Preparation of 2-deoxy-2-fluoro-glycoside-bound nucleotides as glycosyltransferase inhibitors was written by Wong, Chi-huey; Hayashi, Takashi. And the patent was published on June 18,1998.HPLC of Formula: 67341-43-9 The following contents are mentioned in the patent:
Nucleotide linked 2-deoxy-2-fluoroglycosides are employed as potent competitive inhibitors of glycosyltransferases. More particularly, uridine-5′-diphospho-2-deoxy-2-fluoro-galactose (UDP-2F-Gal), guanidine-5′-diphospho-2-deoxy-2-fluoro-L-fucose (GDP-2F-Fuc), uridine-5′-diphospho-2-deoxy-2-fluoro-D-glucose (UDP-2F-Glu), guanosine-5′-diphospho-2-deoxy-2-fluoro-D-mannose (GDP-2F-Man), cytosine-5′-monophospho-2-deoxy-2-fluoro-D-sialic acid, and cytosine-5′-monophospho-2-deoxy-2-KDO may be employed as inhibitors of β-1,4-galactosyltransferase, α-1,3-fucosyltransferase, glucosyltransferases, N-acetylglucosaminyltransferases, α-mannosyltransferases, α-sialyltransferases, and KDO-transferases, resp. Synthesis of nucleotide-linked-2-deoxy-2-fluoroglycosides is achieved using either chemoenzymic or chem. methodologies. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9HPLC of Formula: 67341-43-9).
Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.HPLC of Formula: 67341-43-9
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem