Kamel, Moumen S.’s team published research in Molecules in 2022 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3

Synthetic Route of C6H12O3In 2022 ,《Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-b] Pyrrole Derivatives》 appeared in Molecules. The author of the article were Kamel, Moumen S.; Belal, Amany; Aboelez, Moustafa O.; Shokr, E. Kh.; Abdel-Ghany, H.; Mansour, Hany S.; Shawky, Ahmed M.; El-Remaily, Mahmoud Abd El Aleem Ali Ali. The article conveys some information:

Novel pyrrolo [2,3-b] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chem. structures of the new derivatives were confirmed through spectral anal. Compounds I and II were revealed to be the most effective hypolipidemic agents, with considerable hypocholesterolemic and hypotriglyceridemic effects. They appear to be promising candidates for creating new powerful derivatives with anti-atherosclerotic and hypolipidemic properties. As for antimicrobial activity, some of the tested compounds showed moderate activity against Pseudomonas aeruginosa: compound II revealed an MIC value of 50μg/mL, compared to 25μg/mL for ciprofloxacin. Compound III showed good antimicrobial activity against Staphylococcus aureus, comparable to ciprofloxacin, and roughly half the activity of ampicillin, according to MIC values. Compound IV has an MIC approx. 25% of that of clotrimazole against Candida albicans. Compound IV also showed the highest antioxidant activity with 59% inhibition of radical scavenging activity. Addnl., the cytotoxic activity of these new derivatives was investigated and most of them showed good anticancer activity against the three tested cell lines. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem