Month: October 2022

Chen, Jianzhong; Zhang, Zhenfeng; Li, Bowen; Li, Feilong; Wang, Yulin; Zhao, Min; Gridnev, Ilya D.; Imamoto, Tsuneo; Zhang, Wanbin published the artcile< Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is tosylamine preparation enantioselective; tosylimine preparation hydrogenation palladium catalyst.

An efficient palladium acetate (an inexpensive Pd salt with low toxicity) catalyzed asym. hydrogenation of sterically hindered N-tosylimines RC(R1)=NS(O)2R2 (R = t-Bu, 1-methoxycyclohexyl, adamantan-1-yl, etc.; R1 = Ph, 2H-1,3-benzodioxol-5-yl, Me, etc.; R2 = Ph, Me, 4-FC6H4, etc.), (E)-N-(2,2-Dimethylcyclopentylidene)-4-methylbenzenesulfonamide and (E)-4-Methyl-N-(2,2,5,5-tetramethyldihydrofuran-3(2H)-ylidene)benzenesulfonamide is realized with high catalytic activities (S/C up to 5000) and excellent enantioselectivities (ee up to 99.9%). Quantum chem. calculations suggest that uniformly high enantioselectivities are observed due to the structurally different S- and R-reaction pathways.

Nature Communications published new progress about Amines, chiral Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (tosyl). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhang, Lin; Badea, Beth Ann; Enyeart, Debra; Berger, Elaine M.; Mais, Dale E.; Boehm, Marcus F. published the artcile< Synthesis of isotopically labeled 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl]benzoic acid (LGD1069), a potent retinoid X receptor-selective Ligand>, Reference of 5455-94-7, the main research area is isotopically labeled retinoid preparation binding receptor; benzoic acid naphthylethenyl preparation binding receptor; naphthylethenylbenzoic acid preparation binding receptor.

LGD1069, 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl]benzoic acid, is the first retinoid X receptor (RXR)-selective retinoid to enter clin. trials for treatment of dermatol. diseases and cancer. In order to exam. biol. properties such as receptor binding, metabolism and bioavailability, [13C]-, [14C]-, and [3H]-labeled LGD1069 is required. Herein, the authors describe synthetic methods for preparing isotopically labeled homologs of LGD1069 and [3H]-9-cis-retinoic acid with RXR active retinoids. The final radiolabeled products, [6,7-3H]-LGD1069 and 3-[14C]-LGD1069 have specific activities of 56 Ci/mmol and 49 mCi/mmol, resp. Radiochem. purities are 99.5% for [6,7-3H]-LGD1069 and 99.0% for 3-[14C]-LGD1069. The chem. purity is 99.0% for 3-[13CD3]-LGD1069. Competition binding studies with known retinoids show similar Kd values when either [6,7-32H]-LGD1069 or [3H]-9-cis-retinoic acid as the radioligand.

Journal of Labelled Compounds & Radiopharmaceuticals published new progress about Receptors Role: BSU (Biological Study, Unclassified), BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Reference of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Yongxing; Lu, Yaowei; Cao, Qiue; Fang, Wenhao published the artcile< A magnetic CoRu-CoOX nanocomposite efficiently hydrogenates furfural to furfuryl alcohol at ambient H2 pressure in water>, Computed Properties of 97-99-4, the main research area is ruthenium cobalt oxide magnetic nanocomposite hydrogenation catalyst; hydrogenation catalyst furfural furfuryl alc.

A one-pot synthesized CoRu-CoOX nanocomposite was reported as a magnetically recoverable catalyst for selective hydrogenation of furfural to furfuryl alc. in water at ambient H2 pressure.

Chemical Communications (Cambridge, United Kingdom) published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Computed Properties of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Herrera, C.; Fuentealba, D.; Ghampson, I. T.; Sepulveda, C.; Garcia-Fierro, J. L.; Canales, Roberto I.; Escalona, N. published the artcile< Selective conversion of biomass-derived furfural to cyclopentanone over carbon nanotube-supported Ni catalyst in Pickering emulsions>, Related Products of 97-99-4, the main research area is furfural hydrogenation cyclopentanone carbon nanotube nickel catalyst Pickering emulsion.

A well-characterized carbon nanotube-supported nickel catalyst (Ni/CNTox) was assembled at the liquid-liquid interface and evaluated for the conversion of furfural. The nanoparticles were found to be mainly distributed on the interface of the emulsion droplets, forming stable Pickering emulsion. Catalytic activity was studied under different reaction conditions to determine an optimal condition for the rearrangement of furfural to cyclopentanone, an important precursor to valuable chems. It was found that the highest furfural conversion (35%) and cyclopentanone yield (25%) was obtained at 200 oC, 2 MPa of H2 pressure, and with the same dodecane/water ratio after 1 h of reaction.

Catalysis Communications published new progress about Carbon nanotubes (catalyst support). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Garavagno, Maria de los A.; Hernandez, Federico J.; Jara-Toro, Rafael A.; Mahecha, Genesys; Barrera, Javier A.; Taccone, Raul A.; Pino, Gustavo A. published the artcile< Rate coefficient and mechanism of the OH-initiated degradation of cyclobutanol: A combined experimental and theoretical study>, Related Products of 97-99-4, the main research area is cyclobutanol OH initiated degradation rate coefficient exptl theor study.

The degradation process of cyclobutanol (cButOH) by hydroxyl radical (OH), under atm. conditions, (750 ± 10) Torr of air and (296 ± 2) K, has been studied. The rate coefficient for the title reaction (k296K = (7.3 ± 0.6) x 10-12 cm3 mol.-1 s-1) was determined at 296 K by the conventional relative-rate method. Electronic structure calculations with uCCSD(T)/uBHandHLYP/aug-cc-PVDZ were conducted to study the reaction mechanism. The global rate coefficient was also calculated using the transition state theory with tunneling corrections, obtaining a value of 5.4 x 10-12 cm3 mol.-1 s-1 in agreement with the exptl. determination Addnl., reaction products identification in clean and NOx-contaminated atmospheres was performed for the first time. The identified reaction products and their corresponding yields (YP) depend on the environment composition in which the reaction is studied. In the absence of NOx, cyclobutanone (cButanone) was the only identified product, with YcButanone = (0.66 ± 0.08). In NOx-contaminated atmospheres, in addition to cButanone, THF (THF), 2-nitro-1-butanol (2N1B), 3-nitro-2-butanol (3N2B) and 2-methyl-2-nitro-1-propanol (2M2N1P), were also identified as primary reaction products. Under this condition, we were able to determine only the yields of cButanone and THF (YcButanone = 0.38 ± 0.05 and YTHF = 0.28 ± 0.02). A likely reaction mechanism for the observed products is proposed and the atm. implications are discussed.

Atmospheric Environment published new progress about Alcohols, nitro Role: POL (Pollutant), OCCU (Occurrence). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Nardelli, Silvia; Riggio, Oliviero; Rosati, Davide; Gioia, Stefania; Farcomeni, Alessio; Ridola, Lorenzo published the artcile< Hepatitis C virus eradication with directly acting antivirals improves health-related quality of life and psychological symptoms.>, Computed Properties of 58-97-9, the main research area is Alexithymia; Depression; Directly acting antivirals; Health related quality of life; Hepatitis C virus; State and trait anxiety.

BACKGROUND: Alterations in health-related quality of life (HRQoL) and neuropsychological disorders were described in the hepatitis C virus (HCV) patients. Although several studies investigated the modifications of HRQoL after HCV eradication, no data exists on the modifications of neuropsychological symptoms. AIM: To investigate the effect of directly acting antivirals (DAAs) treatment on HRQoL and neuropsychological symptoms. METHODS: Thirty nine patients with HCV infection underwent a neuropsychological assessment, including Zung-Self Depression-Rating-Scale, Spielberg State-Trait Anxiety Inventory Y1-Y2 and the Toronto-Alexithymia Scale-20 items before and after DAAs treatment. HRQoL was detected by Short-Form-36 (SF-36). RESULTS: All HRQoL domains, but role limitation physical and bodily pain, significantly improved after treatment. Interestingly, after DAAs treatment, all domains of HRQoL returned similar to those of controls. Each neuropsychological test significantly improved after HCV eradication. A significant correlation was observed among each psychological test and the summary components of SF-36. At multiple linear regression analysis including each psychological test as possible covariates, Zung-Self Depression Rating Scale (Zung-SDS) score was independently and significantly related to summary components of the SF-36 in the basal state and the difference between Zung-SDS score before and after treatment was the only variable significantly and independently related to the modification of HRQoL induced by the treatment. CONCLUSION: Neuropsychological symptoms strongly influenced HRQoL in HCV patients and there was a significant improvement of neuropsychological tests and HRQoL after DAAs treatment.

World journal of gastroenterology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Computed Properties of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Verevkin, Sergey P.; Siewert, Riko; Pimerzin, Andrey A. published the artcile< Furfuryl alcohol as a potential liquid organic hydrogen carrier (LOHC): Thermochemical and computational study>, HPLC of Formula: 97-99-4, the main research area is furfuryl alc liquid organic hydrogen carrier thermochem hydrogenation dehydrogenation.

The liquid organic H carriers (LOHCs) are considered as a promising materials for H storage. The liquid phase standard molar enthalpies of formation of furfuryl alc. and tetrahydrofurfuryl alc. were obtained from high-precision combustion calorimetry. Their standard molar enthalpies of vaporization were derived from the vapor pressure temperature dependences measured by the transpiration method. Gas phase molar enthalpies of formation of furfuryl alc. and tetrahydrofurfuryl alc. calculated by the high-level quantum-chem. method G4, were in an excellent agreement with the exptl. results. Reaction enthalpies and equilibrium temperature of the hydrogenation/dehydrogenation reactions of furfuryl alc. were calculated and compared with the data for furan and other potential liquid organic H carriers.

Fuel published new progress about Alcohols Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, HPLC of Formula: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Harrison, Carrie-Ann; Jackson, P. Mark; Moody, Christopher J.; Williams, Jonathan M. J. published the artcile< Cyclopenta[b]indoles. Part 2. Model studies towards the tremorgenic mycotoxins>, Reference of 5455-94-7, the main research area is cyclopentaindole; tremorgenic mycotoxin cyclopentindole.

The 7-bromocyclopenta[b]indole I has been converted into the hydroxybutenyl derivatives and a tetrahydrofuranylidene derivative in model studies towards the elaboration of paspalitrem and lolitrem type side chains. In a parallel approach, the cyclopentapyrrole II was converted into the fused α-pyrone III which acted as a pyrrole-2,3-quinodimethane, and underwent Diels-Alder reaction to give, after loss of carbon dioxide, the cyclopentaindoles, e.g. IV.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Indole alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Reference of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ryu, Incheol; Kim, Yoon Ki published the artcile< AU-rich element-mediated mRNA decay via the butyrate response factor 1 controls cellular levels of polyadenylated replication-dependent histone mRNAs>, Formula: C9H13N2O9P, the main research area is mRNA decay AU rich element BRF1 polyadenylated replication histone; ARE-mediated mRNA decay; ELAV like RNA binding protein 1 (ELAVL1); Hu antigen R (HuR); RNA; RNA degradation; RNA metabolism; RNA turnover; RNA-protein interaction; ZFP36 ring finger protein like 1 (ZFP36L1); butyrate response factor 1 (BRF1); histone mRNA biogenesis; mRNA stability; polyadenylation; posttranscriptional regulation; replication-dependent histone mRNA.

Replication-dependent histone (RDH) mRNAs have a nonpolyadenylated 3′-UTR that ends in a highly conserved stem-loop structure. Nonetheless, a subset of RDH mRNAs has a poly(A) tail under physiol. conditions. The biol. meaning of poly(A)-containing (+) RDH mRNAs and details of their biosynthesis remain elusive. Here, using HeLa cells and Western blotting, qRT-PCR, and biotinylated RNA pulldown assays, we show that poly(A)+ RDH mRNAs are post-transcriptionally regulated via adenylate- and uridylate-rich element-mediated mRNA decay (AMD). We observed that the rapid degradation of poly(A)+ RDH mRNA is driven by butyrate response factor 1 (BRF1; also known as ZFP36 ring finger protein-like 1) under normal conditions. Conversely, cellular stresses such as UV C irradiation promoted BRF1 degradation, increased the association of Hu antigen R (HuR; also known as ELAV-like RNA-binding protein 1) with the 3′-UTR of poly(A)+ RDH mRNAs, and eventually stabilized the poly(A)+ RDH mRNAs. Collectively, our results provide evidence that AMD surveils poly(A)+ RDH mRNAs via BRF1-mediated degradation under physiol. conditions.

Journal of Biological Chemistry published new progress about 3′-Untranslated region Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Formula: C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Falcao, Fatima; Lopes, Carla; Viegas, Erica; Perez, Rita; Aldir, Isabel; Farinha, Helena; Carvalho, Antonio; Mirco, Ana; Marques, Susana; Costa, Tiago Bana E.; Miranda, Ana Claudia; Lebre, Luis; Peixe, Paula; Chagas, Cristina; Mansinho, Kamal; Correia, Jose Manuel published the artcile< Experience of a Portuguese center: effectiveness of direct-acting antiviral therapy for hepatitis C>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is Antiviral Agents/therapeutic use; Hepacivirus/drug effects; Hepatitis C/drug therapy; Portugal.

Introduction: In late 2014, Portugal implemented a national program for the treatment of patients with chronic hepatitis C with directacting antiviral agents. This program has made Portugal one of the first European countries to implement a structured measure of treatment to eliminate this serious public health problem. The aim of this study was to assess the effectiveness of direct-acting antiviral therapy in the treatment of patients with chronic hepatitis C virus infection. Material and Methods: A retrospective observational study was conducted at Centro Hospitalar de Lisboa Ocidental on the national online platform from Dec. 2014 until Feb. 2017 and included patients with hepatitis C virus infection who underwent treatment. The primary endpoint was sustained virol. response at least 12 wk post treatment. Data was analyzed with the SPSS 17.0 program. Results: During the study period, 820 patients completed therapy and achieved sufficient follow-up time to assess sustained virol. response with an overall response rate of 97.2% (n = 797) and a response rate of 98.0%, 99.5%, 90.9%, 95.1% and 94.2% for genotypes 1a, 1b, 2, 3 and 4, resp. Data suggested that advanced fibrosis (F3/F4), human immunodeficiency virus co-infection and treatment failure with interferon and ribavirin were not neg. related with sustained virol. response in our population. Most patients (80.1%) completed treatment with ledipasvir/sofosbuvir ± ribavirin. The most common adverse events were fatigue and insomnia followed by headache and weight loss. Discussion: Patients predominantly had genotype 1 infection which correlates with HCV distribution in Europe, but we found a major proportion in genotype 4 which can be explained by immigration from African countries. Our patients’ ages ranging from 22 to 90 years, reflected a new approach with no upper age limit. Direct-acting antivirals regimens resulted in remarkably high SVR rates compared to interferon-based regimens, which were consistent with clin. trials data. Conclusion: Our data showed that direct-acting antiviral-based regimens are safe and have a high success rate in the treatment of patients with hepatitis C virus infection in a real-world setting.

Acta Medica Portuguesa published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem