Lackey, Jeremy G. published the artcileToward the discovery of new antifungal agents: the design and validation of a novel 2’P-RNA probe and high throughput screening assay against 2′-phosphotransferase Tpt1p, Category: tetrahydrofurans, the publication is Nucleic Acids Symposium Series (2008), 52(1), 475-476, database is CAplus and MEDLINE.
We report the solid-phase synthesis of novel 2’P-RNA probes for use in fluorescence polarization (FP) ligand binding assays that screens for inhibitors of the yeast 2′-phosphotransferase Tpt1p. The probe was synthesized by utilizing silyl phosphoramidite chem. and a phosphoramidite synthon containing an orthogonal (DMT) protecting group at its 2′-position. Regioselective removal of the 2′-DMT group and phosphitylation of the unmasked 2′-hydroxyl group afforded the desired 2’P-RNA sequence.
Nucleic Acids Symposium Series published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Category: tetrahydrofurans.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem