Day: November 10, 2022

Molecular mechanism of ATP versus GTP selectivity of adenylate kinase was written by Rogne, Per; Rosselin, Marie; Grundstroem, Christin; Hedberg, Christian; Sauer, Uwe H.; Wolf-Watz, Magnus. And the article was included in Proceedings of the National Academy of Sciences of the United States of America on March 20,2018.Recommanded Product: (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol The following contents are mentioned in the article:

Enzymic substrate selectivity is critical for the precise control of metabolic pathways. In cases where chem. related substrates are present inside cells, robust mechanisms of substrate selectivity are required. Here, we report the mechanism utilized for catalytic ATP vs. GTP selectivity during adenylate kinase (Adk)-mediated phosphorylation of AMP. Using NMR spectroscopy we found that while Adk adopts a catalytically competent and closed structural state in complex with ATP, the enzyme is arrested in a catalytically inhibited and open state in complex with GTP. X-ray crystallog. experiments revealed that the interaction interfaces supporting ATP and GTP recognition, in part, are mediated by coinciding residues. The mechanism provides an at. view on how the cellular GTP pool is protected from Adk turnover, which is important because GTP has many specialized cellular functions. In further support of this mechanism, a structure-function anal. enabled by synthesis of ATP analogs suggests that a hydrogen bond between the adenine moiety and the backbone of the enzyme is vital for ATP selectivity. The importance of the hydrogen bond for substrate selectivity is likely general given the conservation of its location and orientation across the family of eukaryotic protein kinases. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Recommanded Product: (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Recommanded Product: (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol

550-33-4;(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol;The future of 550-33-4;New trend of C10H12N4O4  ;function of 550-33-4

An inhibitor of mannosylation of retinyl-phosphate was written by Datema, Roelf; Schwarz, Ralph T.. And the article was included in Bioscience Reports on March 31,1984.COA of Formula: C15H23FN2O16P2  The following contents are mentioned in the article:

The guanosine disphosphate and uridine diphosphate esters of the antiviral sugar analog 2-deoxy-2-fluoro-D-glucose (GDP-FGlc [67341-45-1] and UDP-FGlc [67341-43-9]) were synthesized and tested as inhibitors of formation of lipid-linked sugars in cell-free extracts Formation of dolichol phosphate mannose  [55598-56-6] and of dolichol diphosphate di-N-acetylchitobiose were not inhibited by either sugar nucleotide. Formation of dolichol phosphate glucose  [55607-88-0] was inhibited by UDP-FGlc, but not by GDP-FGlc. Although GDP-FGlc did not inhibit formation of dolichol phosphate mannose, it did inhibit formation of retinyl phosphate mannose  [55722-25-3] from retinyl phosphate  [53859-19-1] and GDP-mannose. This inhibition was not reversed by exogenous retinyl phosphate, nor was FGlc from GDP-Glc incorporated into retinyl phosphate-linked derivatives As FGlc inhibits formation of dolichol phosphate mannose in intact cells, but does not decrease pool sizes of GDP-mannose and dolichol-phosphate (Datema, R., et al., 1980), that inhibition of formation of retinyl-phosphate mannose by one of the metabolites of FGlc, namely GDP-FGlc, may lead to decreased synthesis of dolichol phosphate mannose in FGlc-treated cells. This implies a role for vitamin A  [68-26-8] in the dolichol cycle of protein glycosylation. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9COA of Formula: C15H23FN2O16P2 ).

Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.COA of Formula: C15H23FN2O16P2 

67341-43-9;Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester;The future of 67341-43-9;New trend of C15H23FN2O16P2 ;function of 67341-43-9

Characterization of nucleoside phosphotransferase from Leishmania tropica was written by Shin, Il-Shik; Wataya, Yusuke. And the article was included in Nucleosides & Nucleotides on April 30,1995.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

Nucleoside phosphotransferase, a unique purine salvage enzyme, was partially purified from L. tropica. The purified preparation was nucleosidase-free. With this enzyme preparation, phosphorylation of 14 nucleosides involving 5 antileishmanial purine nucleoside analogs was investigated. Apparent Km values of the enzyme for 10 purine nucleosides were in the range of 5.7-8.4 μM, and those for 4 natural pyrimidine nucleosides were in the range of 14.0-16.9 μM. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

The chameleon of retaining glycoside hydrolases and retaining glycosyl transferases: the catalytic nucleophile was written by Stick, Robert V.; Watts, Andrew G.. And the article was included in Monatshefte fuer Chemie on April 30,2002.Application In Synthesis of Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester The following contents are mentioned in the article:

The authors report reliable procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogs for the study of the mechanism of action of retaining glycosyltransferases. The existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyltransferases are reviewed. Although the former has now been established beyond doubt, such is not the case with the latter. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9Application In Synthesis of Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester).

Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Application In Synthesis of Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester

67341-43-9;Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester;The future of 67341-43-9;New trend of C15H23FN2O16P2 ;function of 67341-43-9

Hypotensive compounds isolated from the dried body of Naja naja Kaouthia Lesson. I. Isolation of inosine as a hypotensive principle and structure-activity study of related compounds was written by Tsujibo, Hiroshi; Taniguchi, Toru; Koyama, Isao; Kubo, Mayuri; Inamori, Yoshihiko. And the article was included in Chemical & Pharmaceutical Bulletin on April 25,1986.Computed Properties of C10H12N4O4  The following contents are mentioned in the article:

From the dried body of N. naja, inosine (I) [58-63-9] was isolated as 1 of the 3 hypotensive compounds after Sephadex G-25 chromatog. and purification by preparative HPLC. Hypotensive activity was observed at dose levels higher than 0.5 mg/kg, the activity strongly increasing with increasing I dose. However, at 0.1 and 0.25 mg/kg, I showed only a transient effect and the blood pressure recovered to the original level within one min. 2′-Deoxyinosine  [890-38-0] and 3′-deoxyinosine  [13146-72-0] completely lacked hypotensive activity. Phosphorylation at the 3′- or 5′-position of the ribose moiety slightly decreased the hypotensive activity. However, inosine 5′-diphosphoribose  [86-04-4] showed the most potent hypotensive activity among compounds tested. Hydroxyl groups at C-2′ and C-3′ are necessary for I to show the activity. The importance of the ribose configuration of the sugar moiety of I for the hypotensive activity was demonstrated. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Computed Properties of C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Computed Properties of C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus was written by Hwu, Jih Ru; Lin, Shu-Yu; Tsay, Shwu-Chen; De Clercq, Erik; Leyssen, Pieter; Neyts, Johan. And the article was included in Journal of Medicinal Chemistry on April 14,2011.Safety of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol The following contents are mentioned in the article:

About 3% of world’s population is infected by the hepatitis C virus (HCV), for which prophylactic vaccine is not available yet. Nowadays, pegylated interferon-α and ribavirin are commonly used to treat HCV; unfortunately these drugs often produce significant side effects. Upon the desperate need of anti-HCV drugs, a plan to establish a new compound library was set that included leads with high antiviral activity, good hydrophilicity, yet low toxicity. Accordingly, 26 new conjugated nsds, e.g. I, were synthesized through the chem. coupling of various 9-(β-D-ribofuranosyl)purine-8-thiones with 3-(chloromethyl)coumarins bearing various substituents. A -SCH2- unit was used to link the coumarin and the purine moieties. The three hydroxyl groups at the 2′-, 3′-, and 5′-positions were selectively protected with an acyl or acetal group in these coumarin-purine ribofuranosides. Their anti-HCV and cytostatic determination assays were performed, and the structure-activity relationship was established. Three conjugates in the family of 8-(coumarin-3′-yl)methylthio-9-(β-D-ribofuranos-1”-yl)purine possessed an appealing ability to inhibit HCV replication with EC50 between 5.5 and 6.6 μM and EC90 of ∼20 μM. These data in the new compound library provide clues for the future in the development of anti-HCV leads for viral eradication. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Safety of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Safety of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol

550-33-4;(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol;The future of 550-33-4;New trend of C10H12N4O4  ;function of 550-33-4

The action of adenosine deaminase (E.C. 3.5.4.4.) on adenosine and deoxyadenosine acetates: the crucial role of the 5′-hydroxy group for the enzyme activity was written by Ciuffreda, Pierangela; Casati, Silvana; Santaniello, Enzo. And the article was included in Tetrahedron on May 12,2000.Formula: C10H12N4O4  The following contents are mentioned in the article:

From adenosine, 2′-deoxyadenosine, and 3′-deoxyadenosine all the acetates were prepared by lipase-catalyzed reactions. Only the acetates with free 5′-hydroxy group were deaminated by adenosine deaminase (ADA), confirming the crucial role of 5′-OH for the enzyme activity. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Formula: C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Formula: C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70 was written by Cheeseman, Matthew D.; Westwood, Isaac M.; Barbeau, Olivier; Rowlands, Martin; Dobson, Sarah; Jones, Alan M.; Jeganathan, Fiona; Burke, Rosemary; Kadi, Nadia; Workman, Paul; Collins, Ian; van Montfort, Rob L. M.; Jones, Keith. And the article was included in Journal of Medicinal Chemistry on May 26,2016.Recommanded Product: 550-33-4 The following contents are mentioned in the article:

HSP70 is a mol. chaperone and a key component of the heat-shock response. Because of its proposed importance in oncol., this protein has become a popular target for drug discovery, efforts which have as yet brought little success. This study demonstrates that adenosine-derived HSP70 inhibitors potentially bind to the protein with a novel mechanism of action, the stabilization by desolvation of an intramol. salt-bridge which induces a conformational change in the protein, leading to high affinity ligands. We also demonstrate that through the application of this mechanism, adenosine-derived HSP70 inhibitors can be optimized in a rational manner. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Recommanded Product: 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Recommanded Product: 550-33-4

550-33-4;(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol;The future of 550-33-4;New trend of C10H12N4O4  ;function of 550-33-4

Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase was written by Secrist, John A. III; Parker, William B.; Allan, Paula W.; Bennett, L. Lee Jr.; Waud, William R.; Truss, Jackie W.; Fowler, Anita T.; Montgomery, John A.; Ealick, Steven E.; Wells, Alan H.; Gillespie, G. Yancey; Gadi, V. K.; Sorscher, Eric J.. And the article was included in Nucleosides & Nucleotides on May 31,1999.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

During the last few years, many gene therapy strategies have been developed for various disease targets. The development of anticancer gene therapy strategies to selectively generate cytotoxic nucleoside or nucleotide analogs is an attractive goal. One such approach involves the delivery of herpes simplex virus thymidine kinase followed by the acyclic nucleoside analog ganciclovir. We have developed another gene therapy methodol. for the treatment of cancer that has several significant attributes. Specifically, our approach involves the delivery of E. coli purine nucleoside phosphorylase, followed by treatment with a relatively non-toxic nucleoside prodrug that is cleaved by the enzyme to a toxic compound This presentation describes the concept, details our search for suitable prodrugs, and summarizes the current biol. data. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Sequencing-by-ligation using oligonucleotide probes with 3′-thio-deoxyinosine was written by Pu, Dan; Chen, Jing; Bai, Yunfei; Tu, Jing; Xie, Hongmei; Wang, Wenjie; Xiao, Pengfeng; Lu, Zuhong. And the article was included in Journal of Biomedical Nanotechnology on May 31,2014.Product Details of 13146-72-0 The following contents are mentioned in the article:

We have developed a novel sequencing-by-ligation (SBL) system employing oligonucleotide probes containing 3′-thio-deoxyinosine on a microarray. The oligonucleotide probes were synthesized from 3′-S-(2-cyanoethyl-N,N-diisopropylphosphorothioamidite)-5′-O-(4,4′ dimet-hoxytrityl) deoxyinosine. The resultant probes could be cleaved chem. by aqueous silver ions under mild conditions, generating a 5′-terminal phosphate group in a degradation oligodeoxynucleotide fragment. This 5′-terminal phiosphate was used directly for detecting the corresponding bases in subsequent sequencing cycles. The queried bases in the template were identified with eight cycles of ligation and cleavage. The read length of our method could reach up to 40 bp with high accuracy. As this SBL method uses com. available enzymes and standard microarrays, it will be amenable to automation and adaptation by the research community. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Product Details of 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Product Details of 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0