Jing, Changcheng’s team published research in ACS Central Science in 2020 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Reference of 2,5-Dimethoxytetrahydrofuran

《Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2》 was written by Jing, Changcheng; Mallah, Shahida; Kriemen, Ella; Bennett, Steven H.; Fasano, Valerio; Lennox, Alastair J. J.; Hers, Ingeborg; Aggarwal, Varinder K.. Reference of 2,5-DimethoxytetrahydrofuranThis research focused onthromboxane A2 fluorinated preparation platelet aggregation induction; hydrolysis kinetics fluorinated thromboxane A2. The article conveys some information:

Platelet activation results in the generation of thromboxane A2 (TxA2), which promotes thrombus formation by further amplifying platelet function, as well as causing vasoconstriction. Due to its role in thrombus formation and cardiovascular disease, its production is the target of antiplatelet drugs such as aspirin. However, the study of TxA2-stimulated cellular function has been limited by its instability (t1/2 = 32 s, pH = 7.4). Although more stable analogs such as U46619 and difluorinated 10,10-F2-TxA2 have been prepared, we targeted a closer mimic to TxA2 itself, monofluorinated 10-F-TxA2, since the number of fluorine atoms can affect function. Key steps in the synthesis of F-TxA2 included α-fluorination of a lactone bearing a β-alkoxy group, and a novel synthesis of the strained acetal. F-TxA2 was found to be 105 more stable than TxA2, and surprisingly was only slightly less stable than F2-TxA2. Preliminary biol. studies showed that F-TxA2 has similar potency as TxA2 toward inducing platelet aggregation but was superior to F2-TxA2 in activating integrin αIIbβ3. The synthesis is described of 10-F-thromboxane A2 I, a stable mimic of TxA2 (105 x more stable) with similar potency as TxA2 toward inducing platelet aggregation. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Aldakheel, Reem K.’s team published research in Pharmaceuticals in 2020 | CAS: 19444-84-9

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Category: tetrahydrofurans

The author of 《Bactericidal and in vitro cytotoxicity of Moringa oleifera seed extract and its elemental analysis using laser-induced breakdown spectroscopy》 were Aldakheel, Reem K.; Rehman, Suriya; Almessiere, Munirah A.; Khan, Firdos A.; Gondal, Mohammed A.; Mostafa, Ahmed; Baykal, Abdulhadi. And the article was published in Pharmaceuticals in 2020. Category: tetrahydrofurans The author mentioned the following in the article:

In the current study, we present the correlation between the capability of laser-induced breakdown spectroscopy (LIBS) to monitor the elemental compositions of plants and their biol. effects. The selected plant, Moringa oleifera, is known to harbor various minerals and vitamins useful for human health and is a potential source for pharmaceutical interventions. From this standpoint, we assessed the antibacterial and in vitro cytotoxicity of the bioactive components present in Moringa oleifera seed (MOS) extract Detailed elemental anal. of pellets of MOSs were performed via LIBS. Furthermore, the LIBS outcome was validated using gas chromatog.-mass spectrometry (GC-MS). The LIBS signal was recorded, and the presence of the essential elements (Na, Ca, Se, K, Mg, Zn, P, S, Fe and Mn) in the MOSs were examined The bactericidal efficacy of the alc. MOS extract was examined against Escherichia coli (E. coli) and Staphylococcus aureus(S. aureus) by agar well diffusion (AWD) assays and SEM (SEM), which depicted greater inhibition against Gram-pos. bacteria. The validity and DNA nuclear morphol. of human colorectal carcinoma cells (HCT-116) cells were evaluated via an MTT assay and DAPI staining. The MTT assay results manifested a profoundly inhibitory action of MOS extract on HCT116 cell growth. Addnl., MOS extracts produced inhibitory action in colon cancer cells (HCT-116), whereas no inhibitory action was seen using the same concentrations of MOS extract on HEK-293 cells (non-cancerous cells), suggesting that MOS extracts could be non-cytotoxic to normal cells. The antibacterial and anticancer potency of these MOS extracts could be due to the presence of various bioactive chem. complexes, such as Et ester and D-allose and hexadecenoic, oleic and palmitic acids, making them an ideal candidate for pharmaceutical research and applications. The results came from multiple reactions, including the reaction of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Category: tetrahydrofurans)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Afsina, C. M. A.’s team published research in Results in Chemistry in 2022 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3

In 2022,Afsina, C. M. A.; Rohit, K. R.; Anilkumar, G. published an article in Results in Chemistry. The title of the article was 《A green protocol for the synthesis of N-aryl pyrroles: A modified Clauson-Kaas approach using zinc catalyst》.Synthetic Route of C6H12O3 The author mentioned the following in the article:

The first zinc-catalyzed simple and convenient protocol for the synthesis of N-substituted pyrroles I (R = H, Me, Cl, etc.; R1 = H, Me, OMe, NO2; R2 = H, OH, I, etc.; R3 = H, Me) through a modified Clauson-Kaas reaction without co-catalyst, ligand, base and solvent has been described. N-substituted pyrroles I were prepared from various aniline derivatives 2-R-3-R1-4-R2-5-R3-C6HNH2 and 2,5-dimethoxytetrahydrofuran under green condition by utilizing low cost, eco-friendly, non-toxic and easily accessible Zn(OTf)2 as catalyst. A wide variety of N-substituted pyrroles I was afforded in moderate to excellent yields from easily available starting materials at 70°C. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Slobodinyuk, Daria G.’s team published research in ChemistrySelect in 2021 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Related Products of 696-59-3

《Synthesis and Investigation of Thermal, Optical and Electrochemical Properties of 2,4,6-Trisubstituted Pyrimidines》 was written by Slobodinyuk, Daria G.; Slobodinyuk, Alexey I.; Shklyaeva, Elena V.; Abashev, Georgii G.. Related Products of 696-59-3This research focused ontrisubstituted pyrimidine preparation UV vis spectra fluorescence redox potential. The article conveys some information:

A number of novel fluorophores have been synthesized containing an electron-withdrawing pyrimidine core and electron donating N,N-dimethylaminophenyl, 4-(9H-carbazol-9-yl)phenyl, Ph and pyrrol-1-yl fragments at positions 2, 4 and 6 of the pyrimidine ring. Thermal, optical and electrochem. properties of these substances have been studied. The structure-property dependences of substituted pyrimidines have been established. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Related Products of 696-59-3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Related Products of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Graves, Brian M.’s team published research in Scientific Reports in 2020 | CAS: 19444-84-9

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Reference of 3-Hydroxydihydrofuran-2(3H)-one

Graves, Brian M.; Johnson, Tyler J.; Nishida, Robert T.; Dias, Ryan P.; Savareear, Benjamin; Harynuk, James J.; Kazemimanesh, Mohsen; Olfert, Jason S.; Boies, Adam M. published their research in Scientific Reports on December 31 ,2020. The article was titled 《Comprehensive characterization of mainstream marijuana and tobacco smoke》.Reference of 3-Hydroxydihydrofuran-2(3H)-one The article contains the following contents:

Recent increases in marijuana use and legalization without adequate knowledge of the risks necessitate the characterization of the billions of nanoparticles contained in each puff of smoke. Tobacco smoke offers a benchmark given that it has been extensively studied. Tobacco and marijuana smoke particles are quant. similar in volatility, shape, d. and number concentration, albeit with differences in size, total mass and chem. composition Particles from marijuana smoke are on average 29% larger in mobility diameter than particles from tobacco smoke and contain 3.4 times more total mass. New measurements of semivolatile fractions determined that >97% of the mass and volume of the particles from either smoke source are comprised of semivolatile compounds For tobacco smoke and marijuana smoke, resp., 4350 and 2575 different compounds are detected, of which 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause neg. health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms. This study demonstrates striking similarities between marijuana and tobacco smoke in terms of their phys. and chem. properties. In the experiment, the researchers used many compounds, for example, 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Reference of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Reference of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ren, Fei’s team published research in Materials Chemistry Frontiers in 2019 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application of 696-59-3

Application of 696-59-3In 2019 ,《Effects of fused rings linked to the 2,5-position of pyrrole derivatives with near-infrared emission on their aggregation-enhanced emission properties》 appeared in Materials Chemistry Frontiers. The author of the article were Ren, Fei; Shi, Jianbing; Tong, Bin; Cai, Zhengxu; Dong, Yuping. The article conveys some information:

Fluorescent materials with near-IR (NIR) emission are important kinds of functional dyes for bioimaging and medical diagnosis. In this work, a type of pyrrole derivative with NIR emission was designed and synthesized through the introduction of different fused rings at the 2,5-position of pyrrole (MAP) and a furanylidene (FE) group at the 3-position of pyrrole (MAP-FE), which constructed a typical donor-π bridge-acceptor (D-π-A) structure. All MAP-FEs have shown aggregation-enhanced emission (AEE) properties. Different fused rings or different positions of substitution on the same fused ring had significant effects on the NIR photoluminescence (PL) properties. In addition, by comparison with the change in the radiative and nonradiative rates of the precursor MAPs and MAP-FEs in solution and the solid state, it can be concluded that the rings fused to the 2,5-position of pyrrole have a two-sided effect on the PL properties of organic dyes: one effect is an improvement in the quantum yield, and the other effect causes a π-π stacking interaction that is unfavorable for emission. The introduction of FE groups as acceptors in MAP-FEs not only red shifted emission wavelengths but also effectively avoided π-π stacking in the aggregated state, which are beneficial for PL properties. These results could provide general guidance for designing NIR dyes with AEE characteristics when using fused rings to improve their PL properties. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Application of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Xinfeng’s team published research in New Journal of Chemistry in 2020 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Electric Literature of C6H12O3

Electric Literature of C6H12O3In 2020 ,《Terminal methyl as a one-carbon synthon: Synthesis of quinoxaline derivatives via radical-type transformation》 appeared in New Journal of Chemistry. The author of the article were Wang, Xinfeng; Liu, Huanhuan; Xie, Caixia; Zhou, Feiyu; Ma, Chen. The article conveys some information:

An iron-promoted method for the construction of pyrrolo[1,2-a]quinoxaline derivatives I [R1 = H, 7-Me, 7-Br, 8-Cl, etc., R2 = H, Me, X, Y = CH, N] and indolo[1,2-a]quinaxaline derivatives II [R3 = H, 3-F, 2-OMe, etc., R4 = H, Me] was developed via sp3 C-H activation and oxidative cyclization of pyrrolyl-anilines/indolyl-anilines and various carbon sources. This method has many advantages including the availability of raw materials, simple operation, reaction efficiency, universal solvent applicability and wide substrate scope. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Electric Literature of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Electric Literature of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Coutinho, Nathalia M.’s team published research in Food Chemistry in 2019 | CAS: 19444-84-9

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one

《Processing chocolate milk drink by low-pressure cold plasma technology》 was written by Coutinho, Nathalia M.; Silveira, Marcello R.; Fernandes, Leonardo M.; Moraes, Jeremias; Pimentel, Tatiana C.; Freitas, Monica Q.; Silva, Marcia C.; Raices, Renata S. L.; Ranadheera, C. Senaka; Borges, Fabio O.; Neto, Roberto P. C.; Tavares, Maria Ines B.; Fernandes, Fabiano A. N.; Fonteles, Thatyane V.; Nazzaro, Filomena; Rodrigues, Sueli; Cruz, A. G.. Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one And the article was included in Food Chemistry on April 25 ,2019. The article conveys some information:

This study aimed to evaluate the effect of the process time (5, 10, and 15 min) and flow rate (10, 20, and 30 mL/min) of cold plasma technol. on physio-chem. characteristics (pH), bioactive compounds (DPPD, Total Phenolic Compounds, ACE-inhibitory activity values), fatty acid composition, and volatile compounds profile of chocolate milk drink. The mild (lower flow rate and process time) and more severe (higher flow rate and process time) conditions led to a reduction of the bioactive compounds (total phenolic compounds and ACE-inhibitory activity), changes in fatty acid composition (increased saturated fatty acid and decreased monounsaturated fatty acid and polyunsaturated fatty acid), less favorable health indexes (higher atherogenic, thrombogenic and hypercholesterolemic saturated fatty acids and lower desired fatty acids), and lower number of volatile compounds In contrast, in intermediate cold plasma conditions, an adequate concentration of bioactive compounds, fatty acid composition, and health indexes, and increased number of volatile compounds (ketones, esters, and lactones) were observed Overall, cold plasma technol. has proven to be an interesting alternative to chocolate milk drinks, being of paramount importance the study of the cold plasma process parameters. In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Application In Synthesis of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xue, Rui’s team published research in Industrial Crops and Products in 2022 | CAS: 696-59-3

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Recommanded Product: 2,5-Dimethoxytetrahydrofuran

《The composition, physicochemical properties, antimicrobial and antioxidant activity of wood vinegar prepared by pyrolysis of Eucommia ulmoides Oliver branches under different refining methods and storage conditions》 was written by Xue, Rui; Cui, Er-Liang; Hu, Guo-Quan; Zhu, Ming-Qiang. Recommanded Product: 2,5-DimethoxytetrahydrofuranThis research focused onWV EUO pyrolysis refining storage antimicrobial antioxidant physicochem property. The article conveys some information:

To enhance the quality of wood vinegar (WV), the WV prepared by pyrolyzing Eucommia ulmoides Oliver (EUO) branches at the temperature of 650°C were refined by using different physicochem. methods. The crude WV was refined by ultra-low freezing and thawing (WVFT), charcoal adsorption (WVCA), and activated carbon adsorption (WVACA), resp. Meanwhile, the chem. compositions, antimicrobial and antioxidant activity of the crude WV (WVC), the WV (WVS) prepared two years ago, and the photolysis WV (WVP) were investigated. The results showed that the WVFT obtained by ultra-low freezing and thawing method possessed better quality with pH of 3.45, d. of 1.045 g/cm3 , refractive index of 26.85% and total organic acid of 11.00%. It was also found that WVFT had better inhibition rate of 83.33% against Bacterium prodigiosum, indication the excellent antibacterial activity. Moreover, WVFT had significant effect on scavenging rate (98.72%) for hydroxyl radicals. This research could offer some references for the refining methods of WV, and the WV was expected to be a potential candidate for materials of antioxidant and antimicrobial. In the experiment, the researchers used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Recommanded Product: 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Recommanded Product: 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Jin, Feng-min’s team published research in Zhongguo Xinyao Zazhi in 2015 | CAS: 160709-02-4

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).HPLC of Formula: 160709-02-4

HPLC of Formula: 160709-02-4On March 15, 2015, Jin, Feng-min; Zhang, Jing published an article in Zhongguo Xinyao Zazhi. The article was 《Synthesis of posaconazole》. The article mentions the following:

Objective: To improve the synthesis process of posaconazole. Methods: Posaconazole was synthesized from 1-(1-bromomethyl-vinyl)-2,4-difluoro-benzene by several reactions such as esterification, reduction and enzymic acetylation. Results: The overall yield was 27.7%. Conclusion: This synthetic process had the advantages of simpler purifying operation, lower cost and mild condition, so it could be used in industrial manufacturing In the experiment, the researchers used many compounds, for example, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4HPLC of Formula: 160709-02-4)

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).HPLC of Formula: 160709-02-4

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem