Biocatalytic synthesis of seleno-, thio- and chloro-nucleobase modified nucleosides by thermostable nucleoside phosphorylases was written by Zhou, Xinrui; Yan, Weizhu; Zhang, Chong; Yang, Zhaoyi; Neubauer, Peter; Mikhailopulo, Igor A.; Huang, Zhen. And the article was included in Catalysis Communications on March 5,2019.Formula: C10H12N4O4 The following contents are mentioned in the article:
Selenium-containing nucleosides are the building blocks of the Se-nucleic acids useful for structure-and-function study, drug discovery and for targeting nucleic acids and their protein complexes. However, chem. synthesis of these Se-containing nucleosides is labor-intensive and provides low overall yields. Thus, we decided to explore biocatalytic synthesis of the modified nucleosides (such as Se-nucleosides) by employing thermostable nucleoside phosphorylases from thermophilic microorganisms. We were surprised to discover that these enzymes can still recognize the nucleobases containing rather larger atoms, Se vs. O atom. These enzymes also showed excellent adaptability to some modified purines with high substrate conversion (up to 97%). This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Formula: C10H12N4O4 ).
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Formula: C10H12N4O4
550-33-4;(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol;The future of 550-33-4;New trend of C10H12N4O4 ;function of 550-33-4