Day: November 9, 2022

Methods for preparing and using tagged nucleotide compositions for nanopore based sequencing was written by Fuller, Carl W.; Kumar, Shiv; Ju, Jingyue; Davis, Randall; Chen, Roger. And the patent was published on October 1,2015.Formula: C10H12N4O4   The following contents are mentioned in the patent:

This disclosure provides systems and methods for attaching nano pore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides. Provided herein are nucleotides with attached tags and methods for attaching tags to nucleotides. The tags can be attached by chem. reactions, such as click chem. In an aspect, the present disclosure provides a tagged nucleotide, comprising a poly-phosphate moiety having a terminal phosphate and a tag covalently coupled to the terminal phosphate of the nucleotide by a triazole, a 1,2-diazine, a disulfide, a secondary amine, a hydrazone, a thio-acetamide, or a maleimide-thioadduct. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Formula: C10H12N4O4  ).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Formula: C10H12N4O4  

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Microneedle compositions and methods of delivery using the same was written by Artzi, Natalie; Dosta, Pere; Puigmal, Nuria. And the patent was published on September 1,2022.SDS of cas: 550-33-4 The following contents are mentioned in the patent:

The present disclosure describes microneedle array compositions comprising a plurality of microneedles projecting from a substrate. Each microneedle of the plurality of microneedles comprise a penetrating tip and a base that is integrally connected with the substrate, wherein each microneedle of the plurality of microneedles is a porous microneedle composed of a degradable hyaluronic acid polymer comprising a disulfide bond. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4SDS of cas: 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.SDS of cas: 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Copper cleaning and protection formulations was written by Koji, Yukichi; Hirashima, Ryoichi; Saito, Hideaki. And the patent was published on September 19,2013.Category: tetrahydrofurans The following contents are mentioned in the patent:

A cleaning composition for cleaning post-chem. mech. polishing residue and contaminants from a microelectronic device without compromising the low-k dielec. material or the copper interconnect material comprises at least one solvent, at least one corrosion inhibitor, at least one polyamine species, and at least one quaternary base, wherein the at least one polyamine species is at least one of an aliphatic polyamine or a cyclic polyamine. A composition for cleaning copper wire semiconductors (removing benzotriazole residue) comprises 0.7 weight% triethanolamine, 0.03 weight% gallic acid, 0.16 weight% tetramethylammonium hydroxide and 99.1 weight% water. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Category: tetrahydrofurans).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Improving the biological activity of siRNA through modulation of its thermodynamic profile was written by Maier, Martin; Addepalli, Haripriya; Zhang, Ligang; Peng, Paul; Manoharan, Muthiah; Bettencourt, Brian; Hinkle, Greg. And the patent was published on September 9,2011.Related Products of 550-33-4 The following contents are mentioned in the patent:

The present invention describes the combination of thermally stabilizing and destabilizing chem. modifications and sequence alterations incorporated in specific regions of the duplex to optimize the thermodn. profile of a given siRNA duplex and to further improve its silencing activity. The average internal stability profile of highly active siRNAs is highly specific and clearly distinguishable from non-functional ones. With large numbers of possible siRNAs against a given target, it is generally possible to identify potent siRNAs with a close-to-optimal thermodn. profile. However in many cases, the number of possible siRNAs against a given target RNA is limited due to short target RNA sequence or poor sequence homol. across species (for cross-reactive siRNAs). In these cases, modulating the thermal stability of the duplex by selectively placing thermally stabilizing and/or destabilizing modifications could be particularly useful to generate active siRNAs. The choice of modification and their position will depend on the thermodn. profile of the siRNA to be modified. Thermally destabilizing chem. modifications such as abasic residues, universal bases with reduced or abolished capability to form hydrogen bonds with opposing bases (e.g. 2,4-difluorotoluyl, 5-nitroindole), or unlocked nucleic acids in the low thermal stability region of the duplex (e.g., region around the cleavage site or within the 5′-half of the antisense strand), or the placement of one or more mismatches in this low thermal stability region or both, in addition to chem. modifications, such as locked nucleic acid or 2′-modified RNA, to further stabilize the high thermal stability region at or near the 3′-end of the antisense strand will improve the potency of siRNA, including the silencing activity of siRNA. Thus, IC50 values are derived using results from HeLa cell-based PTEN assay is siRNAs targeting firefly luciferase. The results confirm that local destabilization of the central region of the sense strand with mismatch base pairings or modified nucleobases can lead to substantial potency enhancements. For this particular sequence, mismatched base pairings or introduction of 2,4-difluorotoluyl ribonucleotide in positions 9 and 10 were found to significantly enhance potency over the parent unmodified compound This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Related Products of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Related Products of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Selective oxidation of 5-methylcytosine by tet-family proteins was written by Rao, Anjana; Tahiliani, Mamta; Koh, Kian Peng; Agarwal, Suneet; Iyer, Aravind. And the patent was published on August 25,2015.Product Details of 67341-43-9 The following contents are mentioned in the patent:

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9Product Details of 67341-43-9).

Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Product Details of 67341-43-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Post chemical mechanical polishing formulations and method of use was written by Liu, Jun; Barnes, Jeffrey A.; Zhang, Peng; Sun, Laisheng; Medd, Steven. And the patent was published on August 6,2015.Computed Properties of C10H12N4O4   The following contents are mentioned in the patent:

A cleaning composition and process for cleaning post-chem. mech. polishing (CMP) residue and contaminants from a microelectronic device having said residue and contaminants thereon. The cleaning compositions are substantially devoid of amines and ammonium-containing salts. The composition achieves highly efficacious cleaning of the post-CMP residue and contaminant material from the surface of the microelectronic device without compromising the low-k dielec. material or the copper interconnect material. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Computed Properties of C10H12N4O4  ).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Computed Properties of C10H12N4O4  

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Method for reducing primer dimer formation and increasing amplification efficiency was written by Lee, Young Jo; Kim, Dae Young. And the patent was published on July 5,2018.Reference of 550-33-4 The following contents are mentioned in the patent:

The present invention relates to a method for amplifying at least three target nucleic acid mols. with reduced primer dimer formation in a multiplex amplification reaction. The method of present invention can inhibit primer dimer formation and hence generation of nonspecific amplification products in an effective manner in a multiplex amplification reaction for at least three target nucleic acid mols. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Reference of 550-33-4).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Reference of 550-33-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Preparation of 2-deoxy-2-fluoro-glycoside-bound nucleotides as glycosyltransferase inhibitors was written by Wong, Chi-huey; Hayashi, Takashi. And the patent was published on June 18,1998.HPLC of Formula: 67341-43-9 The following contents are mentioned in the patent:

Nucleotide linked 2-deoxy-2-fluoroglycosides are employed as potent competitive inhibitors of glycosyltransferases. More particularly, uridine-5′-diphospho-2-deoxy-2-fluoro-galactose (UDP-2F-Gal), guanidine-5′-diphospho-2-deoxy-2-fluoro-L-fucose (GDP-2F-Fuc), uridine-5′-diphospho-2-deoxy-2-fluoro-D-glucose (UDP-2F-Glu), guanosine-5′-diphospho-2-deoxy-2-fluoro-D-mannose (GDP-2F-Man), cytosine-5′-monophospho-2-deoxy-2-fluoro-D-sialic acid, and cytosine-5′-monophospho-2-deoxy-2-KDO may be employed as inhibitors of β-1,4-galactosyltransferase, α-1,3-fucosyltransferase, glucosyltransferases, N-acetylglucosaminyltransferases, α-mannosyltransferases, α-sialyltransferases, and KDO-transferases, resp. Synthesis of nucleotide-linked-2-deoxy-2-fluoroglycosides is achieved using either chemoenzymic or chem. methodologies. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9HPLC of Formula: 67341-43-9).

Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.HPLC of Formula: 67341-43-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Preparation of cyclic dinucleotides as STING agonists was written by Beigelman, Leonid; Bignan, Gilles; Connolly, Peter J.; Edwards, James Patrick; Emanuel, Stuart; Laquerre, Sylvia; Richter, Mark; Schepens, Wim Gert Griet; Thatikonda, Santhosh Kumar; Thuring, Johannes Wilhelmus John Fitzgerald; Viellevoye, Marcel; Wang, Guangyi; Zhong, Minghong. And the patent was published on June 20,2019.Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol The following contents are mentioned in the patent:

Cyclic dinucleotides I, wherein B1 and B2 are independently nucleobase; R1a is H, OH, F, alkoxy; R1b is H, F, OH; provided that when R1b is F, R1a is H or F; R1c is H or Me; R2a is H,, OH, F, alkoxy; R2b is H, F, or OH; provided that when R2b is F, R2a is H or F; R2c is H, F, CH3, or CH2F; X1 and X2 are the group consisting of O, S, and CH2; Y and Y1 are each independently absent or O or NH; Z and Z1 are the group consisting of O and NH; M and M1 are independently SO2, substituted phosphate, substituted thiophosphate, were prepared and used for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Thus, cyclic dinucleotide II was prepared and used as antitumor and antiviral agent and vaccine. Cyclic dinucleotides are used for treating of diseases, syndrome, melanoma, colon cancer, breast cancer, prostate cancer, lung cancer, and fibrosarcoma, hepatitis B. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Application In Synthesis of (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Non-DNA base-containing polynucleotide compositions and their use for the modulation of immune responses was written by Phillips, Nigel C.; Filion, Mario C.. And the patent was published on May 12,2011.Synthetic Route of C10H12N4O4   The following contents are mentioned in the patent:

The present invention provides compositions comprising synthetic non-DNA base-containing polynucleotide sequences of 3 to 30 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases, in combination with a pharmaceutically acceptable vehicle, particularly one or more adjuvant vehicle, and one or more antigen. The present invention relates to methods of administering these compositions for inducing or modulating an immune response in vitro or in vivo, and particularly for activating antigen presenting cells. The present invention relates to compositions comprising synthetic non-DNA base-containing polynucleotides, a pharmaceutically acceptable vehicle and optionally one or more antigens, and their use to modulate immune responses. Several of the compositions of the present invention permit lower doses of antigen to be used in a vaccine formulation. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Synthetic Route of C10H12N4O4  ).

(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Synthetic Route of C10H12N4O4  

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem