Antiprotozoal activity of 3′-deoxyinosine. Inverse correlation to cleavage of the glycosidic bond was written by Moorman, Allan R.; LaFon, Stephen W.; Nelson, Donald J.; Carter, Heidi H.. And the article was included in Biochemical Pharmacology on July 5,1991.Electric Literature of C10H12N4O4 The following contents are mentioned in the article:
Two nucleosides related to the known antiprotozoal agent, allopurinol β-D-riboside) (I) were prepared and evaluated against Leishmania donovani, Trypanosoma cruzi, and T. gambiense. 3′-Deoxyinosine (II) exhibited potent antiprotozoal activity against the three protozoal pathogens with minimal toxicity for host cells. It was especially effective against the Columbia strain of T. cruzi reported to be resistant to I. The antiprotozoal activity of II appeared to be inversely related to the rate of cleavage of the glycosidic bond, as shown by metabolic profiles of II in the various pathogenic hemoflagellates and host cells. Combining the key structural elements of I and II led to the synthesis of 3′-deoxyallopurinol β-D-riboside (III) which was inactive as an antiprotozoal agent. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Electric Literature of C10H12N4O4 ).
9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Electric Literature of C10H12N4O4
13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0