October 2022 | Page 31 of 55 | Heterocyclic Building Blocks-Tetrahydrofuran

Rohit, Kizhakkekuttu Radhakrishnan’s team published research in Journal of Heterocyclic Chemistry in 2022 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Related Products of 696-59-3

Related Products of 696-59-3In 2022 ,《A solvent-free manganese(II) -catalyzed Clauson-Kaas protocol for the synthesis of N-aryl pyrroles under microwave irradiation》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Rohit, Kizhakkekuttu Radhakrishnan; Meera, Gopinadh; Anilkumar, Gopinathan. The article conveys some information:

The first manganese-catalyzed modified Clauson-Kaas reaction for N-substituted pyrroles I (R = Ph, 2-bromo-4-methylphenyl, 1,3-benzothiazol-2-yl, etc.) synthesis using 2,5-dimethoxytetrahydrofuran with variously substituted aromatic amines RNH2 has been developed (up to 89% yield). This interesting neat strategy is free from additives including co-catalysts, ligands, and acids. Relatively low cost, environmentally benign, and handy Mn(NO3)2.4H2O is employed as the catalyst under microwave conditions with a very short reaction time (20 min). The above qualities attest to the green nature of this reaction. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Related Products of 696-59-3)

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Karuppiah, Vijayakumar’s team published research in World Journal of Microbiology & Biotechnology in 2021 | CAS: 19444-84-9

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Name: 3-Hydroxydihydrofuran-2(3H)-one

《Anti-quorum sensing and antibiofilm potential of 1,8-cineole derived from Musa paradisiaca against Pseudomonas aeruginosa strain PAO1》 was written by Karuppiah, Vijayakumar; Thirunanasambandham, Ramanathan; Thangaraj, Gunasekaran. Name: 3-Hydroxydihydrofuran-2(3H)-one And the article was included in World Journal of Microbiology & Biotechnology on April 30 ,2021. The article conveys some information:

Abstract: Pseudomonas aeruginosa is one of the vulnerable opportunistic pathogens associated with nosocomial infections, cystic fibrosis, burn wounds and surgical site infections. Several studies have reported that quorum sensing (QS) systems are controlled the P. aeruginosa pathogenicity. Hence, the targeting of QS considered as an alternative approach to control P. aeruginosa infections. This study aimed to evaluate the anti-quorum sensing and antibiofilm inhibitory potential of Musa paradisiaca against Chromobacterium violaceum (ATCC 12472) and Pseudomonas aeruginosa. The methanol extract of M. paradisiacsa exhibits that better antibiofilm potential against P. aeruginosa. Then, the crude methanol extract was subjected to purify by column chromatog. and collected the fractions. The mass-spectrometric anal. of a methanol extract of M. paradisiaca revealed that 1,8-cineole is the major compounds 1, 8-cineole significantly inhibited the QS regulated violacein production in C. violaceum. Moreover, 1,8-cineole significantly inhibited the QS mediated virulence production and biofilm formation of P. aeruginosa without affecting their growth. The real-time PCR anal. showed the downregulation of autoinducer synthase and transcriptional regulator genes upon 1,8-cineole treatment. The findings of the present study strongly suggested that metabolite of M. paradisiaca impedes P. aeruginosa QS system and associated virulence productions. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Name: 3-Hydroxydihydrofuran-2(3H)-one)

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Stanko, Oleg V.’s team published research in Phosphorus, Sulfur and Silicon and the Related Elements in 2019 | CAS: 696-59-3

The author of 《Fluorinated iminophosphonates bearing stereodirecting phenylethyl group in synthesis of biorelevant scalemic aminophosphonates》 were Stanko, Oleg V.; Rassukana, Yuliya V.; Onys’ko, Petro P.. And the article was published in Phosphorus, Sulfur and Silicon and the Related Elements in 2019. Electric Literature of C6H12O3 The author mentioned the following in the article:

Diastereoselective reduction of α-(poly)fluoroalkylated iminophosphonates, bearing stereodirecting phenylethyl group at the nitrogen atom, produces diastereomeric N-(α-phenylethyl) polyfluoroalkylphosphonates. Separation and N-deprotection affords (S) and (R) α-amino polyfluoroalkylphosphonates. The latter react with 2,5-dimethoxytetrahydrofuran to give optically pure polyfluoroalkylphosphonates incorporating 1-pyrrolyl group in α-position. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Electric Literature of C6H12O3)

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Miao, Dandan’s team published research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2019 | CAS: 696-59-3

The author of 《Photochemical synthesis of π-extended ullazine derivatives as new electron donors for efficient conjugated D-A polymers》 were Miao, Dandan; Aumaitre, Cyril; Morin, Jean-Francois. And the article was published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2019. Quality Control of 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

We report the synthesis of π-extended ullazine derivatives annulated with either electron-poor pyridine or electron-rich thiophene units through a metal-free, photochem. cyclodehydrochlorination (CDHC) reaction. The strongest electron-donor derivative, 7-tetradecylthieno[3′,2′:7,8]indolizino[6,5,4,3-ija]thieno[2,3-c]quinolone, was copolymerized with electron-deficient thienopyrroledione (TPD), isoindigo (IID), and diketopyrrolopyrrole (DPP) derivatives to provide three donor-acceptor conjugated polymers (D-A CPs). Their photophys., electrochem. and photovoltaic (PV) properties were investigated. The polymers showed broad UV-vis-NIR absorption bands with λmax values of 612 nm, 698 nm, 788 nm in chloroform and exhibited optical bandgap (Eoptg) of 1.58 eV, 1.41 eV, 1.24 eV measured as films. Inverted bulk heterojunction polymer solar cells (BHJ-PSCs) were fabricated using these polymers as host and light-harvesting materials. The device based on P3:PC70BM blends shows the best power conversion efficiency (PCE) of 2.23% (Voc = 0.55 V, Jsc = 7.86 mA cm-2, FF = 52%). These promising results demonstrate that π-extended ullazine derivatives can be used as electron-rich building blocks for the construction of D-A CPs for efficient PSCs applications. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran)

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Polina, I. N.’s team published research in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2022 | CAS: 19444-84-9

Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-oneOn May 31, 2022, Polina, I. N.; Mironov, M. V.; Belyy, V. A.; Brovarova, O. V. published an article in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya. The article was 《Investigation of the component composition of the oxidative thermal degradation products of fuel pellets from the Heracleum sosnowskyi Manden biomass by chromatography-mass-spectrometry》. The article mentions the following:

The component composition of oxidative thermal degradation products of Heracleum sosnowskyi Manden biomass was studied by chromatog.-mass-spectrometry. The hogweed Sosnovskyi biomass was collected on the territory of the village of Vylgort in the Komi Republic, dried to an atm.-dry state, crushed to dm < 0.25 mm and pressed with a force of 10 kN. Fuel pellets were burned in the special device. The products of oxidative thermal degradation were captured and analyzed on a gas-liquid chromatog. with a mass-selective detector. As a result of mass spectrums anal., 39 low-mol.-weight products with a retention time of 6 to 79 min and a percentage content of 0.4 to 12% were identified from 47 captured compounds Qual. and quant. anal. of the component composition of the degradation products showed that their formation is directly related to the component composition of the biomass and is determined by the content of cellulose, hemicellulose and lignin. Anal. of data on retention time of the degradation products showed that cellulose and hemicellulose of the biomass sample are degraded priority, while lignin is thermally more stable due to its aromatic nature. Anal. of data on products of oxidative thermal degradation showed that in mass terms, polysaccharides and lignin are formed as a percentage 45 and 49 resp., while the composition of the products of destruction of polysaccharides is more diverse (23 and 16 names). It is shown that the list of products of oxidative thermal degradation of the Heracleum sosnowskyi Manden biomass is comparable to the products of thermal decomposition of lignocellulosic materials of other botanical origin. The results of the presented study can be used in the calculation of processes and installations for burning fuel pellets from the biomass of the Heracleum sosnowskyi Manden or a combined composition fuel pellets. As well as the results can be used to assess the complex environmental impact of the technol. of the energy use of the biomass of the hogweed Sosnowskyi on the atm. air. After reading the article, we found that the author used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one)

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

El-Khayat, Hesham’s team published research in European Journal of Gastroenterology & Hepatology in 2019 | 58-97-9

European Journal of Gastroenterology & Hepatology published new progress about Chronic hepatitis. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, HPLC of Formula: 58-97-9.

El-Khayat, Hesham; Kamal, Enas M.; Yakoot, Mostafa; Gawad, Manal A.; Kamal, Naglaa; El Shabrawi, Mortada; Sameh, Yehia; Haseeb, Alaa; Fouad, Yasser; Attia, Dina published the artcile< Effectiveness of 8-week sofosbuvir/ledipasvir in the adolescent chronic hepatitis C-infected patients>, HPLC of Formula: 58-97-9, the main research area is chronic hepatitis effectiveness genotype human.

The sustained virol. response (SVR) rate for the 12-wk sofosbuvir (SOF)/ledipasvir (LVD) treatment of adolescent genotype-4 patients is high. The aim of this study is to evaluate 8 vs. 12-wk treatment efficacy and safety in adolescent genotype-4 patients. In total, 157 chronic hepatitis C-infected adolescent patients (mean age 14±2 years, 62% males) were included in this study. All patients received a morning dose of SOF (400 mg)/LVD (90 mg) as a single tablet for 8 and 12 wk. Laboratory and biochem. monitoring were performed at weeks 4 and 8, end of treatment (8/12) and 12 wk after the end of treatment (SVR12). In total, SVR12 was 98% [95% confidence interval (CI): 96-100] for all treated patients. For patients treated for 12 wk, SVR12 was 97.6% (95% CI: 96-101) (82/84 patients), and 98.6% (95% CI: 93-101) (72/73) patients for those treated for 8 wk. For both regimens, no serious adverse effects, treatment discontinuation or cases of death were detected. The main adverse effects for the 8-wk patient group were fatigue (2.8%), headache (1.4%), nausea (1.4%) and epigastric tenderness (1.4%). For the 12-wk-treated group, adverse events were epigastric tenderness (1.2%), nausea (1.2%), diarrhoea (2.4%) and rash (2.4%). Three patients were lost to follow-up: two were in the 12-wk treatment group and one was in the 8-wk group. All of them reached end of treatment but were lost before SVR12. No relapsers were observed in either group. Eight weeks of treatment of SOF/LVD combination is equally effective and safe as 12 wk in adolescent genotype-4 patients.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Qiao, Du’s team published research in Cellular and molecular biology (Noisy-le-Grand, France) in 2022-02-04 | 58-97-9

Cellular and molecular biology (Noisy-le-Grand, France) published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Qiao, Du; Cheng, Luo; Xiaomei, Tian; Baolei, Shi; Yingyi, Li; Hui, Zhang; Shaohua, Bian; Wei, Liu; U, Dai Y; Fangqiong, Deng; Jie, Liu; Shuangning, Liu published the artcile< Effect of ultra-mini percutaneous nephrolithotomy and ShuoTong ureteroscopy on the stress response, inflammatory indices, and urokinase level in patients with polycystic kidney disease complicated with renal calculus.>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is .

This study aimed to explore the effects of ultra-mini percutaneous nephrolithotomy (UMP) combined with ShuoTong ureteroscopy on the stress response, inflammation indicators and urokinase levels in patients with polycystic kidney disease and kidney stones. In this study, 42 patients with polycystic kidney disease and kidney stones diagnosed and treated in our hospital from February 2018 to February 2021 were selected as the research objects. They were randomly divided into the control group and the study group, with 21 cases in each group, and the control group adopted Ultra-mini percutaneous nephrolithotomy treatment; the study group was combined with ShuoTong ureteroscopy on the basis of the control group, and compared and analyzed the stress response, inflammation indexes, urokinase level, renal function, complications and stone clearance rate of the two groups of patients. After treatment, the average operation time, channel establishment time, hemoglobin decline, number of puncture channels, and hospital stay in the study group were significantly shorter than those in the control group (P<0.05); after treatment, the reduction in CRP and PCT in the study group was significantly higher than that in the control group The increase of Ang I and Ang II in the control group was significantly lower than that in the control group (P<0.05); the improvement of PGE2, NO, and LPO levels in the study group was significantly higher than that in the control group after treatment (P<0.05); the study group TH, Cys- The levels of C and β2-MG were significantly lower than those of the control group; the UK levels of the study group were significantly lower than those of the control group (P<0.05); the complication rate of 14.29% in the study group after treatment was significantly lower than that of the control group 33.33%; the study group The stone clearance rate of 95.24% was significantly higher than that of the control group 80.95% (P<0.05). In general, UMP combined with ShuoTong ureteroscopy is used to treat polycystic kidney with kidney stones, accurately determine the tip position of the needle sheath, ensure that the needle sheath enters the collection system to adjust its position, reduce patient stress and inflammation, improve safety and feasibility, and is worthy of clinical practice Promote applications. Cellular and molecular biology (Noisy-le-Grand, France) published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Tian, Hongli’s team published research in Molecular Catalysis in 2021-06-30 | 97-99-4

Molecular Catalysis published new progress about Agglomeration. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, SDS of cas: 97-99-4.

Tian, Hongli; Gao, Guoming; Xu, Qing; Gao, Zhiran; Zhang, Shu; Hu, Guangzhi; Xu, Leilei; Hu, Xun published the artcile< Facilitating selective conversion of furfural to cyclopentanone via reducing availability of metallic nickel sites>, SDS of cas: 97-99-4, the main research area is furfural cyclopentanone hydrogenation nickel catalyst.

Conversion of the biomass-derived furfural to cyclopentanone (CPO) involves multiple hydrogenation steps, in which not only the type but also the abundance of metallic sites might impact fates of the reaction intermediates and consequently selectivity of the products. In this study, we found that, during the hydrogenation, the carbonyl and the furan ring functionalities in furfural showed the different response to the number of nickel sites on Ni/SiO2 catalyst. The hydrogenation of the C = O in furfural could take place effectively with the nickel loading below 1 wt% to form firstly furfuryl alc. (FA) and then to CPO with the selectivity as high as 98.2%. In comparison, the higher nickel loading favored the hydrogenation of the furan ring in furfural or FA to form tetrahydrofurfuryl alc. (THFA), formation of which eliminated the chance for the formation of CPO. The hydrogenation of the carbonyl functionality and furan ring in furfural proceeded via distinct orientations of adsorption and the involvement of the varied number of metal sites. Controlling the number of exposed metallic nickel sites could thus tailor the selectivity of the products in hydrogenation of furfural.

Molecular Catalysis published new progress about Agglomeration. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, SDS of cas: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Papadopoulos, Giorgos N’s team published research in ChemSusChem in 2020-11-15 | 97-99-4

ChemSusChem published new progress about C-H bond activation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Reference of 97-99-4.

Papadopoulos, Giorgos N.; Kokotou, Maroula G.; Spiliopoulou, Nikoleta; Nikitas, Nikolaos F.; Voutyritsa, Errika; Tzaras, Dimitrios I.; Kaplaneris, Nikolaos; Kokotos, Christoforos G. published the artcile< Phenylglyoxylic Acid: An Efficient Initiator for the Photochemical Hydrogen Atom Transfer C-H Functionalization of Heterocycles>, Reference of 97-99-4, the main research area is heterocycle green preparation phenylglyoxylic acid catalyst hydrogen atom transfer; C−H activation; hydrogen atom transfer; metal-free processes; phenylglyoxylic acid; photochemistry.

A cheap and efficient photochem. method was developed for the C-H functionalization of heterocycles was studied. Phenylglyoxylic acid (PhCOCOOH) would behave as an alternative to metal-based catalysts and organic dyes and provided a very general and wide array of photochem. C-H alkylation, alkenylation, and alkynylation, as well as C-N bond forming reaction methodologies. This novel, mild, and metal-free protocol was successfully employed in the functionalization of a wide range of C-H bonds, utilized not only O- or N-heterocycles, but also the less studied S-heterocycles.

ChemSusChem published new progress about C-H bond activation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Reference of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lin, Chia-Ching’s team published research in Nature Communications in 2021-12-31 | 58-97-9

Nature Communications published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (Tut4). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Lin, Chia-Ching; Shen, Yi-Ru; Chang, Chi-Chih; Guo, Xiang-Yi; Young, Yun-Yun; Lai, Ting-Yu; Yu, I-Shing; Lee, Chih-Yuan; Chuang, Tsung-Hsien; Tsai, Hsin-Yue; Hsu, Li-Chung published the artcile< Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation>, Product Details of C9H13N2O9P, the main research area is terminal uridyltransferase 7 TLR4 regenase1 uridylation inflammation.

Different levels of regulatory mechanisms, including posttranscriptional regulation, are needed to elaborately regulate inflammatory responses to prevent harmful effects. Terminal uridyltransferase 7 (TUT7) controls RNA stability by adding uridines to its 3 ends, but its function in innate immune response remains obscure. Here we reveal that TLR4 activation induces TUT7, which in turn selectively regulates the production of a subset of cytokines, including Interleukin 6 (IL-6). TUT7 regulates IL-6 expression by controlling RNase Regnase-1 mRNA (encoded by Zc3h12a gene) stability. Mechanistically, TLR4 activation causes TUT7 to bind directly to the stem-loop structure on Zc3h12a 3-UTR, thereby promotes Zc3h12a uridylation and degradation Zc3h12a from LPS-treated TUT7-sufficient macrophages possesses increased oligo-uridylated ends with shorter poly(A) tails, whereas oligo-uridylated Zc3h12a is significantly reduced in Tut7-/- cells after TLR4 activation. Together, our findings reveal the functional role of TUT7 in sculpting TLR4-driven responses by modulating mRNA stability of a selected set of inflammatory mediators.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem