《A synthetic protocol for (-)-ketorolac; development of asymmetric gold(I)-catalyzed cyclization of allyl alcohol with pyrrole ring core》 was written by Sasaki, Ikuo; Yamasaki, Naoto; Kasai, Yusuke; Imagawa, Hiroshi; Yamamoto, Hirofumi. Electric Literature of C6H12O3 And the article was included in Tetrahedron Letters in 2020. The article conveys some information:
An asym. synthesis of (-)- and (+)-ketorolac was achieved with 89% ee using a novel Friedel-Crafts (FC) type C-C bond forming cyclization of an allyl alc. containing a pyrrole ring core in the presence of a bimetallic gold(I) salt complex prepared from a 2:2:1 combination of AuCl·SMe2, AgOTf and chiral Quinaphos. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Electric Literature of C6H12O3)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Electric Literature of C6H12O3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem