Human erythrocytic purine nucleoside phosphorylase: reaction with sugar-modified nucleoside substrates was written by Stoeckler, Johanna D.; Cambor, Carolyn; Parks, Robert E. Jr.. And the article was included in Biochemistry in 1980.Related Products of 13146-72-0 The following contents are mentioned in the article:
The kinetic parameters (Km and Vmax) of sugar-modified analogs of inosine and guanosine were determined with human erythrocyte purine nucleoside phosphorylase (I). Steric alterations at the 2′ and 3′ positions greatly lessened or abolished substrate activity. However, the 5′-deoxy- and 2′,5′-dideoxy-β-D-ribofuranosyl and the α-L-lyxosyl analogs were good substrates, indicating that the 5′-hydroxyl and the orientation of the 5′-hydroxymethyl group are not important for binding. The sugar phosphate analog, 5-doxyribose 1-phosphate, was synthesized from 5′-deoxyinosine with immobilized I, and its presence was verified by using it in the enzymic synthesis of 5′-deoxyguanosine. The adenosine versions of the 5′-modified analogs were also found to react with adenosine deaminase, albeit at <1% of Vmax. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Related Products of 13146-72-0).
9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Related Products of 13146-72-0
13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0