Synthetic Route of C6H12O3In 2020 ,《1-phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: synthesis, crystal structure and anti-leukemic activity》 appeared in Molbank. The author of the article were Guillon, Jean; Savrimoutou, Solene; Rubio, Sandra; Moreau, Stephane; Pinaud, Noel; Marchivie, Mathieu; Desplat, Vanessa. The article conveys some information:
A multi-step synthesis of 1-phenyl-8-[[4-(pyrrolo[1,2-a]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan4-one using 2-nitroaniline as starting material was reported. Structure characterization of this original pyrrolo[1,2-a]quinoxaline derivative was achieved by FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral anal. This title compound showed interesting cytotoxic potential against several human leukemia cell lines (K562, HL60, and U937 cells). The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Synthetic Route of C6H12O3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem