Synergistic effect of 3′-deoxyadenosine N1-oxide and adenosine deaminase inhibitors on growth of Ehrlich ascites tumor cells in vivo was written by Svendsen, Karsten Ramloev; Overgaard-Hansen, Kay; Frederiksen, Sune. And the article was included in Cancer Chemotherapy and Pharmacology on February 29,1988.Product Details of 13146-72-0 The following contents are mentioned in the article:
The simultaneous administration of 3′-deoxyadenosine N’-oxide (3′-dANO) and the adenosine deaminase inhibitors erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) or 2′-deoxycoformycin (2′-dCF) to mice bearing Ehrlich ascites tumor cells resistant to 3′-dANO resulted in 80%-90% inhibition of tumor growth in vivo. 3′-DANO and 2′-dCF increased the survival time of tumor-bearing mice by a factor of 2. In vitro studies showed that the 3′-dANO resistant Ehrlich cells initiate the metabolism of 3′-dANO by a reduction to 3′-deoxyadenosine, which is converted primarily to 3′-deoxyinosine by adenosine deaminase and, to a small extent, phosphorylated to the cell toxic agent 3′-dATP. By the addition of EHNA or 2′-dCF, it was possible to block the formation of 3′-deoxyinosine; this stimulated the accumulation of 3′-dATP. Resistance to 3′-dANO in cell cultures was accompanied by changes in the following enzyme activities: reductase, adenosine kinase, and the adenosine deaminase. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Product Details of 13146-72-0).
9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Product Details of 13146-72-0
13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0