In 2022,Afsina, C. M. A.; Rohit, K. R.; Anilkumar, G. published an article in Results in Chemistry. The title of the article was 《A green protocol for the synthesis of N-aryl pyrroles: A modified Clauson-Kaas approach using zinc catalyst》.Synthetic Route of C6H12O3 The author mentioned the following in the article:
The first zinc-catalyzed simple and convenient protocol for the synthesis of N-substituted pyrroles I (R = H, Me, Cl, etc.; R1 = H, Me, OMe, NO2; R2 = H, OH, I, etc.; R3 = H, Me) through a modified Clauson-Kaas reaction without co-catalyst, ligand, base and solvent has been described. N-substituted pyrroles I were prepared from various aniline derivatives 2-R-3-R1-4-R2-5-R3-C6HNH2 and 2,5-dimethoxytetrahydrofuran under green condition by utilizing low cost, eco-friendly, non-toxic and easily accessible Zn(OTf)2 as catalyst. A wide variety of N-substituted pyrroles I was afforded in moderate to excellent yields from easily available starting materials at 70°C. The experimental process involved the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Synthetic Route of C6H12O3)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Synthetic Route of C6H12O3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem