Chen, Zhuo published the artcileAcenaphtho[1,2-b]pyrrole-Based Selective Fibroblast Growth Factor Receptors 1 (FGFR1) Inhibitors: Design, Synthesis, and Biological Activity, Application of 2-Methyl-3-tetrahydrofuranthiol, the publication is Journal of Medicinal Chemistry (2011), 54(11), 3732-3745, database is CAplus and MEDLINE.
A novel series of acenaphtho[1,2-b]pyrrole derivatives as potent and selective inhibitors of fibroblast growth factor receptor 1 (FGFR1) were designed and synthesized. In silico target prediction revealed that tyrosine kinases might be the potential targets of the representative compound I, which was subsequently validated by ELISA for its selective and active FGFR1 inhibition of various tyrosine kinases. The structure-activity relationship (SAR) anal. aided by mol. docking simulation in the ATP-binding site demonstrated that acenaphtho[1,2-b]pyrrolecarboxylic acid esters are potent inhibitors of FGFR1 with IC50 values ranging from 19 to 77 nM. Furthermore, these compounds exhibited favorable growth inhibition property against FGFR-expressing cancer cell lines with IC50 values ranging from micromolar to submicromolar. Western blotting anal. showed that three of these compounds inhibited activation of FGFR1 and extracellular-signal regulated kinase 1/2 (Erk1/2).
Journal of Medicinal Chemistry published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, Application of 2-Methyl-3-tetrahydrofuranthiol.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem