Prante, Olaf et al. published their research in Journal of Labelled Compounds and Radiopharmaceuticals in 2007 | CAS: 67341-43-9

Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Application of 67341-43-9

Chemoenzymatic n.c.a synthesis of the coenzyme UDP-2-deoxy-2-(18F)fluoro-α-D-glucopyranose as substrate of glycosyltransferases was written by Prante, Olaf; Hamacher, Kurt; Coenen, Heinz H.. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals on January 31,2007.Application of 67341-43-9 The following contents are mentioned in the article:

The development of 18F-labeling methods adopted to proteins and bioactive peptides is of great interest in radiopharmaceutical sciences. In order to provide 18F-labeled sugars as a polar prosthetic group for an enzymic 18F-labeling procedure, an appropriate nucleotide activated sugar is needed. Here, we present the radiosynthesis of n.c.a. UDP-2-deoxy-2-[18F]fluoro-α-D-glucopyranose (UDP-[18F]FDG) as a substrate for glycosyltransferases. The MacDonald synthesis of [18F]FDG-1-phosphate was successfully combined with an enzymic activation to obtain UDP-[18F]FDG directly in an aqueous medium located in the void volume of a solid phase cartridge. The radiochem. yield of UDP-[18F]FDG was 20% (based on [18F]fluoride) after a total synthesis time of 110 min. Thus, an intermediate was provided for the enzymic transfer of [18F]FDG using UDP-[18F]FDG as glycosyl donor making use of a suitable glycosyltransferase. This would represent a highly selective and mild 18F-labeling method for glycosylated biomols. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9Application of 67341-43-9).

Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Application of 67341-43-9

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