Month: October 2022

Hsu, Shih-Jer; Enkhzaya, Sukhee; Lin, You-Yu; Tseng, Tai-Chung; Khosbayar, Tulgaa; Tsai, Cheng-Hsueh; Wang, Tzu-San; Enkhtuya, Damba; Ivshinkhorol, Dogsom; Naranzul, Nyamsuren; Jargalsaikhan, Badarch; Amarsanaa, Jazag; Baatarkhuu, Oidov; Kao, Jia-Horng published the artcile< Resistance-associated substitution and ledipasvir/sofosbuvir therapy in Mongolian chronic hepatitis C patients>, Synthetic Route of 58-97-9, the main research area is chronic hepatitis C ledipasvir sofosbuvir NS5A Mongolia; Chronic hepatitis C; Ledipasvir; Mongolia; Resistance-associated substitution; Sofosbuvir.

We investigated the effectiveness of ledipasvir/sofosbuvir and the impact of resistance-associated substitutions on the treatment outcome in Mongolian chronic hepatitis C patients. Patients with genotype (GT) 1b HCV infection were prospectively enrolled in Mongolia and treated with LDV/SOF for 12 wk. The proportion of pre-treatment NS5A Y93H RAS in viral quasispecies was measured with next-generation sequencing. The endpoint of LDV/SOF effectiveness was sustained virol. response at post-treatment week 12 (SVR12). A total of 94 CHC patients were evaluated. The baseline Y93H proportion was <1% in 74 patients, 1-15% in 7, 15-50% in 2, and ≥50% in 11. All patients completed 12-wk LDV/SOF treatment and the SVR rate was 90.4%. The rate of failure to achieve SVR12 for patients with Y93H < 1%, 1-15%, and ≥15% were 0%, 14.3%, and 61.5%, resp. (p for trend = 0.001). In univariable anal., older age, baseline alanine transaminase level <40 U/mL, and a higher proportion of Y93H were associated with treatment failure. In multivariable anal., only a higher proportion of Y93H was associated with treatment failure (p = 0.022). LDV/SOF therapy achieves a high SVR rate in Mongolian CHC GT1b patients without baseline Y93H RAS. A higher proportion of Y93H may severely undermine the effectiveness of LDV/SOF. Journal of the Formosan Medical Association published new progress about Aging, animal. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Synthetic Route of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Saimoto, Hiroyuki; Hiyama, Tamejiro; Nozaki, Hitosi published the artcile< Regiocontrolled formation of 4,5-dihydro-3(2H)-furanones from 2-butyne-1,4-diol derivatives. Synthesis of bullatenone and geiparvarin>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is furanone dihydro; butynediol cyclization; bullatenone; geiparvarin.

Two new methods for selective hydration of 1,1,4-trisubstituted 2-butyne-1,4-diols (I) gave 4,5-dihydro-3(2H)-furanones. The first involves selective monoacetylation of the less hindered OH followed by Ag(I)-catalyzed rearrangement and cyclization. to give 3-acetoxy-2,2,5-trisubstituted 2,5-dihydrofurans (II) which on hydrolysis gave 2,2,5-trisubstituted 4,5-dihydro-3(2H)-furanones. Oxidation of II with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone gave 3(2H)-furanones. This method gave naturally occurring 3(2H)-furanones, e.g., bullatenone and geiparvarin. The second approach gave the opposite regioisomer, 2,5,5-trisubstituted 4,5-dihydro-3(2H)-furanones, from diols I by treating the diols with Hg/Nafion-H.

Bulletin of the Chemical Society of Japan published new progress about Cyclization. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brister, Matthew M.; Crespo-Hernandez, Carlos E. published the artcile< Excited-State Dynamics in the RNA Nucleotide Uridine 5'-Monophosphate Investigated Using Femtosecond Broadband Transient Absorption Spectroscopy>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is RNA UMP excited state dynamics electronic relaxation absorption spectroscopy.

Damage to RNA from UV radiation induces chem. modifications to the nucleobases. Unraveling the excited states involved in these reactions is essential; however, investigations aimed at understanding the electronic-energy relaxation pathways of the RNA nucleotide UMP have not received enough attention. In this Letter, the excited-state dynamics of UMP is investigated in aqueous solution Excitation at 267 nm results in a trifurcation event that leads to the simultaneous population of the vibrationally excited ground state, a long-lived 1nπ* state, and a receiver triplet state within 200 fs. The receiver state internally converts to the long-lived 3ππ* state in an ultrafast time scale. The results elucidate the electronic relaxation pathways and clarify earlier transient absorption experiments performed for uracil derivatives in solution This mechanistic information is important because long-lived nπ* and ππ* excited states of both singlet and triplet multiplicities are thought to lead to the formation of harmful photoproducts.

Journal of Physical Chemistry Letters published new progress about Excited singlet state. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wasacz, J. P.; Badding, V. G. published the artcile< A hydration of an alkyne illustrating steam and vacuum distillation>, HPLC of Formula: 5455-94-7, the main research area is laboratory experiment alkyne hydration; steam distillation laboratory experiment.

An experiment involving the conversion of 2,5-dimethyl-3-hexyne-2,5-diol to 2,2,5,5-tetramethyltetrahydrofuran-3-one, suitable for an early organic chem. laboratory course and using aqueous mercuric sulfate without the use of acid, is described. The experiment demonstrated several principles and techniques: hydration of an alkyne; steam distillation; vacuum distillation (optimal); drying of an organic liquid; stereochem.; synthesis of a ketone; keto-enol tautomerism; synthesis of a cyclic ether; and salting out techniques (optional).

Journal of Chemical Education published new progress about Alkynes Role: MSC (Miscellaneous). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, HPLC of Formula: 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ren, Dezhang; Wang, Jingyi; Jiang, Xuelei; Song, Zhiyuan; Norinaga, Koyo; Huo, Zhibao published the artcile< A Supported Ni Catalyst Produced from Ni-Al Hydrotalcite-Like Precursor for Reduction of Furfuryl Alcohol to Tetrahydrofurfuryl Alcohol by NaBH4 in Water>, Synthetic Route of 97-99-4, the main research area is furfuryl alc reduction nickel catalyst preparation property.

Tetrahydrofurfuryl alc. (THFA) is a kind of high value-added compound in industry, which can be obtained from biomass chem. engineering. However, Synthesis of THFA under mild condition with green hydrogen donors remains a big challenge. In this article, a supported Ni catalyst derived from Ni-Al hydrotalcite-like compounds (HTs) as precursors for the reduction of furfuryl alc. (FA) into THFA with NaBH4 as reducing agent in water was first reported. As a result, Ni/Al2O3-HT exhibited high catalytic activity for the transformation, and THFA was achieved in 100% yield at 60°C for 60 min. Moreover, Ni/Al2O3-HT could be recycled at least seven times without the loss of its activity. Under optimized conditions, the reduction reaction of several furan and ketone compounds was investigated. A possible mechanism for the reduction of FA to afford THFA was also proposed.

ChemistrySelect published new progress about Pore size (volume). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Synthetic Route of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lu, Yunhua; Zhang, Jianhua; Xiao, Guoyong; Li, Lin; Hou, Mengjie; Hu, Junyi; Wang, Tonghua published the artcile< Synthesis and gas permeation properties of thermally rearranged poly(ether-benzoxazole)s with low rearrangement temperatures>, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is polyetherbenzoxazole synthesis thermal rearrangement gas permeation property.

The diamine monomer, 9,9-bis[4-(4-amino-3-hydroxylphenoxy)phenyl] fluorene (bis-AHPPF) was successfully synthesized according to our modified method. A series of hydroxyl-containing poly(ether-imide)s (HPEIs) were prepared by polycondensation of the bis-AHPPF diamine with six kinds of dianhydrides, including 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), pyromellitic dianhydride (PMDA), 3,3′,4,4′-biphenyl tetracarboxylic diandhydride (BPDA), 3,3′,4,4′-oxydiphthalic anhydride (ODPA), 3,3′,4,4′-benzophenonetetracarboxylic dianhydride (BTDA) and 4,4′-(hexafluoroisopropylidine)diphthalic anhydride (6FDA) followed by thermal imidization. The corresponding thermally rearranged (TR) membranes were obtained by solid state thermal treatment at high temperature under a nitrogen atm. The chem. structure, and phys., thermal and mech. properties of the HPEI precursors were characterized. The effects of heat treatment temperature and dianhydrides on the gas transport properties of the poly(ether-benzoxazole) (PEBO) membranes were also investigated. It was found that these HPEIs showed excellent thermal and mech. properties. All the HPEI precursors underwent thermal conversion in a N2 atmosphere with low rearrangement temperatures The gas permeabilities of the PEBO membranes increased with the increase of thermal treatment temperature When HPEI-6FDA was treated at 450°C for 1 h, the H2, CO2, O2 and N2 permeabilities of the membrane reached 239.6, 196.04, 46.41 and 9.25 Barrers coupled with a O2/N2 selectivity of 5.02 and a CO2/N2 selectivity of 21.19. In six TR-PEBOs, PEBO-6FDA exhibited the lowest rearrangement temperature and largest gas permeabilities. Therefore, thermally rearranged membranes from bis-AHPPF-based HPEIs are expected to be promising materials for gas separation

RSC Advances published new progress about Complex modulus, tan δ. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ueno, Masaharu; Huang, Yi-Yong; Yamano, Akihito; Kobayashi, Shu published the artcile< Revised Stereochemistry of Ceramide-Trafficking Inhibitor HPA-12 by X-ray Crystallography Analysis>, COA of Formula: C9H15NO4, the main research area is crystal mol structure ceramide trafficking inhibitor HPA; ceramide trafficking inhibitor preparation MSBAR.

In response to Berkes’s report revising the stereochem. of HPA-12, an important ceramide-trafficking inhibitor that was discovered and synthesized and its stereochem. determined in 2001, the synthesis and the stereochem. were reinvestigated. A large-scale synthetic method for HPA-12 based on a Zn-catalyzed asym. Mannich-type reaction in water was developed. Single crystals of HPA-12 for X-ray crystallog. anal. were obtained from Et propionate/n-hexane, and the stereochem. was definitely determined to be 1R,3S, consistent with Berkes’s revised structure.

Organic Letters published new progress about Conformation. 137105-97-6 belongs to class tetrahydrofurans, and the molecular formula is C9H15NO4, COA of Formula: C9H15NO4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hu, Kaitai; Ye, Qingqing; Fan, Yingtao; Nan, Junyi; Chen, Fangyuan; Gao, Yang; Shen, Yingzhong published the artcile< Preparation and characterization of organic soluble polyimides with low dielectric constant containing trifluoromethyl for optoelectronic application>, Related Products of 4415-87-6, the main research area is organic polyimide dielec trifluoromethyl optoelectronic.

Polyimide (PI) films have excellent comprehensive properties and bright prospects in the next generation of optoelectronic and microelectronic applications. PIs were synthesized by aromatic diamines and alicyclic dianhydrides considered to be the most effective method for preparing polyimides with high light transmittance and low dielec. constant In order to improve the overall performance of polyimide, the introduction of a large trifluoromethyl group into the main chain is also considered a powerful strategy. In this article a novel diamine containing 6 trifluoromethyl groups has been designed and synthesized by Suzuki reaction. Afterwards, PIs were synthesized with fluorinated aromatic dianhydride and alicyclic dianhydride through a two-step method. The two PIs have excellent solubility: PI-a and PI-b exhibited excellent solubility in common polar solvents. Such as DMF, DMAc, NMP and DMSO at room temperature, and PI-a was soluble in low-boiling solvents such as Et acetate, CH2Cl2 and CHCl3 at room temperature PI-b was soluble in low-boiling solvents acetone and CHCl3 at room temperature, which was rarely seen in other aromatic polyimides. Soluble in common organic solvents, especially low b.p. solvents, made these polymers easy to process and suitable for processing technol. in solution This was an important modification for PIs. They also showed good high temperature resistance: the decomposition temperature (T5%) of two PIs were 520°C and 475°C. In addition, the residual rate at 790°C was 50% and 49% resp. Two PI films had a very low dielec. constant 2.26 and 2.24, resp., which was attributed to the hyperbranched structure and strong electron-withdrawing fluorine-containing groups. PI-a and PI-b also had low water absorption of 0.66% and 0.72%, resp. The transmittance of PI-a and PI-b high transparent films at 450 nm were 74% and 82%, resp. The significant optical modification was mainly due to the weak electron-accepting alicyclic unit and the large trifluoromethyl electron withdrawing group. This work mainly provided an effective strategy for synthesizing comprehensive excellent performance PIs with high transmittance, excellent solubility, low water absorption, high heat resistance and low dielec. constant

European Polymer Journal published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Related Products of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Pirmoradi, Maryam; Gulotty, Robert J.; Kastner, James R. published the artcile< Continuous hydroxyketone production from furfural using Pd-TiO2 supported on activated carbon>, Product Details of C5H10O2, the main research area is hydroxyketone furfural palladium titania activated carbon catalyst.

Pd-TiO2, Pd-Cu and Pd-Fe activated carbon (AC) supported catalysts were employed for continuous selective hydrogenation of furfural. The effect of reaction parameters on product selectivity and space time yield (STY) was determined Weak acid sites, generated by the Pd-TiO2 catalyst opened the furan ring and resulted in a STY of 134 g Lcat-1 h-1 (610 g kgcat-1 h-1) and 39% selectivity to 5-hydroxy-2-pentanone (5H2P), a hydrogenation product of furan ring opening, in a short residence time (7.6 min) at 180°C and 300 psig. The Pd-Cu and Pd-Fe catalysts were selective towards tetrahydrofurfuryl alc. and furfuryl alc. A STY of 259 g Lcat-1 h-1 (1182 g kgcat-1 h-1) and 42% selectivity to furfuryl alc. was achieved in the presence of the Pd-Cu catalyst at 180°C and 300 psig (3.8 min). The Pd/TiO2/AC catalyst shows promise for continuous production of 5H2P, a building block for many drugs and a precursor to 1,4-pentanediol.

Catalysis Science & Technology published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem