COA of Formula: C6H12O3In 2021 ,《PEG-400 as a carbon synthon: highly selective synthesis of quinolines and methylquinolines under metal-free conditions》 appeared in Green Chemistry. The author of the article were Ding, Chengcheng; Li, Shichen; Feng, Kaili; Chen, Ma. The article conveys some information:
A metal-free, peroxide-free, and efficient procedure for the highly selective synthesis of quinolines and methylquinolines I (R = H, Me; R1 = H, Me; R2 = H, Me; R3 = H, OMe, F, Ph, etc.; R4 = H, Me; R3R4 = -CH=CH-CH=CH-; R5 = Ph, 3-chlorophenyl, 4-fulorophenyl, etc.) was reported. The main feature of this method was that the same substrate can produce quinolines and methylquinolines, I resp., under different reaction conditions. PEG-400 was used as both a reactant and solvent in this reaction. The utility of the designed procedure was also demonstrated by the derivatization of the products to bioactive compds II. After reading the article, we found that the author used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3COA of Formula: C6H12O3)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.COA of Formula: C6H12O3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem