Month: October 2022

《IRMOF-3 biological activity enhancement by post-synthetic modification》 was written by Abdelhameed, Reda M.; Darwesh, Osama M.; Rocha, Joao; Silva, Artur M. S.. Recommanded Product: 696-59-3This research focused onzinc metal organic framework IRMOF3 derivative nanoparticle antimicrobial. The article conveys some information:

The growing resistance of pathogens to conventional antibiotics has become a public health problem requiring novel effective solutions In this context, metal-organic frameworks (MOFs) are attracting attention because they can act as reservoirs releasing metal ions with antibacterial properties. This action is reminiscent of that proposed for metal- and metal oxide-nanoparticles but different from the action of antibiotics. These features make MOFs promising candidates for pharmaceutical and biomedical applications. Here, IRMOF-3 was modified with 2,5-dimethoxytetrahydrofuran, N,N’-disuccinimidyl carbonate, acryloyl chloride, and phthalaldehyde to produce, resp., IRMOF-3-FU, IRMOF-3-SU, IRMOF-3-AC, IRMOF-3-DL in 38 to 90% yields. Remarkably, the biol. activity of these compounds evaluated against various bacterial and fungal strains is higher than the activity of com. antibiotics. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Recommanded Product: 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Recommanded Product: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2021,World News of Natural Sciences included an article by James-Okoro, Paula-Peace O.; Iheagwam, Franklyn N.; Sholeye, Mariam I.; Umoren, Itoroobong A.; Adetuyi, Babatunde O.; Ogundipe, Adebanke E.; Braimah, Adefoyeke A.; Adekunbi, Tobi S.; Ogunlana, Oluseyi E.; Ogunlana, Olubanke O.. Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one. The article was titled 《Phytochemical and in vitro antioxidant assessment of Yoyo bitters》. The information in the text is summarized as follows:

In this paper, herbal bitters are widely used due to their numerous acclaimed health benefits in many Nigerian homes; however, many have not been subjected to scientific scrutiny. The aim of this study was to determine the phytochem. composition and antioxidant capacity of a non-alc. polyherbal formulation, Yoyo bitters, towards validating its broad pharmacol. claims. The phytochem. components of Yoyo bitters were ascertained by phytochem. screening assays and gas chromatog.-mass spectrometry (GC-MS). The antioxidant activity was investigated in vitro using 2,2-diphenyl-1-picryhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) scavenging activity, total antioxidant capacity (TAC) and ferric reducing antioxidant power (FRAP) assays. Qual. phytochem. anal. of Yoyo bitters showed the presence of saponins, tannins, flavonoids, terpenoids, cardiac glycosides and anthocyanins. The total phenols, flavonoids, flavanols, tannins and carotenoids content were 14.741 ± 0.64 mg GAE/mL, 0.152 ± 0.01 mg RE/mL, 0.437 ± 0.02 mg RE/mL, 0.368 ± 0.04 mg TAE/mL and 0.016 ± 0.00 mg CAE/mL resp. GC-MS chromatogram revealed the presence of forty-three (43) phytochem. compounds with D-allose (41.81%), 1,6-anhydro-beta-D-glucofuranose (24.15%), 5-hydroxymethylfurfural (8.02%) and Z-6-pentadecen-1-ol acetate (3.50%) as the most abundant constituents. Yoyo bitters demonstrated effective antioxidant activity against DPPH and H2O2 with IC50 values of 0.492 mg/mL and 0.629 mg/mL resp. compared to ascorbic acid of 0.161 mg/mL and 0.130 mg/mL resp. Total antioxidant capacity and ferric reducing antioxidant power of Yoyo bitters were 0.432 mg AAE/mL and 2.236 mg AAE/mL resp. This study validates the antioxidant capacity of Yoyo bitters and provides chem. basis for its acclaimed pharmacol. actions.3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,Current Issues in Molecular Biology included an article by Kiddane, Anley Teferra; Kang, Min-Jae; Ho, Truc Cong; Getachew, Adane Tilahun; Patil, Maheshkumar Prakash; Chun, Byung-Soo; Kim, Gun-Do. Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one. The article was titled 《Anticancer and Apoptotic Activity in Cervical Adenocarcinoma HeLa Using Crude Extract of Ganoderma applanatum》. The information in the text is summarized as follows:

Cancer is currently one of the foremost health challenges and a leading cause of death worldwide. Cervical cancer is caused by cofactors, including oral contraceptive use, smoking, multiparity, and HIV infection. One of the major and considerable etiologies is the persistent infection of the oncogenic human papilloma virus. G. applanatum is a valuable medicinal mushroom that has been widely used as a folk medicine for the treatment and prevention of various diseases. In this study, we obtained crude extract from G. applanatum mushroom with a subcritical water extraction method; cell viability assay was carried out and the crude extract showed an antiproliferative effect in HeLa cells with IC50 of 1.55 ± 0.01 mg/mL; however, it did not show any sign of toxicity in HaCaT. Protein expression was detected by Western blot, stability of IκBα and downregulation of NFκB, IKKα, IKKβ, p-NFκB-65(Ser 536) and p-IKKα/β(Ser 176/180), suggesting loss of survival in a dose-dependent manner. RT-qPCR revealed RNA/mRNA expression; fold changes of gene expression in Apaf-1, caspase-3, cytochrome-c, caspase-9, Bax and Bak were increased, which implies apoptosis, and NFκB was decreased in a dose-dependent manner. DNA fragmentation was seen in the treatment groups as compared to the control group using gel electrophoresis. Identification and quantification of compounds were carried out by GC-MS and HPLC, resp.; 2(5H)furanone with IC50 of 1.99 ± 0.01 μg/mL could be the responsible anticancer compound In conclusion, these findings suggest the potential use of the crude extract of G. applanatum as a natural source with anticancer activity against cervical cancer. In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Visualization of Pathway Usage in an Extended Carbohydrate Conversion Network Reveals the Impact of Solvent-Enabled Proton Transfer》 was written by Jensen, Pernille R.; Knudsen, Rikke K.; Meier, Sebastian. SDS of cas: 19444-84-9 And the article was included in ACS Sustainable Chemistry & Engineering on August 17 ,2020. The article conveys some information:

Bio-sourced mols. should increasingly contribute to meeting societal demands for energy and chems., while reducing net carbon dioxide release and the dependence on fossil resources. Especially oxygenated chems. can be derived from carbohydrates, and the conversion of carbohydrates in protic and nonprotic solvents has attracted considerable interest. Here, we probe chemocatalytic carbohydrate conversion in a time-resolved manner using quant. in situ NMR spectroscopy. A core reaction network in the carbohydrate conversion by Sn(IV) in nonprotic solvents is followed by identifying and quant. tracking 10 chems. with more than 70 at. sites. In situ anal. yields nine rate constants and shows that (co)solvents with labile protons strongly affect tautomerization kinetics and product distributions at an upstream branch point of the reaction network. Solvent-enabled tautomerization and the ensuing accumulation of reactive 1,2-dicarbonyl compounds can thus be key factors influencing reaction kinetics and atom economy in carbohydrate conversion. A reaction network for carbohydrate valorization was observed, revealing the impact of solvent protons on the desired process and on aggregation and degradation reactions. In the experimental materials used by the author, we found 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9SDS of cas: 19444-84-9)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.SDS of cas: 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Safety of 3-Hydroxydihydrofuran-2(3H)-oneOn September 30, 2021 ,《Antidiabetic and antilipidemic effect of Clerodendrum paniculatum flower ethanolic extract. An in vivo investigation in Albino Wistar rats》 was published in Biocatalysis and Agricultural Biotechnology. The article was written by Varghese, Sincy; Kannappan, Poornima; Kanakasabapathi, Devaki; Madathil, SriRashmy; Perumalsamy, Muneeswari. The article contains the following contents:

The goal was to evaluate the effects of ethanolic extract of Clerodendrum paniculatum flower (CPF) on antidiabetic and antilipidemic tests indexes of exptl.-induced hyperglycemic rats. High Fat Diet (HFD) treated Streptozotocin (STZ) induced diabetic rats were used for this study. The acute toxicity of ethanolic extract of C. paniculatum flower (2000 mg/kg body weight) and antidiabetic effect of CPF (200 mg/kg body weight)were studied in rats. Glibenclamide (1.25 mg/kg body weight) was used as a reference drug. For antihyperglycemic evaluation, glucose, C-peptide, Insulin, Hb and glycosylated Hb(HbA1c) levels were analyzed. Low d. lipoprotein (LDL), High d. lipoprotein(HDL), triglycerides and total cholesterol were analyzed in rats. The enzymic antioxidant activity (super oxide dismutase(SOD), glutathione peroxidase(GPx), glutathione S transferase (GST) and Catalase) and non-enzymic antioxidant activity(vitamin C, vitamin E and reduced glutathione) of C. Paniculatum flower were evaluated. Important carbohydrate metabolizing enzymes like Glucose 6-phosphatase, Fructose 1and 6 diphosphatase and hexokinase were determined in exptl. rats. After the oral administration of CPF extract significantly reduced glucose levels and cholesterol values. Extract improved enzymic and non enzymic antioxidant levels. CPF extract is useful in controlling blood glucose level as well as improving lipid metabolism and body weight in rats with induced diabetic rats. The results came from multiple reactions, including the reaction of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Safety of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Safety of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Groenewold, Gary S.; Hodges, Brittany; Hoover, Amber N.; Li, Chenlin; Zarzana, Christopher A.; Rigg, Kyle; Ray, Allison E. published an article on February 3 ,2020. The article was titled 《Signatures of Biologically Driven Hemicellulose Modification Quantified by Analytical Pyrolysis Coupled with Multidimensional Gas Chromatography Mass Spectrometry》, and you may find the article in ACS Sustainable Chemistry & Engineering.Related Products of 19444-84-9 The information in the text is summarized as follows:

Biomass storage conditions are a major source of feedstock quality variability that impact downstream preprocessing, feeding, handling and conversion into biofuels, chems. and products. Microbial activity in the stored biomass can result in heating that can modify or degrade the cell walls of the biomass, changing its characteristics. Anal. pyrolysis has been used to characterize biomass, but at temperatures typically used (∼600°C), differentiation of samples having different storage histories is subtle or non-existent. In this study, lower-temperature (400°C) pyrolysis was used to show large differences in corn stover samples that had experienced different biol. heating histories, indicated by pyrolysis products that were identified, and in several cases quantified using two-dimensional gas chromatog. / mass spectrometry. Pyrolysis of the samples originating from biomass that had experienced biol. heating during storage generated small oxygenates such as furfural, 5-Me furfural and 2-(5H)-furanone with efficiencies that were as much as ten times greater than those measured for samples that were not significantly heated. Most of the pyrolysis products with enhanced efficiencies were C5 oxygenates, suggesting formation from hemicellulosic precursor polymers in the corn stover. The findings suggest that biol. heating is disrupting the cell wall structure, fragmenting the hemicellulose or cellulose chains, and generating more polymer termini that have higher efficiency for generating the oxygenates at lower temperatures Further, anal. pyrolysis conducted at lower temperatures may be a beneficial strategy for improved biomass cell wall characterization, and for providing insights to understand and manage the feedstock variability to inform harvest and storage best management practices. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Related Products of 19444-84-9)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Related Products of 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Xuepeng; Liu, Yanwei; Wang, YuanYuan; Wang, Jinxiang; Xu, Yongxia; Yi, Shumin; Zhu, Wenhui; Mi, Hongbo; Li, Tingting; Li, Jianrong published an article on January 31 ,2021. The article was titled 《Combined ultrasound and heat pretreatment improve the enzymatic hydrolysis of clam (Aloididae aloidi) and the flavor of hydrolysates》, and you may find the article in Innovative Food Science & Emerging Technologies.Electric Literature of C4H6O3 The information in the text is summarized as follows:

The effects of pretreatments with ultrasound (UP), heat (HP), and combinations of heat-ultrasound (HP-UP) and ultrasound-heat (UP-HP) on the flesh enzymolysis of clam (Aloididae aloidi) and the flavor characteristics of hydrolyzates were investigated. The optimum UP pretreatment conditions for the hydrolysis were obtained at ultrasound power of 500 W, ultrasound time of 20 min, and liquid/solid (L/S) ratio of 2:1 (v/w), yielded 41.33% of hydrolysis degree (DH). Among the different pretreatments, the UP pretreatment had the highest DH value, while the HP-UP pretreatment obtained the highest soluble peptide content. The UP pretreatment efficiently enhanced the contents of taste-active components, including free amino acids, 5′-nucleotides, and succinic acid. The HP pretreatment promoted the formation of pleasant volatile compounds and reduced the content of unpleasant volatile compounds, such as 1-octen-3-ol and 2-ethyl-1-hexanol. The combined HP-UP pretreatment was an effective method for improving the enzymic hydrolysis of clam and the flavor of hydrolyzate. In the experiment, the researchers used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Electric Literature of C4H6O3)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Electric Literature of C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 696-59-3In 2021 ,《Synthesis and Characterization of New S-substituted Sulfanylpyridines, 3-Aminothieno[2,3-b] Pyridines and 3-(1H-pyrrol-1-yl) Thieno[2,3-b] Pyridines and Related Heterocycles》 was published in Journal of Chemical and Pharmaceutical Research. The article was written by Bakhite, Etify. The article contains the following contents:

Reaction of Et (3-cyano-5-ethoxycarbonyl-6-methyl-4-styryl-2-pyridylsulfanyl)acetate with hydrazine hydrate gave a mixture of the corresponding (3-cyano-5-ethoxycarbonyl-6-methyl-4-styryl-2-pyridylsulfanyl)acetohydrazide and di-Et 3-amino-6-methyl-4-styrylthieno[2,3-b]pyridine-2,5-dicarboxylate. The latter compound was reacted with 2,5-dimethoxytetrahydrofuran to give 3-(1H-pyrrol-1-yl)thieno[2,3-b]pyridine. Partial hydrazinolysis resulted in the formation of 5-ethoxycarbonyl-6-methyl-3-(1H-pyrrol-1-yl)-4-styrylthieno[2,3-b]pyridine-2-carbohydrazide. The (3-cyano-5-ethoxycarbonyl-6-methyl-4-styryl-2-pyridylsulfanyl)acetohydrazide and 5-ethoxycarbonyl-6-methyl-3-(1H-pyrrol-1-yl)-4-styrylthieno[2,3-b]pyridine-2-carbohydrazide were used as precursors for the title compounds, e.g., I by subjecting them to some sequential reactions with different reagents. All new compounds were characterized on the basis of their elemental analyses and spectroscopic data. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Product Details of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Product Details of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 19444-84-9On November 27, 2019 ,《Lignin Conversion Using Catalytic Ionic Liquids: Understanding the Role of Cations, Anions, and Hammett Acidity Functions》 appeared in Industrial & Engineering Chemistry Research. The author of the article were Singh, Sandip K.; Dhepe, Paresh L.. The article conveys some information:

Because it is undisputable that lignin depolymerization is a must to make the biorefinery concept economically feasible, several efforts are put toward it; however, a lot of catalyst designing is required to achieve efficient depolymerization activities. In this work, we show a systematic approach in the synthesis and characterization of ionic liquids (ILs) with varying combinations of cations (imidazole, benzimidazole, phosphonium, and ammonium) and anions (HSO4, PTS (p-toluenesulfonate), Cl, H2PO4, SnCl3, FeCl4, and CuCl3) for the depolymerization of lignin into low-mol. weight aromatic fractions (<220 g/mol) under mild reaction conditions (120 °C, 1 h, ambient pressure). In a methodical approach, effects of various reaction parameters such as temperature (70-170 °C), time (15-360 min), pressure (N2, 0.5-3 MPa), solvents and substrate, and so forth were studied to achieve best activity. Among all the catalysts, IL with the imidazolium cation and HSO4 as the anion showed best activity (78% yield). Subsequent to depolymerization, three aromatic monomers (5 wt % pure vanillin) were isolated using flash column chromatog. These aromatic monomers were characterized using gas chromatog. (GC), GC-mass spectrometry, and NMR techniques for their purity. Hammett acidity functions (H0) of ILs were measured using UV-vis photo-spectroscopy, and values are correlated with lignin depolymerization results. Lignin and tetrahydrofuran-soluble products were thoroughly characterized using assorted physicochem. techniques such as NMR (1H and 13C), gel permittivity chromatog., thermogravimetric anal., and so forth. The catalyst was recycled up to six runs and showed similar results in consecutive reactions. In the experimental materials used by the author, we found 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Related Products of 19444-84-9)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Related Products of 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Formula: C4H6O3On October 31, 2020 ,《Advantages of using ohmic heating in Dulce de Leche manufacturing》 appeared in Innovative Food Science & Emerging Technologies. The author of the article were Silva, Ramon; Rocha, Ramon S.; Guimaraes, Jonas T.; Balthazar, Celso F.; Pimentel, Tatiana C.; Neto, Roberto P. C.; Tavares, Maria Ines B.; Esmerino, Erick A.; Duarte, Maria Carmela K. H.; Freitas, Monica Q.; Silva, Paulo Henrique F.; Cappato, Leandro P.; Raices, Renata S. L.; Silva, Marcia C.; Cruz, Adriano G.. The article conveys some information:

Ohmic heating (OH, 0, 2, 4, 6, 8, or 10 V cm-1, 72 °C/15 s, 60 Hz) at Dulce de leche processing was investigated. The equipment consisted in an ohmic heating chamber, and rectangular 316 stainless steel electrodes positioned 10 cm apart. OH-treated milk resulted in improvements in the quality parameters of Dulce de leche, with a decrease in energy expenditure (69.85-141.86 vs 1260 kJ) and hydroxymethylfurfural (HMF) levels (7.64-8.54 vs 9.53 μmol L-1), an increase in product homogeneity, and formation of volatile compounds important for the sweetness of Dulce de leche (butanoic acid and 2-furan methanol). In addition, the physicochem. composition, fatty acid profile, and health indexes (atherogenic, thrombogenic, desired fatty acids, and hypercholesterolemic saturated fatty acids) of the products remained without changes. In particular, the use of higher elec. field (> 6 V cm-1) led to a 14-78% decrease in process time, and improved volatiles profile. OH has proven to be a suitable technol. for milk treatment, resulting in improvements in the quality parameters of Dulce de leche with pos. impact at the process time and energy expenditure. The Dulce de Leche processing is characterized by long cooking times to acquire its typical characteristic color and flavor. Normally, it is used pasteurized milk as raw material. Ohmic heating decreased the total time of processing in Dulce de leche manufacturing, providing an economy at the in the energy costs without significant change at the quality parameters of the final product.3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Formula: C4H6O3) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Formula: C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem