Preparation of cyclic dinucleotides as STING agonists was written by Beigelman, Leonid; Bignan, Gilles; Connolly, Peter J.; Edwards, James Patrick; Emanuel, Stuart; Laquerre, Sylvia; Richter, Mark; Schepens, Wim Gert Griet; Thatikonda, Santhosh Kumar; Thuring, Johannes Wilhelmus John Fitzgerald; Viellevoye, Marcel; Wang, Guangyi; Zhong, Minghong. And the patent was published on June 20,2019.Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol The following contents are mentioned in the patent:
Cyclic dinucleotides I, wherein B1 and B2 are independently nucleobase; R1a is H, OH, F, alkoxy; R1b is H, F, OH; provided that when R1b is F, R1a is H or F; R1c is H or Me; R2a is H,, OH, F, alkoxy; R2b is H, F, or OH; provided that when R2b is F, R2a is H or F; R2c is H, F, CH3, or CH2F; X1 and X2 are the group consisting of O, S, and CH2; Y and Y1 are each independently absent or O or NH; Z and Z1 are the group consisting of O and NH; M and M1 are independently SO2, substituted phosphate, substituted thiophosphate, were prepared and used for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Thus, cyclic dinucleotide II was prepared and used as antitumor and antiviral agent and vaccine. Cyclic dinucleotides are used for treating of diseases, syndrome, melanoma, colon cancer, breast cancer, prostate cancer, lung cancer, and fibrosarcoma, hepatitis B. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol).
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem