Month: October 2022

Vega, Ana D.; Hynicka, Lauren M.; Claeys, Kimberly; Chua, Joel V.; Heil, Emily L. published the artcile< Effectiveness of 8 weeks of ledipasvir/sofosbuvir for hepatitis C in HCV-HIV-coinfected patients>, Application In Synthesis of 58-97-9, the main research area is ledipasvir sofosbuvir antiviral agent hepatitis C virus HIV.

Background: Data is limited on the use of 8 wk of therapy with ledipasvir/sofosbuvir (LDV/SOF) for special populations such as HCV-HIV-coinfected patients. The primary objective of this anal. was to compare sustained virol. response at 12 wk after end of therapy (SVR12) rates among HCV-monoinfected and HCV-HIV-coinfected patients in a real-world clin. setting. Addnl., we compared SVR12 rates among patients receiving 8 vs. 12 wk of therapy. Methods: This was a single-center, retrospective study of HCV-infected patients prescribed LDV/SOF at ambulatory clinics associated with the University of Maryland Medical Center (UMMC) from May 2015 to May 2016. Data were obtained from UMMC electronic medical records and outpatient pharmacy claims database. Comparisons between groups were made using χ2 or Fisher’s exact test for categorical variables and Student’s t-test or Wilcoxon rank-sum for continuous variables. All analyses were per-protocol; patients missing SVR12 data (25.2%) could not be evaluated for our stated objectives. Results: A total of 274 patients were included. Median age was 58 years; 62.8% were male; 82.5% were Black. SVR12 data was available for 65 HCV-HIV-coinfected patients, of which 62 (95.4%) achieved SVR12. There was no difference in SVR12 rate between HCV-HIV-coinfected patients and HCV-monoinfected patients (86/90; 95.6%; P=0.959). Addnl., there was no difference in SVR12 attainment between HIV-HCV-coinfected patients who received 8 vs. 12 wk of therapy (P=0.101). Conclusions: 8 wk of LDV/SOF was effective for treatment-naive, non-cirrhotic, HCV genotype-1 patients in this real-world setting, regardless of HIV status. Increased uptake of the 8-wk regimen can decrease costs for patients and payers without compromising outcomes.

Antiviral Therapy published new progress about Antiviral agents. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application In Synthesis of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Nikul’shin, P. A.; Ershov, M. A.; Grigor’yeva, E. V.; Tarazanov, S. V.; Kuznetsova, S. N.; Repina, O. V. published the artcile< Furfural Derivatives as Fuel Components>, Formula: C5H10O2, the main research area is furfural derivative fuel component additive.

Furfural derivatives prepared from vegetable raw materials have recently become popular as high-performance fuel additives. Furfural oxygenates are particularly of interest. A lot of research was devoted to preparing new materials from furfural, however, there is much to be discovered about their effect on physicochem. properties of fuels. The possibility of using furfural derivatives, obtained by their hydrogenation on copper and nickel catalysts with full conversion of furfural, as additives to fuel is considered in this article. Their impact on antiknock properties and chem. stability is evaluated. Futons are mostly effective in low-octane hydrocarbon bases, such as hydrocracking gasoline, at a concentration of 5-30 weight %. A high concentration of potential resins can lead to the formation of deposits in the combustion chamber of the engine, which, in turn, requires addnl. research.

Chemistry and Technology of Fuels and Oils published new progress about Biomass hydrotreatment. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Elgohary, Mohamed Abdel-Salam; Hasan, Eman Medhat; Ibrahim, Amany Ahmad; Abdelsalam, Mohamed Farouk Ahmed; Abdel-Rahman, Raafat Zaher; Zaki, Ashraf Ibrahim; Elaatar, Mohamed Bakr; Elnagar, Mohamed Thabet; Emam, Mohamed Emam; Hamada, Mahmoud Moustafa; Abdel-Hamid, Taimour Mohamed; Abdel-Hafez, Ahmad Samir; Seadawy, Mohamed Gomaa; Fatoh, Ahmad Rashad; Elsaied, Mohamed Ali; Sakr, Marwa Abdel-Rahman; Elkady, Ahmed Omar; Shehata, Mohamed Muawad; Nawar, Osama Mohamed; Selem, Mohamed Abu-Elnaga; Abd-Aal, Mohamed Saeed; Lotfy, Hany Hafez; Elnagdy, Tarek Refaat; Helmy, Sherine; Mubark, Magdy Amin published the artcile< Efficacy of Sofosbuvir plus Ledipasvir in Egyptian patients with COVID-19 compared to standard treatment: a randomized controlled trial.>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is SARS-CoV-2 infection; effective curing; sofosbuvir/ledipasvir.

COVID-19 is a pandemic disease caused by SARS-CoV-2, which is an RNA virus similar to the hepatitis C virus (HCV) in the replication process. Sofosbuvir/ledipasvir is an approved drug to treat HCV infection. This study investigates the efficacy of Sofosbuvir/ledipasvir as a treatment for patients with moderate COVID-19 infection. This is a single-blinded parallel-randomized controlled trial. The participants were randomized equally into the intervention group that received Sofosbuvir/ledipasvir (S.L. group), and the control group received Oseltamivir, Hydroxychloroquine, and Azithromycin (OCH group). The primary outcomes were the cure rate over time and the incidence of serious adverse events. The secondary outcomes included the laboratory findings. 250 patients were divided equally into each group. Both groups were similar regarding gender, but age was higher in the S.L. group (p=0.001). In the S.L. group, 89 (71.2%) patients were cured, while only 51 (40.8%) patients were cured in the OCH group. The cure rate was significantly higher in the S.L. group (RR=1.75, p<0.001). Kaplan-Meir plot showed a considerably higher cure over time in the S.L. group (Log-rank test, p=0.032). There were no deaths in the S.L. group, but there were six deaths (4.8%) in the OCH group (RR=0.08, p=0.013). Seven patients (5.6%) in the S.L. group and six patients (4.8%) in the OCH group were admitted to the intensive care unit (ICU) (RR=1.17, P=0.776). There were no significant differences between treatment groups regarding total leukocyte and neutrophils count, lymph, and urea. Sofosbuvir/ledipasvir is suggestive of being effective in treating patients with moderate COVID-19 infection. Further studies are needed to compare Sofosbuvir/ledipasvir with new treatment protocols. Journal of medicine and life published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Guanya; Xie, Chunyan; Wang, Qinhua; Wan, Dan; Zhang, Yan; Wu, Xin; Yin, Yulong published the artcile< Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is pig epithelial cell uridine monophosphate metabolism.

Taken together, oral administration of UR and UMP could improve the small intestinal morphol., promote epithelial cell apoptosis and renewal of intestinal villus tips, and benefit intestinal development and health thus improving the growth performance and reducing the risk of diarrhea in early-weaned piglets. Moreover, UMP and UR increased the apoptosis ratio of intestinal epithelial cells in in vivo and in vitro experiments Both the UMP and UR decreased the expression of CAD and RRM2 at the jejunal mucosa. UR increased the jejunum villus length/crypt depth ratio, Claudin-3 and E-cadherin expression, and the pyrimidine nucleotide metabolic enzymes including CMPK1, RRM2, UPRT, CTPS1 and CTPS2 in the duodenal mucosa. Results showed that UMP and UR supplements improved the ADG of piglets, and decreased the diarrhea rate. Twenty-one piglets were randomly allotted into three groups, the control group, UMP group and UR group, and orally administered UMP or UR for 10 days. This study aims to investigate the functional effects of UMP and UR on the gut in vitro and in vivo. Uridine monophosphate (UMP) is a major nucleotide analog in mammalian milk and uridine (UR) is its gastro-intestinal metabolite in vivo.

Food & Function published new progress about Apoptosis. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Harper, Kaid C.; Vilardi, Sarah C.; Sigman, Matthew S. published the artcile< Prediction of Catalyst and Substrate Performance in the Enantioselective Propargylation of Aliphatic Ketones by a Multidimensional Model of Steric Effects>, Product Details of C8H14O2, the main research area is catalyst substrate performance enantioselective propargylation aliphatic ketone steric effect.

The effectiveness of a new asym. catalytic methodol. is often weighed by the number of diverse substrates that undergo reaction with high enantioselectivity. Here we report a study that correlates substrate and ligand steric effects to enantioselectivity for the propargylation of aliphatic ketones. The math. model is shown to be highly predictive when applied to substrate/catalyst combinations outside the training set.

Journal of the American Chemical Society published new progress about Aliphatic ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Product Details of C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Jun, Minki; Yang, Heesu; Kim, Dongyong; Bang, Gi Joo; Kim, Minah; Jin, Haneul; Kwon, Taehyun; Baik, Hionsuck; Sohn, Jeong-Hun; Jung, Yousung; Kim, Heejin; Lee, Kwangyeol published the artcile< Pd3Pb Nanosponges for Selective Conversion of Furfural to Furfuryl Alcohol under Mild Condition>, Category: tetrahydrofurans, the main research area is furfural furfuryl alc palladium lead nanosponge selective conversion; bimetallic alloys; furfural; hydrogenation; nanoframes; palladium.

Alloy structures with high catalytic surface areas and tunable surface energies can lead to high catalytic selectivity and activities. Herein, the synthesis of sponge-like Pd3Pb multiframes (Pd3Pb MFs) is reported by using the thermodynamically driven phase segregation, which exhibit high selectivity (93%) for the conversion of furfural to furfuryl alc. (FOL) under mild conditions. The excellent catalytic performance of the Pd3Pb MF catalysts is attributed to the high surface area and optimized surface energy of the catalyst, which is associated with the introduction of Pb to Pd. D. functional theory calculations show that the binding energy of FOL to the surface energy-tuned Pd3Pb MF is sufficiently lowered to prevent side reactions such as over-hydrogenation of FOL.

Small Methods published new progress about Acetalization. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ando, Wataru; Kumamoto, Yorio; Tokito, Norihiro published the artcile< Photolysis of a sterically protected bicyclic 1,2,3-selenadiazole>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is selenadiazole sterically protected photolysis olefin; regioselective photochem cyclocondensation selenadiazole olefin; zwitterionic intermediate photolysis selenadiazole.

The photolysis of sterically protected 1,2,3-selenadiazole I in the presence of olefin (e.g. CH2:CHCN, CH2:CHCO2Me, cyclopentadiene) was studied. The regioselective cycloadducts e.g. II (R = CO2Me, cyano) were obtained via the initially formed zwitterionic intermediate.

Tetrahedron Letters published new progress about Photocyclocondensation reaction. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

MacIntosh, Kathryn L.; Beaumont, Simon K. published the artcile< Nickel-Catalyzed Vapour-Phase Hydrogenation of Furfural, Insights into Reactivity and Deactivation>, Quality Control of 97-99-4, the main research area is nickel catalytic vapor phase hydrogenation furfural.

Furfural is a key bioderived platform mol., and its hydrogenation affords access to a number of important chem. intermediates that can act as drop-in replacements to those derived from crude oil or novel alternatives with desirable properties. Here, the vapor phase hydrogenation of furfural to furfuryl alc. at 180° over standard impregnated Ni catalysts is reported and contrasted with the same reaction over Cu chromite. While the selectivity to furfuryl alc. of the unmodified Ni catalysts is much lower than for Cu chromite as expected, the activity of the Ni catalysts in the vapor phase is significantly higher, and the deactivation profile remarkably similar. In the case of the supported Ni catalysts, possible contribution to the deactivation by acidic sites on the catalyst support is discounted based on the similarity of deactivation kinetics on Ni/SiO2 with those seen for less acidic Ni/TiO2 and Ni/CeO2. Powder x-ray diffraction is used to exclude sintering as a primary deactivation pathway. Significant coking of the catalyst (∼ 30% over 16 h) is observed using temperature programmed oxidation This, in combination with the solvent extraction anal. and IR spectroscopy of the coked catalysts points to deactivation by polymeric condensation products of (reactant or) products and hydrocarbon like coke. These findings pave the way for targeted modification of Ni catalysts to use for this important biofeedstock-to-chems. transformation.

Topics in Catalysis published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Quality Control of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yates, Peter; Burke, Patrick Michael published the artcile< Keto ethers. IV. Products formed on reaction of dihydro-2,2,5,5-tetramethyl-3(2H)-furanone with strong acids>, Synthetic Route of 5455-94-7, the main research area is tetramethylfuranone rearrangement acid; furanone tetramethyl rearrangement acid.

Reaction of furanone I with 96 or ca. 100% sulfuric acid or hot polyphosphoric acid followed by aqueous quenching gave the following products: 2-hydroxy-2,5-dimethyl-4-hexen-3-one, 2,4,4-trimethyl-2-cyclopenten-1-one, 3,5,5-trimethyl-2-cyclopenten-1-one, tetrahydro-3,4,5,5-tetramethylfuran-2,3-diol, 2,5-dihydro-3,5,5-trimethyl-2-methylenefuran and its dimer, 2,5-dihydro-2,3,5,5-tetramethyl-2-furanol, 4-hydroxy-2,4-dimethyl-2-pentenoic acid γ-lactone, 2,3,5-trimethyl-2-cyclopenten-1-one (II), and tetramethylfuran (III). In 96% sulfuric acid the products arise by ring opening, ring opening followed by reclosure to carbocyclic products, Me migration from C-2 to C-3 to give rearranged furan derivatives, and oxidation In ca. 100% sulfuric acid or hot polyphosphoric acid further Me migrations can occur to give II and III.

Canadian Journal of Chemistry published new progress about Rearrangement. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Synthetic Route of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Yanling; Liu, Cun; Zhang, Xiongfu published the artcile< One-Step Encapsulation of Bimetallic Pd-Co Nanoparticles Within UiO-66 for Selective Conversion of Furfural to Cyclopentanone>, Synthetic Route of 97-99-4, the main research area is bimetallic palladium cobalt furfural cyclopentanone nanoparticle.

The design of efficient catalysts is of important significance for the transformation of biomass into chems. In this work, bimetallic Pd-Co nanoparticles were encapsulated within UiO-66 to form a core-shell Pd-Co@UiO-66 catalyst via a facile one-step strategy. The as-synthesized Pd-Co@UiO-66 catalysts were characterized and applied to the selective hydrogenation of furfural (FUR) to cyclopentanone (CPO). Compared with the monometallic Pd@UiO-66, the Pd-Co@UiO-66 could demonstrate excellent performance with 96% CPO selectivity and 99% FUR conversion at 120°C under 3 MPa H2 pressure for 12 h. It was found that trace Co had synergetic and promoting effects on the catalytic performance. The core-shell catalysts showed more outstanding recyclability than the supported catalysts, which could maintain high CPO yield after 5th runs.

Catalysis Letters published new progress about Core-shell nanoparticles. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Synthetic Route of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem