Month: October 2022

Wappes, Ethan A.; Vanitcha, Avassaya; Nagib, David A. published the artcile< β C-H di-halogenation via iterative hydrogen atom transfer>, SDS of cas: 5455-94-7, the main research area is geminal dihalide regioselective preparation; imidate preparation photochem tandem dihalogenation hydrogen transfer.

A radical relay strategy for mono- and di-halogenation (iodination, bromination, and chlorination) of sp3 C-H bonds was developed. This is the first example of β C-H di-halogenation is achieved through sequential C-H abstraction by iterative, hydrogen atom transfer (HAT). A double C-H functionalization was enabled by in-situ generated imidate radicals, which facilitate selective N to C radical translocation and tunable C-X termination. The versatile, geminal di-iodide products were further elaborated to β ketones and vinyl iodides. Mechanistic experiments explained the unique di-functionalization selectivity of this iterative HAT pathway, wherein the second C-H iodination is twice as fast as the first.

Chemical Science published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, SDS of cas: 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Weerachawanasak, Patcharaporn; Krawmanee, Pacharaporn; Inkamhaeng, Weerachat; Cadete Santos Aires, Francisco J.; Sooknoi, Tawan; Panpranot, Joongjai published the artcile< Development of bimetallic Ni-Cu/SiO2 catalysts for liquid phase selective hydrogenation of furfural to furfuryl alcohol>, Application of C5H10O2, the main research area is development bimetallic nickel copper SiO2 catalyst liquid hydrogenation furfural.

Bimetallic Ni-Cu/SiO2 catalysts with different Cu loading (2-5 wt%) were developed for liquid phase selective hydrogenation of furfural to furfuryl alc. Among these, bimetallic 2%Ni-X%Cu/SiO2 (X = 2, 5) catalysts exhibited better catalytic performances than monometallic 2%Ni/SiO2 and 2%Cu/SiO2. Moreover, the bimetallic 2%Ni-5%Cu/SiO2 catalyst showed the best catalytic performance with 94% of furfural conversion and 64% of furfuryl alc. selectivity. The synergetic effect of NiCu alloy particles that are present on bimetallic Ni-Cu/SiO2 catalysts change the adsorption configuration of furfural on the catalyst surface resulting in high catalytic performance in liquid phase selective hydrogenation of furfural to furfuryl alc.

Catalysis Communications published new progress about Hydrogenation catalysts. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ruan, Luna; Zhang, Huan; Zhou, Man; Zhu, Lihua; Pei, An; Wang, Jiexiang; Yang, Kai; Zhang, Chuanqun; Xiao, Suqun; Chen, Bing Hui published the artcile< A highly selective and efficient Pd/Ni/Ni(OH)2/C catalyst for furfural hydrogenation at low temperatures>, Quality Control of 97-99-4, the main research area is furfural hydrogenation nickel palladium carbon nanocatalyst furfuryl alc.

Hydrogenation of furfural (FF) produces a train of products such as furfuryl alc. (FFA), tetrahydrofurfuryl alc. (THFFA) and 2-methylfuran (2-MF). The Pd/Ni/Ni(OH)2/C nanocatalyst was successfully prepared under mild conditions by hydrazine hydrate reduction and galvanic replacement methods. Pd/Ni/Ni(OH)2/C had much higher conversion of furfural and selectivity toward furfuryl alc. for the selective hydrogenation of furfural than the monometallic catalysts (eg. Pd/C or Ni/C) due to its unique nanostructure of palladium island-on-Ni/Ni(OH)2 nanoparticles and thus the synergy effect between Pd, Ni and Ni(OH)2 related species. The proposed mechanism of the synergistic effect was also provided. Pd/Ni/Ni(OH)2/C showed high selectivity (90.0% or 92.4%) to furfuryl alc. at quite low reaction temperatures (5°C or 10°C), and had good stability. We used various characterization techniques (XRD, HRTEM, STEM-EDS elemental mapping and line-scanning, XPS, HS-LEIS) to compare the nanostructural differences between the monometallic and bimetallic catalysts as well as to explain the possible reasons for the superior performance of Pd/Ni/Ni(OH)2/C to corresponding monometallic catalysts.

Molecular Catalysis published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Quality Control of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sasidharan, Sreeja; Pochinda, Simon; Elgaard-Joergensen, Paninnguaq Naja; Rajamani, Sudha; Khandelia, Himanshu; Raghunathan, V. A. published the artcile< Interaction of the mononucleotide UMP with a fluid phospholipid bilayer>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is mononucleotide uridine monophosphate phospholipid cryogenic SEM.

Interaction between mononucleotides and lipid membranes is believed to have played an important role in the origin of life on Earth. Studies on mononucleotide-lipid systems hitherto have focused on the influence of the lipid environment on the organization of the mononucleotide mols., and the effect of the latter on the confining medium has not been investigated in detail. We have probed the interaction of the mononucleotide, UMP (UMP), and its disodium salt (UMPDSS) with fluid dimyristoylphosphatidylcholine (DMPC) membranes, using small-angle X-ray scattering (SAXS), cryogenic SEM (cryo-SEM) and computer simulations. UMP adsorbs and charges the lipid membrane, resulting in the formation of unilamellar vesicles in dilute solutions Adsorption of UMP reduces the bilayer thickness of DMPC. UMPDSS has a much weaker effect on interbilayer interactions. These observations are in very good agreement with the results of an all-atom mol. dynamics simulation of these systems. In the presence of counterions, such as Na+, UMP forms small aggregates in water, which bind to the bilayer without significantly perturbing it. The phosphate moiety in the lipid headgroup is found to bind to the hydrogens from the sugar ring of UMP, while the choline group tends to bind to the two oxygens from the nucleotide base. These studies provide important insights into lipid-nucleotide interactions and the effect of the nucleotide on lipid membranes.

Soft Matter published new progress about Boltzmann constant. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Song, Yongzhi; Yuan, Lili; Wang, Zhiyuan; Yang, Shiyong published the artcile< Photo-aligning of polyimide layers for liquid crystals>, Name: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is photoaligning polyimide layer liquid crystal display.

A series of soluble and highly transparent semi-alicyclic polyimides (PIs) with designed flexible linkages have been synthesized derived from an alicyclic aromatic dianhydride (1,2,3,4-cyclobutanetetracarboxylic dianhydride, CBDA) and various aromatic ether-bridged diamines. The semi-alicyclic PIs were evaluated as the photo-alignment layers of liquid crystal (LC) mols. in liquid crystal display (LCD). Exptl. results indicate that the photo-alignment characteristics of LC mols. induced by the photo-aligned PI layers and the electro-optical (EO) properties of the LC cell devices are closely related with PI backbone structures. The retardation of the photo-aligned PI layers is correlated with the UV absorption intensity of PI at 220 to approx. 330 nm. The higher UV absorption intensity PI has, the higher retardation and lower pre-tilt angle the photo-aligned PI layer exhibits. The defect-free and photo-aligned PI layer could result into the uniform LC texture, which is highly desired for in-plane switching (IPS) mode LCD devices. In comparison, PI layer containing trifluoromethyl moiety shows poor photo-aligning performance because of the strong electronic withdrawing effect of the fluorinated linkage.

Polymers for Advanced Technologies published new progress about Electrooptical instruments. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Name: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Takada, Kenji; Noda, Takumi; Kobayashi, Takuya; Harimoto, Toyohiro; Singh, Maninder; Kaneko, Tatsuo published the artcile< Synthesis of pH-responsive polyimide hydrogel from bioderived amino acid>, Reference of 4415-87-6, the main research area is bioderived amino acid diamino alpha truxillic tetracarboxylic dianhydride polyimide.

A series of biobased polyimides bearing a structure derived from a predetermined tetracarboxylic dianhydride was synthesized. By ionizing the COOH group of the side chain with potassium hydroxide, four kinds of polyimides were solubilized in water, and the water-soluble polyimides were cast onto films over an aqueous solution, leading to higher optical transparency than that of non-water-soluble polyimides. 1H NMR measurements of the polyimides revealed no residual reactants from the polymerization process or side-chain modification. Partial crosslinking of the water-soluble polyimide chains by condensation of the carboxylate side chain with an amino acid-based diamine such as 4-aminophenylalanine or 4,4′-diamino-α-truxillic acid induced the formation of polyimide hydrogels. The remaining COOK groups of the obtained hydrogel were protonated/deprotonated by changing the pH, accompanied by reversible shrinking and swelling.

Polymer Journal (Tokyo, Japan) published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Reference of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brandao, Tiago A. S.; Richard, John P. published the artcile< Orotidine 5'-monophosphate decarboxylase: The operation of active site chains within and across protein subunits>, Synthetic Route of 58-97-9, the main research area is orotidine monophosphate decarboxylase Saccharomyces active site subunit substrate.

The D37 and T100′ side chains of orotidine 5′-monophosphate decarboxylase (OMPDC) interact with the C-3′ and C-2′ ribosyl hydroxyl groups, resp., of the bound substrate. We compare the intra-subunit interactions of D37 with the inter-subunit interactions of T100′ by determining the effects of the D37G, D37A, T100’G, and T100’A substitutions on the following: (a) kcat and kcat/Km values for the OMPDC-catalyzed decarboxylations of OMP and 5-fluoroorotidine 5′-monophosphate (FOMP) and (b) the stability of dimeric OMPDC relative to the monomer. The D37G and T100’A substitutions resulted in 2 kcal mol-1 increases in ΔG† for kcat/Km for the decarboxylation of OMP, while the D37A and T100’G substitutions resulted in larger 4 and 5 kcal mol-1 increases, resp., in ΔG†. The D37G and T100’A substitutions both resulted in smaller 2 kcal mol-1 decreases in ΔG† for the decarboxylation of FOMP compared to that of OMP. These results show that the D37G and T100’A substitutions affect the barrier to the chem. decarboxylation step while the D37A and T100’G substitutions also affect the barrier to a slow, ligand-driven enzyme conformational change. Substrate binding induces the movement of an α-helix (G’98-S’106) toward the substrate C-2′ ribosyl hydroxy bound at the main subunit. The T100’G substitution destabilizes the enzyme dimer by 3.5 kcal mol-1 compared to the monomer, which is consistent with the known destabilization of α-helixes by the internal Gly side chains [Serrano, L., et al. (1992) Nature, 356, 453-455]. We propose that the T100’G substitution weakens the α-helical contacts at the dimer interface, which results in a decrease in the dimer stability and an increase in the barrier to the ligand-driven conformational change.

Biochemistry published new progress about Conformational transition. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Synthetic Route of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Fan, Yi; Sun, Guangrong; Kaw, Han Yeong; Zhu, Lizhong; Wang, Wei published the artcile< Analytical characterization of nucleotides and their concentration variation in drinking water treatment process>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is nucleotide concentration variation solid phase extraction drinking water treatment; Disinfection byproducts (DBPs); Drinking water; Nucleotides; Precursors; Solid phase extraction (SPE); Ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).

Nucleotides, as the basic building blocks of nucleic acids, widely exist in aqueous environment. In this study, we developed a solid phase extraction-high performance liquid chromatog.-tandem mass spectrometry (SPE-UPLC-MS/MS) method for the anal. of 5′-adenosine monophosphate (AMP), 5′-uridine monophosphate (UMP), 5′-cytidine monophosphate (CMP) and 5′-guanosine monophosphate (GMP). The method achieved limits of detection (LODs) of 0.1-1.0 ng/L, and recoveries of 85-95% for the four tested nucleotides. The occurrence and concentrations of the four nucleotides in water from eight representative drinking water treatment and distribution systems in China were determined using this method. All four nucleotides were detectable in water treatment plant (WTP) influent and effluent, at concentrations of up to 30 ng/L and with occurrence frequency of around 90%. The concentrations of identified nucleotides increased 3-10 times after 10 km of water age in the water distribution system. Biol. filters and coagulation increased the concentrations of nucleotides, conversely, active carbon, ozonation, and ultrafiltration membrane removed nucleotides in water. The effects of active carbon and coagulation were further confirmed using laboratory-controlled experiment In addition, monochlorinated nucleotides were identified as the chlorination products of nucleotides.

Science of the Total Environment published new progress about Coagulation. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Niro, Giuliana; Weck, Stefanie C.; Ducho, Christian published the artcile< Merging Natural Products: Muraymycin-Sansanmycin Hybrid Structures as Novel Scaffolds for Potential Antibacterial Agents>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is muraymycin sansanmycin hybrid structure scaffold antibacterial agent; antibiotics; hybrid structures; natural products; nucleosides; structure-activity relationship.

To overcome bacterial resistances, the need for novel antimicrobial agents is urgent. The class of so-called nucleoside antibiotics furnishes promising candidates for the development of new antibiotics, as these compounds block a clin. unexploited bacterial target: the integral membrane protein MraY, a key enzyme in cell wall (peptidoglycan) biosynthesis. Nucleoside antibiotics exhibit remarkable structural diversity besides their uridine-derived core motifs. Some sub-classes also show specific selectivities towards different Gram-pos. and Gram-neg. bacteria, which are poorly understood so far. Herein, the synthesis of a novel hybrid structure is reported, derived from the 5′-defunctionalized uridine core moiety of muraymycins and the peptide chain of sansanmycin B, as a new scaffold for the development of antimicrobial agents. The reported muraymycin-sansanmycin hybrid scaffold showed nanomolar activity against the bacterial target enzyme MraY, but displayed no significant antibacterial activity against S. aureus, E. coli, and P. aeruginosa.

Chemistry – A European Journal published new progress about Antibacterial agent resistance. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yang, Songqiu; Zhang, Yan; Zhao, Xi published the artcile< Change of Initial Yield of a Hydrated Electron with Uridine Monophosphate Concentration Is Related to the Excitation Photon Energy in Transient Absorption Spectroscopy>, Quality Control of 58-97-9, the main research area is hydrated electron uridine monophosphate excitation photon transient absorption.

The initial yield of a hydrated electron (eaq-) in a solution under laser pulse irradiation was investigated by pump-probe transient absorption spectroscopy. The initial quantum yield of eaq- varies with the concentration of uridine monophosphate (UMP). The variation of the concentration of eaq- is often used to study the prehydrated electron (epre-) and eaq- attachment to UMP. The results of 320 and 260 nm excitations were compared. It was found that with the increase of UMP concentration, the initial yield of eaq- increases at 320 nm excitation, but decreases at 260 nm excitation. The further anal. indicates that some of the epre- attachments to UMP before solvation at 260 nm excitation result in the decrease of the eaq- yield. In addition, the absorption of UMP to 260 nm also causes the decrease of the eaq- yield. After the excitation at 320 nm, the phosphate group of UMP can release electrons more easily than that of water mols. by two-photon absorption, and therefore the eaq- yield increases. With the increase of UMP concentration, the decay rate of eaq- increases because eaq- is captured by UMP. The change of excitation photon does not affect the reaction rate of eaq- attachment to UMP. The longer lifetime of eaq- obtained at 260 nm excitation than 320 nm excitation is induced by the larger eaq- escape probability at 260 nm excitation. Our results show that the femtosecond pulse pump-probe transient absorption spectroscopy method should be cautiously used because of its complexity in studying the epre- attachment to nucleotides in an aqueous solution

Journal of Physical Chemistry B published new progress about Electron attachment. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Quality Control of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem