mixture The anal. was done on a mixture of seven representative sugar fragmentation samples. The identification workflow was based on mass spectral match factors (>80%), retention indexes and anal. standards A total of 389 compounds were detected, out of which, 46 compounds were fully identified (through confirmatory anal. of anal. standards), 87 were tentatively identified (spectral match factors above 80%), 71 were un-identified with spectral match factors of below 80% and 185 were discarded (contaminants in blanks, etc.). The production pathway for some of the identified compounds in the sugar conversion mixtures were also discussed. In conclusion, solid-phase microextraction detected the highest number of analytes (93), mostly volatile organic compounds and the derivatization GC-MS technique detected the lowest number of analytes (19) but was the only method to detect the largest mols. (C₆-C₁₂) in size. This library of CF products can be used as a suspect-screening database for other biomass fragmentation mixtures

Journal of Analytical and Applied Pyrolysis published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ramakrishna, Ubbani published the artcileDesign and synthesis of novel hydroxy-anthraquinone derivatives as anti-leishmanial agents, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is World Journal of Pharmaceutical Research (2017), 6(16), 759-764, database is CAplus.

A novel series of hydroxy-anthraquinone derivatives I [R = 1,2-di-OH, 2,3-di-OH, 1-Me-2,3-di-OH, etc.; R¹ = 5-OH, 8-OH] was synthesized via Friedel-Crafts acylation reaction of phenols and hydroxyphthalic anhydride and identified as potential antileishmanial chemotype. Among the synthesized analogs I [R = 5-OH, R¹ = 3,5-di-OH; R = 8-OH, R¹ = 1,4-di-OH] exhibited better antileishmanial activity against intracellular amastigotes form of Leishmania donovani. The compounds I were also non-toxic toward Vero cells. Compounds I [R = 5-OH, 8-OH; R¹ = 1,2-di-OH, 1,2,3-tri-OH] also showed significant in vitro activity against intracellular amastigotes form of Leishmania donovani.

World Journal of Pharmaceutical Research published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Zijian published the artcileElectrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides, Application In Synthesis of 19444-84-9, the publication is Journal of the American Chemical Society (2021), 143(9), 3536-3543, database is CAplus and MEDLINE.

As alcs. are ubiquitous throughout chem. science, this functional group represents a highly attractive starting material for forging new C-C bonds. Here, it is demonstrated that the combination of anodic preparation of alkoxy triphenylphosphonium ion and nickel catalyzed cathodic reductive cross-coupling provides an efficient method to construct C(sp²)-C(sp³) bonds, in which free alcs. and aryl bromides e.g., bromobenzene-both readily available chems. can be directly used as coupling partners yielding arene derivative e.g., I. This nickel catalyzed paired electrolysis reaction features a broad substrate scope bearing a wide gamut of functionalities, which was illustrated by the late-stage arylation of several structurally complex natural products and pharmaceuticals.

Journal of the American Chemical Society published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Application In Synthesis of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem