Toxicity and metabolism of 3′-deoxyadenosine N1-oxide in mice and Ehrlich ascites tumor cells was written by Svendsen, Karsten Ramlov; Overgaard-Hansen, Kay; Frederiksen, Sune; Engelholm, Svend Aage; Pedersen, Niels Tinggaard; Vindelov, Lars Lindhardt. And the article was included in Cancer Chemotherapy and Pharmacology on June 30,1992.Name: 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:
The toxic effect of 3′-deoxyadenosine N1-oxide (DANO) on mice, on their organs, and on Ehrlich ascites tumor cells was studied. In both healthy and tumor-bearing animals, the i.p. LD10 of DANO was about 300 mg/kg for 4 days in the Theiller mouse strain. In the NMRI strain, a markedly higher LD10 value (675 mg/kg for 5 days) was found. At nonlethal doses (250 mg/kg for 4 days), reversible neurol. symptoms were observed on days 4-12 after treatment, but no macroscopical or microscopical changes were detected in the brain, heart, thymus, lung, lymph nodes, spleen, liver, kidney, bone marrow, or gastrointestinal tract. At doses of 450 mg/kg for 4 days, severe neurol. symptoms, atony of the gastrointestinal canal, and damage to the kidney and liver were found. Even at doses that were lethal to mice, no histopathol. changes were observed in the bone marrow or in the gastrointestinal tract. After i.p. injection of DANO, the maximal blood plasma concentration was reached after 10 min, after which it declined showing a half-life of about 40 min. A transient accumulation of 3′-deoxyadenosine triphosphate (3′-dATP) was observed within 24 h in the liver and kidney, with the maximal concentration being reached after about 2-3 h. DANO was excreted partly as the unchanged substance and partly as 3′-deoxyinosine metabolite within 24 h. Flow-cytometric DNA anal. of Ehrlich tumor cells treated in vitro or in vivo with DANO revealed no therapy-induced perturbations of the cell cycle, which indicates that the cells were killed randomly during all phases of the cycle. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Name: 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).
9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Name: 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol
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