Rahmatpour, Ali; Sajjadinezhad, Seyed Mehrzad; Mirkani, Ahmad; Notash, Behrouz published their research in Tetrahedron in 2021. The article was titled 《Regioselective synthesis of di-aromatic ring-fused 2,8-dioxa/dithia bicyclo[3.3.1]nonane derivatives via recyclable polymeric Bronsted acid-catalyzed one-pot tandem formation of multiple chemical C-C/C-O and C-C/C-S bonds》.Application of 696-59-3 The article contains the following contents:
An environmentally benign and straightforward synthetic approach for the assembly of a new class of diverse sym. substituted di-aromatic-fused 2,8-dioxa/dithiabicyclo[3.3.1]nonane derivatives containing methylene-bridged bicyclic framework via reusable cross-linked polystyrene-supported p-toluenesulfonic acid-catalyzed tandem reactions of substituted phenols/selected thiophenol with 1,1,3,3-tetramethoxypropane under neat conditions has been reported in which four new chem. bonds (two C-C/two C-O)-(two C-C/two C-S), two new six-membered cycles, and two new stereogenic tertiary carbon centers were constructed in a single operation. The synthetic utility of this method was also demonstrated. In addition, this present protocol could be successfully extended to the selected naphthols and dihydroxynaphthalenes as the enol partner of phenols with high efficiency. The developed transformation featured high efficiency, the use of com. accessible feedstocks, excellent regioselectivity, simple operation, gram-scale synthesis, and good functional group compatibility. Furthermore, the solvent-free conditions, easily recoverable catalyst, and efficient recycling render the protocol green, economic and sustainable. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application of 696-59-3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem