Day: October 19, 2022

HPLC of Formula: 696-59-3In 2021 ,《Synthesis, Characterization, and Crystal Structure of Some New Tetrahydroisoquinolines and Related Tetrahydrothieno[2,3-c]isoquinolines》 was published in ACS Omega. The article was written by Marae, Islam S.; Bakhite, Etify A.; Moustafa, Osama S.; Abbady, Mohamed S.; Mohamed, Shaaban K.; Mague, Joel T.. The article contains the following contents:

The starting compounds tetrahydroisoquinoline-3-thiones I [Ar = Ph, 4-ClC6H4] were synthesized and reacted with N-aryl-2-chloroacetamides in the presence of sodium acetate to produce 7-acetyl-8-aryl-3-(N-arylcarbamoylmethylsulfanyl)-4-cyano-1,6-dimethyl-6-hydroxy-5,6,7,8-tetrahydroisoquinolines II [R = H, Me, OMe, Cl, NO2]. Upon heating in ethanol containing sodium ethoxide, they underwent intramol. Thorpe-Zeigler cyclization, affording the corresponding 7-acetyl-1-amino-6-aryl-2-(N-arylcarbamoyl)-5,8-dimethyl-8-hydroxy-6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines III [X = NH2]. Compounds III [R = OMe, Cl, NO2; Ar = 4-ClC6H4; X = NH2] were converted into the corresponding 1-(1-pyrrolyl) derivatives III [X = pyrrol-1-yl] by heating with 2,5-dimethoxytetrahydrofuran in glacial acetic acid. Structures of all synthesized compounds were characterized by elemental and spectral analyzes. Also, the crystal structure of compounds II [R = H, Ar = 4-ClC6H4] was determined by X-ray diffraction anal. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3HPLC of Formula: 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.HPLC of Formula: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The author of 《Bottom-Up Synthesis of Graphene Monolayers with Tunable Crystallinity and Porosity》 were Neumann, Christof; Kaiser, David; Mohn, Michael J.; Fueser, Matthias; Weber, Nils-Eike; Reimer, Oliver; Goelzhaeuser, Armin; Weimann, Thomas; Terfort, Andreas; Kaiser, Ute; Turchanin, Andrey. And the article was published in ACS Nano in 2019. Reference of 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

We present a method for a bottom-up synthesis of atomically thin graphene sheets with tunable crystallinity and porosity using aromatic self-assembled monolayers (SAMs) as mol. precursors. To this end, we employ SAMs with pyridine and pyrrole constituents on polycrystalline copper foils and convert them initially into mol. nanosheets-carbon nanomembranes (CNMs)-via low-energy electron irradiation induced crosslinking and then into graphene monolayers via pyrolysis. As the nitrogen atoms are leaving the nanosheets during pyrolysis, nanopores are generated in the formed single-layer graphene. We elucidate the structural changes upon the crosslinking and pyrolysis down to the at. scale by complementary spectroscopy and microscopy techniques including X-ray photoelectron and Raman spectroscopy, LEED, at. force, helium ion, and high-resolution transmission electron microscopy, and elec. transport measurements. We demonstrate that the crystallinity and porosity of the formed graphene can be adjusted via the choice of mol. precursors and pyrolysis temperature, and we present a kinetic growth model quant. describing the conversion of mol. CNMs into graphene. The synthesized nanoporous graphene monolayers resemble a percolated network of graphene nanoribbons with a high charge carrier mobility (∼600 cm2/(V s)), making them attractive for implementations in electronic field-effect devices. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Guo, Luxia; Li, Jiaqi; Vaccaro, Luigi; Li, Minghao; Gu, Yanlong published their research in Green Chemistry in 2021. The article was titled 《Direct synthesis of N-aryl/alkyl 3-carbonylpyrroles from the Morita-Baylis-Hillman acetate of 2,2-dimethoxyacetaldehyde and a primary amine》.Quality Control of 2,5-Dimethoxytetrahydrofuran The article contains the following contents:

N-Aryl/alkyl 3-carbonylpyrroles are ubiquitous in compounds of biol. and material significance, whereas their synthesis traditionally requires a multistep protocol. Herein, a kalinite catalyzed direct synthesis of N-substituted 3-carbonylpyrroles from a 2,2-dimethoxyacetaldehyde derived Morita-Baylis-Hillman acetate and a primary amine in ethanol is developed. This reaction is scalable and also applicable to the synthesis of JMH-030, JMC-2004 and other bioactive compounds In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Quality Control of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of C6H12O3In 2019 ,《Synthesis of N-substituted pyrrole derivatives via indium-assisted one-pot reduction/N-annulation sequence reaction》 appeared in Heterocycles. The author of the article were Kim, Eungyung; Jeong, Mingyeong; Lee, Hyejeong; Kim, Byeong Hyo. The article conveys some information:

A synthesis strategy toward diverse pyrrole derivatives I (R = n-pentyl, cyclohexyl, 2-chlorophenyl, quinolin-5-yl, etc.) via an indium-mediated one-pot reductive N-annulation reaction has been developed. This protocol provides easy access to versatile N-substituted pyrroles I in the presence of an indium/AcOH co-activation promotor, with excellent yields. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of C6H12O3In 2022 ,《Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-b] Pyrrole Derivatives》 appeared in Molecules. The author of the article were Kamel, Moumen S.; Belal, Amany; Aboelez, Moustafa O.; Shokr, E. Kh.; Abdel-Ghany, H.; Mansour, Hany S.; Shawky, Ahmed M.; El-Remaily, Mahmoud Abd El Aleem Ali Ali. The article conveys some information:

Novel pyrrolo [2,3-b] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chem. structures of the new derivatives were confirmed through spectral anal. Compounds I and II were revealed to be the most effective hypolipidemic agents, with considerable hypocholesterolemic and hypotriglyceridemic effects. They appear to be promising candidates for creating new powerful derivatives with anti-atherosclerotic and hypolipidemic properties. As for antimicrobial activity, some of the tested compounds showed moderate activity against Pseudomonas aeruginosa: compound II revealed an MIC value of 50μg/mL, compared to 25μg/mL for ciprofloxacin. Compound III showed good antimicrobial activity against Staphylococcus aureus, comparable to ciprofloxacin, and roughly half the activity of ampicillin, according to MIC values. Compound IV has an MIC approx. 25% of that of clotrimazole against Candida albicans. Compound IV also showed the highest antioxidant activity with 59% inhibition of radical scavenging activity. Addnl., the cytotoxic activity of these new derivatives was investigated and most of them showed good anticancer activity against the three tested cell lines. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Correlation between Irradiation Treatment and Metabolite Changes in Bactrocera dorsalis (Diptera: Tephritidae) Larvae Using Solid-Phase Microextraction (SPME) Coupled with Gas Chromatography-Mass Spectrometry (GC-MS)》 was published in Molecules in 2022. These research results belong to Shan, Changyao; Li, Baishu; Li, Li; Li, Beibei; Ren, YongLin; Liu, Tao. Reference of 3-Hydroxydihydrofuran-2(3H)-one The article mentions the following:

The metabolites produced by the larvae of Bactrocera dorsalis (Diptera: Tephritidae) exposed to different doses of irradiation were analyzed using solid phase microextraction (SPME) and gas chromatog.-mass spectrometry (GC-MS), and a metabonomic anal. method of irradiated insects based on GC-MS was established. The anal. revealed 67 peaks, of which 23 peaks were identified. The metabolites produced by larvae treated with different irradiation doses were compared by multivariate statistical anal., and eight differential metabolites were selected. Irradiation seriously influenced the fatty acid metabolic pathway in larvae. Using the R platform combined with the method of multivariate statistical anal., changes to metabolite production under four irradiation doses given to B. dorsalis larvae were described. Differential metabolites of B. dorsalis larvae carried chem. signatures that indicated irradiation dose, and this method is expected to provide a reference for the detection of irradiated insects.3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Reference of 3-Hydroxydihydrofuran-2(3H)-one) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Reference of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Towards the preparation of stable cyclic amino(ylide)carbenes》 was published in Molecules in 2020. These research results belong to Steinert, Henning; Schwarz, Christopher; Kroll, Alexander; Gessner, Viktoria H.. HPLC of Formula: 696-59-3 The article mentions the following:

The exptl. and computational studies on the synthesis and stability of CAYCs based on pyrroles with trialkyl onium groups was described. Attempts to isolate two CAYCs with trialkyl phosphonium and sulfonium ylides resulted in the deprotonation of the alkyl groups instead of the formation of the desired CAYCs. In case of the PCy3-substituted system, the corresponding ylide was isolated, while deprotonation of the SMe2-functionalized compound led to the formation of ethene and the thioether. Detailed computational studies on various trialkyl onium groups showed that both the α- and β-deprotonated compounds were energetically favored over the free carbene. The most stable candidates were revealed to be α-hydrogen-free adamantyl-substituted onium groups, for which β-deprotonation was less favorable at the bridgehead position. Overall, the calculations showed that the isolation of CAYCs should be possible, but careful design was required to exclude decomposition pathways such as deprotonations at the onium group. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3HPLC of Formula: 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.HPLC of Formula: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rahmatpour, Ali; Sajjadinezhad, Seyed Mehrzad; Mirkani, Ahmad; Notash, Behrouz published their research in Tetrahedron in 2021. The article was titled 《Regioselective synthesis of di-aromatic ring-fused 2,8-dioxa/dithia bicyclo[3.3.1]nonane derivatives via recyclable polymeric Bronsted acid-catalyzed one-pot tandem formation of multiple chemical C-C/C-O and C-C/C-S bonds》.Application of 696-59-3 The article contains the following contents:

An environmentally benign and straightforward synthetic approach for the assembly of a new class of diverse sym. substituted di-aromatic-fused 2,8-dioxa/dithiabicyclo[3.3.1]nonane derivatives containing methylene-bridged bicyclic framework via reusable cross-linked polystyrene-supported p-toluenesulfonic acid-catalyzed tandem reactions of substituted phenols/selected thiophenol with 1,1,3,3-tetramethoxypropane under neat conditions has been reported in which four new chem. bonds (two C-C/two C-O)-(two C-C/two C-S), two new six-membered cycles, and two new stereogenic tertiary carbon centers were constructed in a single operation. The synthetic utility of this method was also demonstrated. In addition, this present protocol could be successfully extended to the selected naphthols and dihydroxynaphthalenes as the enol partner of phenols with high efficiency. The developed transformation featured high efficiency, the use of com. accessible feedstocks, excellent regioselectivity, simple operation, gram-scale synthesis, and good functional group compatibility. Furthermore, the solvent-free conditions, easily recoverable catalyst, and efficient recycling render the protocol green, economic and sustainable. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-oneOn September 30, 2021 ,《Identification, quantitation and sensorial contribution of lactones in brandies between China and France》 was published in Food Chemistry. The article was written by Li, Yuanyi; Li, Qianqian; Zhang, Baochun; Shen, Chunhua; Xu, Yan; Tang, Ke. The article contains the following contents:

Lactones are important flavor compounds in lots of foodstuffs. They also play an important role in brandy, but have not been studied at large. In this study, solid-phase extraction (SPE) and stir bar sorptive extraction (SBSE) combined with comprehensive two-dimensional gas chromatog. and time-of-flight mass spectrometry (GC x GC-TOFMS) were applied to identify and quantify lactones in brandies between China and France. Totally 17 lactones were identified, four of which were detected only in SBSE. Among them, γ-valerolactone, γ-heptalactone, δ-octalactone, γ-undecanolactone and δ-dodecalactone were detected in brandy for the first time. The results of partial least squares-discriminant anal. (PLS-DA) revealed that lactones distinguished regional characteristics among different brandies. The omission test showed that four lactones (OAV > 1) had direct impact on the aroma of brandy, and other seven lactones at sub-threshold (0.1 < OAV < 1) provided peach and apricot aroma characteristics through synergistic effects. In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yang, Yi-Lin; Li, Shen; Zhang, Fa-Guang; Ma, Jun-An published their research in Organic Letters in 2021. The article was titled 《N-Iodosuccinimide-Promoted [3 + 2] Annulation Reaction of Aryldiazonium Salts with Guanidines to Construct Aminotetrazoles》.Related Products of 696-59-3 The article contains the following contents:

A N-iodosuccinimide (NIS) -promoted [3+2] annulation reaction of aryldiazonium salts ArN2BF4 (Ar = 4-chlorophenyl, naphthalen-2-y, 3-methoxyphenyl, etc.) with guanidines RNHC(=NHHCl)NH2 (R = H, Me, Boc, 4-cyanophenyl, etc.) has been developed for the construction of previously elusive 2-aryl-5-amino-2H-tetrazoles I. This transformation takes advantage of readily available starting materials, proceeds under metal-free, mild and robust conditions, and holds broad functional group compatibility. The utility of this protocol is further manifested via coupling, annulation, deamination, and denitrogenation derivatizations. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Related Products of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Related Products of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem