Chen, Yuce; Cao, Xiaofeng; Chen, Xi; Li, Zhong; Xu, Xiaoyong published their research in Journal of Chemical Research in 2021. The article was titled 《The structure modification of seven-membered aza-brigded neonicotinoids in order to investigate their impact on honey bees》.Name: 2,5-Dimethoxytetrahydrofuran The article contains the following contents:
In order to explore the relationship between the structure and the toxicity to honey bees of seven-membered aza-bridged neonicotinoids, 16 novel seven-membered aza-bridged neonicotinoid analogs are synthesized by replacing the pyridine ring, and changing the substituents on the pyridine ring, the electron-withdrawing group NO2 and the imidazole ring of authors’ previously developed aza-bridged neonicotinoid 1-[(6-chloropyridin-3-yl)methyl]-10-(2,5-dimethylphenyl)-9-nitro-2,3,5,6,7,8-hexahydro-1H-5,8-epiminoimidazo azepine. The insecticidal bioactivities against cowpea aphid (Aphis craccivora) and the bee toxicities of these compounds are tested. Some of the title compounds present good insecticidal activities against cowpea aphid. The results also show that some of the title compounds exhibit lower bee toxicity than that of 1-[(6-chloropyridin-3-yl)methyl]-10-(2,5-dimethylphenyl)-9-nitro-2,3,5,6,7,8-hexahydro-1H-5,8-epiminoimidazo azepine and imidacloprid. This suggests that changing the substituents on the neonicotinoids can influence the toxicity toward honey bees of these analogs. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Name: 2,5-Dimethoxytetrahydrofuran)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Name: 2,5-Dimethoxytetrahydrofuran
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem