Month: October 2022

Matsagar, Babasaheb M.; Hsu, Chang-Yen; Chen, Season S.; Ahamad, Tansir; Alshehri, Saad M.; Tsang, Daniel C. W.; Wu, Kevin C.-W. published the artcile< Selective hydrogenation of furfural to tetrahydrofurfuryl alcohol over a Rh-loaded carbon catalyst in aqueous solution under mild conditions>, SDS of cas: 97-99-4, the main research area is rhodium carbon catalyst furfural hydrogenation tetrahydrofurfuryl alc aqueous solution.

We describe the selective hydrogenation of furfural (FAL) into tetrahydrofurfuryl alc. (THFA) under mild conditions (30°C) in aqueous media using an Rh-loaded carbon (Rh/C) catalyst in a one-pot fashion. In FAL hydrogenation, the Rh/C catalyst showed a high THFA yield (92%) with 93% selectivity in aqueous media within 12 h, whereas the use of a dimethylacetamide (DMA) solvent system resulted in a 95% THFA yield within 32 h at 30°C. The study of the effect of the solvent on FAL hydrogenation reveals that polar solvents showed higher THFA yields than a toluene solvent. The Rh/C catalyst used in this study exhibited higher activity compared to Ru/C, Pd/C, Ni/C derived from Ni-based metal-organic framework (Ni-MOF), and Ni-loaded carbon black (Ni/CB) catalysts in FAL-to-THFA hydrogenation. The Rh/C catalyst is characterized in detail using various characterization techniques such as TEM, XRD, N2-adsorption-desorption, XPS, and ICP-OES to understand its physicochem. properties. The Rh/C catalyst shows similar high THFA yields in the recycling experiment of FAL hydrogenation under ambient conditions.

Sustainable Energy & Fuels published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, SDS of cas: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Smejkal, Tomas; Gopalsamuthiram, Vijayagopal; Ghorai, Sujit K.; Jawalekar, Anup M.; Pagar, Dinesh; Sawant, Krishna; Subramanian, Srinivas; Dallimore, Jonathan; Willetts, Nigel; Scutt, James N.; Whalley, Louisa; Hotson, Matthew; Hogan, Anne-Marie; Hodges, George published the artcile< Optimization of Manganese Coupling Reaction for Kilogram-Scale Preparation of Two Aryl-1,3-dione Building Blocks>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is manganese catalysis coupling reaction aryl dione building block preparation.

Aryl-1,3-diones represent a promising new class of herbicidal acetyl-CoA carboxylase (ACCase) inhibitors. The original synthesis of this structural motif employed in the research phase involved a selenium oxide mediated oxidation, the use of diazoacetate and aryl lead reagents, and a low temperature oxidation of an aryl lithium intermediate, so it was not well suited to large scale synthesis. For kilogram scale synthesis of the two aryl-1,3-dione building blocks I [R = Me, Et], we developed an alternative route which employs a manganese or manganese-copper catalyzed alkyl Grignard coupling and a semi-pinacol rearrangement of an epoxide as the key steps. The optimized conditions could be of general interest as scalable methods for the synthesis of 2-alkyl substituted benzaldehydes and of 2-aryl-1,3-diones.

Organic Process Research & Development published new progress about Coupling reaction. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sanchez, Vladimir; Salagre, Pilar; Gonzalez, Maria Dolores; Llorca, Jordi; Cesteros, Yolanda published the artcile< Effect of the formation of NiCu alloy and use of biomass-derived furfural on the catalytic hydrogenation of furfural to THFA>, Product Details of C5H10O2, the main research area is tetrahydrofurfuryl alc furfural nickel copper alloy catalytic hydrogenation biomass.

Several Ni, Cu and Ni-Cu catalysts supported on mesoporous hectorite were prepared, characterized and tested for the hydrogenation of com. furfural to obtain tetrahydrofurfuryl alc. (THFA). The highest selectivity to THFA (95%) for a total conversion was achieved with the Ni-Cu catalyst prepared with a Ni:Cu molar ratio of 1:1 after 4 h of reaction. This can be explained by the formation of NiCu alloy in high amounts for this sample (88%), as detected by XRD. The lower selectivity to THFA obtained with other bimetallic catalysts prepared with Ni:Cu molar ratios of 6:1 and 1:6 were attributed to the lower percentage of NiCu alloy together with the lowest Ni richness of the NiCu alloy. Addnl., the best catalyst resulted in a yield to THFA of 90%, in the toluene phase, and 80% in the aqueous neutralized phase, when using a biomass extract of furfural obtained from almond shells instead of com. furfural. After several reuses of the catalyst employed in the toluene phase, some decrease of THFA was observed due to the increase of the crystallite size of the Cu phase, as observed by XRD, that should decorate the active NiCu alloy particles.

Molecular Catalysis published new progress about Biomass. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yang, Youdi; Wang, Yanyan; Li, Shaopeng; Shen, Xiaojun; Chen, Bingfeng; Liu, Huizhen; Han, Buxing published the artcile< Selective hydrogenation of aromatic furfurals into aliphatic tetrahydrofurfural derivatives>, Name: (Tetrahydrofuran-2-yl)methanol, the main research area is furfural hydrogenation tetrahydrofurfural synthesis layered double hydroxide palladium catalyst.

Tetrahydrofurfural (THFF) and 5-hydroxymethyltetrahydro-2-furaldehyde (5-HMTHFF) are important chems. Synthesis of THFF and 5-HMTHFF from the selective hydrogenation of furfural (FF) and 5-hydroxymethylfurfural (HMF) is highly desirable. However, it is a great challenge to hydrogenate furanyl rings while keeping C=O intact. Herein, we found that Pd/LDH-MgAl-NO3 could efficiently catalyze the hydrogenation of FF to THFF and HMF to 5-HMTHFF in water. At near complete conversion of FF and HMF, the selectivities of THFF and 5-HMTHFF could reach 92.6% and 83.7%, resp. A series of control experiments showed that both the LDH-MgAl-NO3 support and water solvent played an important role in the unusual performance of the catalytic system. The hydrogenation of the furanyl ring occurred on the surface of Pd. Water prohibited the hydrogenation of the C=O group, and the special nature of LDH-MgAl-NO3 prevented hydrogenation of the C=O group on the support by the hydrogen spillover. Thus, the furanyl ring was selectively hydrogenated, and high selectivity of the desired product was successfully achieved. As far as we know, efficient hydrogenation of FF to THFF or HMF to 5-HMTHFF has not been reported. This work opens the way to selectively hydrogenate the furanyl ring while keeping C=O in the same mol. unchanged.

Green Chemistry published new progress about Green chemistry. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Name: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Takemasa, Chiaki; Chino, Teppei; Ishige, Ryohei; Ando, Shinji published the artcile< Anisotropic photoconductivity of aromatic and semi-aliphatic polyimide films: Effects of charge transfer, molecular orientation, and polymer chain packing>, Related Products of 4415-87-6, the main research area is polyimide film aromatic polymer chain packing mol orientation photoconductivity.

The anisotropic photoconductive properties of polyimide (PI) films prepared using seven types of dianhydrides and a diamine containing a diphenyl-benzidine structure featuring rigid linear structure and strong electron-donating ability were analyzed. Photoirradiation wavelength dependences of the in-plane and out-of-plane photocurrents, which are known as anisotropic photocurrent spectra, were investigated in comparison with optical absorption spectra, the degrees of mol. aggregation, in-plane/out-of-plane orientation of PI chains, and ordered structures formed in film state. We have previously reported that intermol. charge transfer (CT) interaction is a key factor for increasing the out-of-plane photoconductivity of PI films because they determine the efficiency of charge separation However, when sufficient charge carriers are generated in thin PI films via photo irradiation, in which penetration depth of irradiated light is sufficiently larger than the film thickness, suppression of charge recombination by reducing mol. chain packing is rather effective at enhancing both the in-plane and out-of-plane photoconductivity This is because the mobility of carriers is significantly increased in the dense aggregation structures, and thus collisions between carriers becomes more frequent, which led to higher recombination efficiency. Furthermore, the photocurrent anisotropy was increased as the degree of in-plane orientation of the main PI chains increased, which agrees with the fact that charged carriers are preferentially transported between PI chains. Accordingly, promoting charge transport efficiency by reducing PI chain packing and increasing the out-of-plane orientation of PI chains are essential to increase the in-plane photoconductivity of PI films.

Polymer published new progress about Molecular orientation. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Related Products of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Modelska, Magdalena; Binczarski, Michal J.; Kaminski, Zbigniew; Karski, Stanislaw; Kolesinska, Beata; Mierczynski, Pawel; Severino, Courtney J.; Stanishevsky, Andrei; Witonska, Izabela A. published the artcile< Bimetallic Pd-Au/SiO2 catalysts for reduction of furfural in water>, Application In Synthesis of 97-99-4, the main research area is palladium gold silicon dioxide furfural water bimetallic catalyst reduction.

Catalytic systems based on bimetallic Pd-Au particles deposited on SiO2 were prepared by ultrasonically assisted water impregnation and used in the hydrogenation of furfural obtained by the acidic hydrolysis of waste biomass (brewery’s spent grain) in aqueous phase. Pd-Au/SiO2 catalysts containing 50 g of Pd and 2-100 g of Au per 1 kg of catalyst were characterized by high activity in the studied process and, depending on the Pd/Au ratio, selectivity to 2-methyloxolan-2-ol. The modification of 5%Pd/SiO2 by Au leads to the formation of dispersed Au-Pd solid solution phases, which was confirmed by XRD, XPS, ToF-SIMS, SEM-EDS, and H2-TPR techniques. The effect of dilution of surface palladium by gold atoms is probably crucial for modification of the reaction mechanism and formation of 2-methyloxolan-2-ol as the main product.

Catalysts published new progress about Acid hydrolysis. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application In Synthesis of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Fouad, Hanan M.; Sabry, Magda A.; Ahmed, Amal; Hassany, Mohamed; Al Soda, Mohamed F.; Abdel Aziz, Hossam published the artcile< Generic ledipasvir-sofosbuvir treatment for adolescents with chronic hepatitis C virus infection>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is Egypt; HCV; adolescents; brand; generic ledipasvir-sofosbuvir.

We assessed the safety and efficacy of a generic form of ledipasvir-sofosbuvir for the treatment of hepatitis C virus infection in Egyptian adolescents and compared the results with those of treatment with the brand-named form. The generic form resulted in a high response rate, significant improvement in liver function, and mild adverse effects. These results are comparable with those of the brand form at a reduced price.

Journal of the Pediatric Infectious Diseases Society published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Mai, Anh Thi Minh; Thakur, Ashutosh; Ton, Nhan Nu Thanh; Nguyen, Thanh Nhat; Kaneko, Tatsuo; Taniike, Toshiaki published the artcile< Photodegradation of a semi-aromatic bio-derived polyimide>, Formula: C8H4O6, the main research area is semi aromatic polyimide photodegradation mech property.

Recently, we have developed a thermoelec. superior and highly transparent bio-derived polyimide using microorganism-derived 4-aminocinnamic acid. Here, the stability of the novel bio-derived polyimide under photoirradiation was systematically investigated. IR spectroscopy (IR), solid-state NMR, and tensile tests were employed for studying the impacts of the irradiation on both chem. and mech. properties of the material. The structural modifications of the material were analyzed in the form of spectral expression of correlation coefficients It was found that the bio-derived polyimide maintained its stability well up to several hundreds of hours. Elongated radiation caused deterioration at the imide ring and the tertiary carbon of the cyclobutane ring, accompanied by the growth of carbonyl species as an oxidation product.

Polymer Degradation and Stability published new progress about Elongation at break. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Formula: C8H4O6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Galkina, Olesia S.; Maas, Gerhard; Rodina, Liudmila L.; Nikolaev, Valerij A. published the artcile< Eco-Friendly Approach to Tetrasubstituted Diazodihydrofuranones: Valuable Precursors of Oxetane Derivatives and Other Heterocyclic Compounds>, COA of Formula: C8H14O2, the main research area is diazodihydrofuranone tetrasubstituted green preparation crystal structure.

Eco-friendly routes to 2,2,5,5-tetrasubstituted 4-diazodihydrofuran-3(2H)-ones were developed. In this manner, useful precursors to oxetane derivatives, potential NSAIDs, and other biol. active pharmaceuticals can be prepared without use of toxic reagents and solvents.

Synthesis published new progress about Crystal structure. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, COA of Formula: C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Carmen Lafita-Navarro, M.; Perez-Castro, Lizbeth; Zacharias, Lauren G.; Barnes, Spencer; DeBerardinis, Ralph J.; Conacci-Sorrell, Maralice published the artcile< The transcription factors aryl hydrocarbon receptor and MYC cooperate in the regulation of cellular metabolism>, Quality Control of 58-97-9, the main research area is fibroblast cellular metabolism transcription factors aryl hydrocarbon receptor MYC; MYC (c-Myc); aryl hydrocarbon receptor (AHR); cancer; gene regulation; glioblastoma; glycolysis; metabolism; metabolomics; oncogene; pyrimidine.

The transcription factor AHR (aryl hydrocarbon receptor) drives the expression of genes involved in detoxification pathways in cells exposed to pollutants and other small mols. Moreover, AHR supports transcriptional programs that promote ribosome biogenesis and protein synthesis in cells stimulated to proliferate by the oncoprotein MYC. Thus, AHR is necessary for the proliferation of MYC-overexpressing cells. To define metabolic pathways in which AHR cooperates with MYC in supporting cell growth, here we used LC-MS-based metabolomics to examine the metabolome of MYC-expressing cells upon AHR knockdown. We found that AHR knockdown reduced lactate, S-lactoylglutathione, N-acetyl-L-alanine, 2-hydroxyglutarate, and UMP levels. Using our previously obtained RNA sequencing data, we found that AHR mediates the expression of the UMP-generating enzymes dihydroorotate dehydrogenase (quinone) (DHODH) and uridine monophosphate synthetase (UMPS), as well as lactate dehydrogenase A (LDHA), establishing a mechanism by which AHR regulates lactate and UMP production in MYC-overexpressing cells. AHR knockdown in glioblastoma cells also reduced the expression of LDHA (and lactate), DHODH, and UMPS but did not affect UMP levels, likely because of compensatory mechanisms in these cells. Our results indicate that AHR contributes to the regulation of metabolic pathways necessary for the proliferation of transformed cells.

Journal of Biological Chemistry published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (ALDOA). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Quality Control of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem