Zhang, Qingfei; Kuang, Gaizhen; He, Shasha; Lu, Hongtong; Cheng, Yilong; Zhou, Dongfang; Huang, Yubin published the artcile< Photoactivatable Prodrug-Backboned Polymeric Nanoparticles for Efficient Light-Controlled Gene Delivery and Synergistic Treatment of Platinum-Resistant Ovarian Cancer>, SDS of cas: 4415-87-6, the main research area is tumor antitumor gene therapy prodrug cisplatin; N3•-assisted photochemical internalization; gene delivery; photoactivatable polymeric nanoparticles; photoactivated chemotherapy; platinum-resistant ovarian cancer.
Combination of chemotherapy and gene therapy provides an effective strategy for cancer treatment. However, the lack of suitable codelivery systems with efficient endo/lysosomal escape and controllable drug release/gene unpacking is the major bottleneck for maximizing the combinational therapeutic efficacy. In this work, we developed a photoactivatable Pt(IV) prodrug-backboned polymeric nanoparticle system (CNPPtCP/si(c-fos)) for light-controlled si(c-fos) delivery and synergistic photoactivated chemotherapy (PACT) and RNA interference (RNAi) on platinum-resistant ovarian cancer (PROC). Upon blue-light irradiation (430 nm), CNPPtCP/si(c-fos) generates oxygen-independent N3• with mild oxidation energy for efficient endo/lysosomal escape through N3•-assisted photochem. internalization with less gene deactivation. Thereafter, along with Pt(IV) prodrug activation, CNPPtCP/si(c-fos) dissociates to release active Pt(II) and unpack si(c-fos) simultaneously. Both in vitro and in vivo results demonstrated that CNPPtCP/si(c-fos) displayed excellent synergistic therapeutic efficacy on PROC with low toxicity. This PACT prodrug-backboned polymeric nanoplatform may provide a promising gene/drug codelivery tactic for treatment of various hard-to-tackle cancers.
Nano Letters published new progress about Animal gene, c-fos Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, SDS of cas: 4415-87-6.
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem