Li, Ziting; Cui, Shisheng; Yu, Jiayu; Qu, Jiamin; Shi, Jianbing; Tong, Bin; Cai, Zhengxu; Dong, Yuping published an article in 2022. The article was titled 《Amphiphilic and Zwitterionic Multi Arylpyrroles with Near-Infrared Aggregation-Induced Emission for Cell Membrane Imaging》, and you may find the article in ChemNanoMat.Electric Literature of C6H12O3 The information in the text is summarized as follows:
The cell membrane protects the cell stability and balance and participates in various physiol. activities as an exchange channel. Therefore, the real-time monitoring of cell membrane biol. dynamics can help us understand the physiol. state of the current cell. Herein, a type of amphiphilic near IR (NIR) aggregation-induced emission (AIE) mols. was designed and synthesized. Multiarylpyrroles (MAPs) with a dodecyl chain at the 1-position of the pyrrole ring, charged pyridinium sulfonate at the 2,5-position of the pyrrole ring and free rotating aryls at the 3-position of the pyrrole ring can target cell membranes. One of the MAPs, MAP22, had a maximum emission wavelength in the aggregation state of up to 721 nm with a large Stokes shift (∼280 nm). In addition, MAP22 nanoparticles can produce reactive oxygen species (ROS) with a quantum yield of 224%. Therefore, these AIE MAPs are promising candidates for theranostic nanoagents, including NIR fluorescence imaging to target cell membranes and ablate cancer cells by producing ROS. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Electric Literature of C6H12O3)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Electric Literature of C6H12O3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem