Day: October 18, 2022

Bai, Wu; Hu, Zhizhi; Lu, Yunhua; Xiao, Guoyong; Zhao, Hongbin; Zhu, Jianmin; Liu, Zhaobin published the artcile< Solubility, thermal and photoluminescence properties of triphenyl imidazole-containing polyimides>, COA of Formula: C8H4O6, the main research area is triphenyl imidazole polyimide preparation solubility thermal photoluminescence property.

In this paper, three kinds of tri-Ph imidazole-containing diamines including 2-phenyl-4,5-bis(4-(4-amino-2-trifluoromethylphenoxy)phenyl)imidazole (PBAI), 2-(4-methylphenyl)-4,5-bis(4-(4-amino-2-trifluoromethyl phenoxy)phenyl)imidazole (MPBAI) and 2-(4-trifluoromethylphenyl)-4,5-bis(4-(4-amino-2-trifluoromethylphenoxy)phenyl)imidazole (TFPBAI) were synthesized. Then, a series of polyimide (PI) films were prepared by the solution polymerization of the three diamines and various dianhydrides, such as 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA), 1,2,4,5-pyromellitic dianhydride (PMDA) and 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), followed by thermal imidization. The effects of chem. structures on the solubilities and thermal, optical and electrochem. properties of polyimides were explored. All the polyimides exhibited higher glass transition temperatures around 300°C and excellent solubilities in common polar solvents. The polyimide films derived from CBDA or 6FDA showed better optical properties with light color and transparent characteristics. The fluorescence test showed that the photoluminescence color of CBDA-based polyimide films is in the blue range in the CIE 1931 spectrum, while the polyimide film based on PMDA and 6FDA presented black or weak yellow light. However, all these polyimides in solution exhibited similar blue luminescence. Electrochem. tests indicated that the HOMO and LUMO values of these films were around -6.5 and -3.6 eV, and the energy gap difference was about 3.0 eV. Therefore, the tri-Ph imidazole-containing polyimides exhibit comprehensive performance, which will be expected as a new kind of functional material for certain application in the optical and optoelectronics fields.

RSC Advances published new progress about Absorption. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, COA of Formula: C8H4O6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Gupta, Neil; Mbituyumuremyi, Aimable; Kabahizi, Jules; Ntaganda, Fabien; Muvunyi, Claude Mambo; Shumbusho, Fabienne; Musabeyezu, Emmanuel; Mukabatsinda, Constance; Ntirenganya, Cyprien; Van Nuil, Jennifer Ilo; Kateera, Fredrick; Camus, Gregory; Damascene, Makuza Jean; Nsanzimana, Sabin; Mukherjee, Joia; Grant, Philip M published the artcile< Treatment of chronic hepatitis C virus infection in Rwanda with ledipasvir-sofosbuvir (SHARED): a single-arm trial.>, Product Details of C9H13N2O9P, the main research area is .

BACKGROUND: Limited treatment data are available for hepatitis C virus (HCV) in sub-Saharan Africa, especially for genotype 4. Our objective was to establish the safety and efficacy of ledipasvir-sofosbuvir for chronic HCV genotype 1 or 4 infection in adults in Rwanda. METHODS: We did a single-arm trial to evaluate the safety and efficacy of ledipasvir-sofosbuvir in Rwandan adults with chronic HCV infection at a single study site (Rwanda Military Hospital, Kigali, Rwanda). We enrolled individuals aged 18 years or older with HCV genotype 1 or 4 infection and a plasma HCV RNA concentration of more than 1000 IU/mL at screening. All participants were given ledipasvir (90 mg) and sofosbuvir (400 mg) in a single combination tablet once daily for 12 weeks. We established HCV genotype using an Abbott platform, and HCV subtype with PCR amplification. The primary endpoint was the proportion of participants with a sustained virological response 12 weeks after therapy (SVR12). All patients enrolled in the study were included in the primary endpoint analyses. This study is registered with ClinicalTrials.gov, number NCT02964091. FINDINGS: 300 participants were enrolled between Feb 6, 2017, and Sept 18, 2017, and the follow-up period was completed on March 1, 2018. On genotyping, 248 (83%) participants were reported as having genotype 4, four (1%) genotype 1, and 48 (16%) both genotype 1 and genotype 4. Subsequent viral sequencing showed all participants actually had genotype 4 infection with subtype 4k (134 [45%]), subtype 4r (48 [16%]), subtype 4q (42 [14%]), and subtype 4v (24 [8%]) predominating. Overall, 261 (87%, 95% CI 83-91) participants achieved SVR12. In participants with genotype 4r, SVR12 was observed in 27 (56%, 95% CI 41-71) participants versus 234 (93%, 90-96) individuals with other subtypes. There were no drug-related treatment discontinuations due to ledipasvir-sofosbuvir. The most common adverse events were hypertension (97 [32%]), headache (78 [26%]), dizziness (61 [20%]), and fatigue (56 [19%]). There were six serious adverse events; none were assessed to be due to the study drug. 296 participants had data for pill counts at week 4 and 8; 271 (92%) had 100% adherence and only one (<1%) had an adherence of less than 90%. INTERPRETATION: This is the first large-scale prospective study reporting direct-acting antiviral outcomes in sub-Saharan Africa. The high adherence and treatment success without intensive support measures or highly specialised clinical providers, and lack of treatment discontinuations due to adverse events support the feasibility of HCV treatment decentralisation and scale-up in sub-Saharan Africa. Genotype 4r is uniquely expressed in this region and associated with high rates of treatment failure, suggesting a need for rigorous test-of-cure in clinical practice and consideration of the use of newer pangenotypic direct-acting antiviral regimens in this region. FUNDING: Gilead Sciences. The lancet. Gastroenterology & hepatology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yusof, Fitri Adila Amat; Noda, Takumi; Takada, Kenji; Kaneko, Tatsuo; Kawai, Mika; Mitsumata, Tetsu published the artcile< Critical Electric Field and Activation Energy for Electric Conductivity for Biopolyimide Using 4,4'-Diamino-α-truxillic Acid and 1,2,3,4-Cyclobutanetetracarboxylic Dianhydride>, Formula: C8H4O6, the main research area is biopolyimide preparation elec property.

Biopolyimides poly(ATA-CBDA) made from of 4,4′-diamino-α-truxillic acid di-Me ester (ATA) and 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA) were synthesized and its elec. volume resistivity measured at various elec. voltages at 10-60°C. The volume resistivity for Kapton and biopolyimide films showed a sudden decrease at a critical elec. field of 2.6 x 107 and 1.0 x 107 V/m, resp. The activation energy at low elec. field for Kapton and biopolyimide was 68 and 90 kJ/mol, resp., meanwhile at high elec. field for Kapton and biopolyimide was 45 and 74 kJ/mol, resp. These results indicate that the carriers for elec. conduction for biopolyimide weakly interact with the polymer chain and the biopolyimide contains many conductive carriers than Kapton.

Chemistry Letters published new progress about Activation energy (of volume resistivity). 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Formula: C8H4O6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ueno, M.; Kitagawa, H.; Ishitani, H.; Yasuda, S.; Hanada, K.; Kobayashi, S. published the artcile< Catalytic enantioselective synthesis of a novel inhibitor of ceramide trafficking, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (HPA-12)>, HPLC of Formula: 137105-97-6, the main research area is HPA12 hydroxyhydroxymethylphenylpropyldodecanamide catalytic enantioselective synthesis ceramide trafficking inhibitor; enantioselective zirconium catalyzed Mannich reaction HPA12 synthesis.

A novel inhibitor of ceramide trafficking, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (HPA-12, I), has been synthesized using a chiral zirconium-catalyzed asym. Mannich-type reaction as a key-step.

Tetrahedron Letters published new progress about Mannich reaction (enantioselective zirconium-catalyzed). 137105-97-6 belongs to class tetrahydrofurans, and the molecular formula is C9H15NO4, HPLC of Formula: 137105-97-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hirai, Hajime; Ueda, Kenzo; Matsui, Masanao published the artcile< Studies on chrysanthemic acid. Part XXV. Alternative synthesis of chrysanthemic acid via tetrahydrofuran derivatives>, Application of C8H14O2, the main research area is chrysanthemic acid insecticide; chloromethylchloroisopropylhexanoic acid ester.

The olefination reaction between 2,2,5,5-tetramethyltetrahydrofuran-3-one and (EtO)2P(:O)CH2CO2Et afforded an isomeric mixture of the normal α,β-unsaturated ester (I) and the endocyclic β,γ-unsaturated ester (II). Catalytic hydrogenation and subsequent hydrolysis of the mixture gave 2,2,5,5-tetramethyltetrahydrofuryl-3-acetic acid III. III was treated with SOCl2 in the presence of ZnCl2 to give Me2CClCH(CH2CO2Et)CH2CClMe2, from which trans-chrysanthemic acid was obtained by a known method. Pyrocin was also obtained in good yield by heating III with BF3-etherate.

Agricultural and Biological Chemistry published new progress about Insecticides. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Application of C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Padidam, Sneha; Burke, Marie T; Apple, Daniel B; Hu, Jonathan K; Lin, Xihui published the artcile< Association of Ledipasvir-Sofosbuvir Treatment With Uveitis in Patients Treated for Hepatitis C.>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is .

Importance: Ledipasvir-sofosbuvir has become the current standard of care for hepatitis C since its release in 2014. Therefore, potential adverse effects are important to identify. Objective: To report findings of uveitis after treatment with ledipasvir-sofosbuvir for hepatitis C. Design, Setting, and Participants: This case series includes patients treated in an urban academic setting with ledipasvir-sofosbuvir for hepatitis C from June 2015 to June 2017 who are known to have developed signs and symptoms of posterior uveitis. Exposures: All patients had been treated with ledipasvir-sofosbuvir for hepatitis C for a total of 12 weeks. All patients but 1 had finished treatment prior to presentation. Main Outcomes and Measures: Signs of posterior uveitis on ophthalmic testing. Results: Data were collected from 6 patients (median age, 64.5 [range, 54-72] years). Five patients were male; 4 were white, and 2 were African American. The mean (SD) time between beginning of treatment and presentation was 8.8 (5.5) months. Both eyes were affected in 3 of the 6 patients (total, 9 eyes). The median presenting visual acuity in affected eyes was 20/40 (range, 20/20-20/70). All patients had a negative systemic uveitis workup. Five patients presented with blurred vision, and 1 had a paracentral scotoma. The main ocular findings were peripheral vasculitis (in 8 of 9 eyes), papillitis (in 7 of 9 eyes), and cystoid macular edema (in 6 of 9 eyes). The median follow-up was 8 (range, 4-13) months. The median final visual acuity was 20/40 (range, 20/20-20/200). Conclusions and Relevance: In these patients, it appears that treatment with ledipasvir-sofosbuvir for hepatitis C was associated with a mild posterior uveitis different than interferon retinopathy. Given the large number of patients treated with ledipasvir-sofosbuvir, these findings cannot be considered causative, and an association cannot be quantified at this time.

JAMA ophthalmology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Zhuo-Fei; Shen, Yan; Cui, Wen-Gang; Zhang, Qiang; Hu, Tong-Liang published the artcile< MOF derived non-noble metal catalysts to control the distribution of furfural selective hydrogenation products>, Application In Synthesis of 97-99-4, the main research area is metal organic framework catalyst furfural selective hydrogenation.

Furfural, as one of the most important and attractive platform mols., could produce high-value chems. through selective hydrogenation, which had attracted wide attention in recent years. Hereon, a ZnCo bimetal ZIF (ZnCo-ZIF-US) was quickly and efficiently prepared by an ultrasonic-assisted method, and a series of nitrogen-doped carbon-coated bimetallic composites (ZnCo-US@NC-T, T refers to the calcination temperature) were prepared by a one-step calcination technique from ZnCo-ZIF-US and their structures were characterized in detail by PXRD, SEM, TEM, and XPS, etc. The obtained ZnCo-US@NC-700 showed higher catalytic performance in the selective hydrogenation of furfural to furfuryl alc. than the derivatives of ZnCo bimetal ZIF prepared without ultrasonic-assisted. Surprisingly, the results showed the presence or absence of Zn in the catalysts could regulate the hydrogenation products of furfural to produce furfuryl alc. or tetrahydrofurfuryl alc. In addition, the catalyst could be recycled with almost no significant change in catalytic performance and its microstructure was still well maintained. This work provides an ingenious strategy for the selective regulation of biomass products.

Molecular Catalysis published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application In Synthesis of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hou, Yafei; Pei, Xiaodan; Wang, Yuancheng; Zhang, Luyuan; Wei, Xiaohui; Mao, Hongyan; Zhao, Wuduo; Zhang, Shusheng; Zhang, Wenfen published the artcile< Selective Detection of Nucleotides in Infant Formula Using an N-Rich Covalent Triazine Porous Polymer>, Application of C9H13N2O9P, the main research area is dibenzofuran cyanuric chloride copolymer covalent triazine framework adsorption property; covalent triazine-based frameworks; nucleotides; solid-phase extraction.

The aromatic structure and the rich nitrogen content of polymers based on covalent triazine-based frameworks (CTF) and their unique hydrophilic-lipophilic-balanced adsorption properties make them promising candidates for an adsorbent that can be used for sample pretreatment. Herein, a new covalent triazine-based framework (CTF-DBF) synthesized by a Friedel-Crafts reaction was used for the determination of the content of nucleotides in com. infant formula. It was shown that the synthetic materials had an amorphous microporous structure, a BET surface area of up to 595.59 m2/g, and 0.39 nm and 0.54 nm micropores. The versatile adsorption properties of this material were evaluated by quantum chem. theory calculations and batch adsorption experiments using five nucleotides as probes. The quantum chem. results demonstrated that CTF-DBF can participate in multiple interactions with nucleotides. All the analyses performed present good linearity with R2 > 0.9993. The detection limits of targets ranged from 0.3 to 0.5 mg/kg, the spiked recoveries were between 85.8 and 105.3% and the relative standard deviations (RSD, n = 6) were between 1.1 and 4.5%. All these results suggest that this versatile CTF-DBF has great potential for sample pretreatment.

Nanomaterials published new progress about Adsorbents. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Du, Hong; Ma, Xiuyun; Jiang, Miao; Yan, Peifang; Conrad Zhang, Z. published the artcile< Highly efficient Cu/SiO2 catalyst derived from ethanolamine modification for furfural hydrogenation>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is copper SiO2 catalyst ethanolamine furfural hydrogenation.

The production of furfuryl alc. from furfural hydrogenation in gas phase is of great significance for the valorization of biomass. The existing catalyst for this transformation suffers from high cost and complex preparation process. Thus, a highly efficient copper catalyst was developed by a simple impregnation method using ethanolamine modified granular silica as carrier. The catalytic performance was related to the amount of ethanolamine used in modification. Highly dispersed copper with uniform particle size distribution was obtained from appropriate amount of ethanolamine modified granular silica. The ethanolamine modified granular silica (mass ratio between ethanolamine and silica was 3 in the initial modification mixture) supported copper catalyst exhibited the best performance in terms of catalyst lifetime thanks to its maximum amount of Cu0 sites and largest amount of Cu+ sites. A slow deactivation of the catalyst after extended time on stream evaluation is attributed to carbon deposition and slow copper sintering.

Applied Catalysis, A: General published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Prieto, Nathalie; Vignaud, Philippe; Darbon, Remy; Cheucle, Eric; Philippe, Jean-Marc published the artcile< An appropriate and reactive response to the repeated waves of the COVID-19 pandemic by the national medico-psychological network (CUMP) in France.>, SDS of cas: 58-97-9, the main research area is COVID-19; crisis intervention; psychiatric disorders; public health.

INTRODUCTION: France has been impacted by the COVID-19 pandemic. Anxiety, depression, burn out and the high proportion of post-traumatic stress disorder proved to be the most expected troubles caused by this pandemic and the confinement. Medico-psychological emergency units (CUMP) have been solicited at the very early stage of the pandemic because CUMP units are very well known by the French government and systematically associated to emergency plans. METHODS: In this article we describe the process which has been developed to cope with the psychological needs in the general population. At a first level, platforms of volunteers specialised into listening were available. Then those platforms could directly mobilise the CUMP in case of psychiatric disorders. It ran over the whole first wave and it has been reactivated because of the second confinement in France. RESULTS: During the first wave, approximately 1% of all the calls made on the national Covid number required to be redirected to the listening platforms. Of this group, 4% were related to reactive pathology or a psychiatric decompensating that required adapted and specialised care. CONCLUSION: The high rates of psychological distress detected in the general population in recent scientific literature seem discrepant with our findings of relatively low reorientation towards the CUMP. Nevertheless, our study highlights that the response of the CUMP network in France during the first wave was supportive. The second wave displays its adaptability to the public health policies.

The International journal of social psychiatry published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, SDS of cas: 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem