Day: October 17, 2022

Zhang, Qingfei; Kuang, Gaizhen; He, Shasha; Lu, Hongtong; Cheng, Yilong; Zhou, Dongfang; Huang, Yubin published the artcile< Photoactivatable Prodrug-Backboned Polymeric Nanoparticles for Efficient Light-Controlled Gene Delivery and Synergistic Treatment of Platinum-Resistant Ovarian Cancer>, SDS of cas: 4415-87-6, the main research area is tumor antitumor gene therapy prodrug cisplatin; N3•-assisted photochemical internalization; gene delivery; photoactivatable polymeric nanoparticles; photoactivated chemotherapy; platinum-resistant ovarian cancer.

Combination of chemotherapy and gene therapy provides an effective strategy for cancer treatment. However, the lack of suitable codelivery systems with efficient endo/lysosomal escape and controllable drug release/gene unpacking is the major bottleneck for maximizing the combinational therapeutic efficacy. In this work, we developed a photoactivatable Pt(IV) prodrug-backboned polymeric nanoparticle system (CNPPtCP/si(c-fos)) for light-controlled si(c-fos) delivery and synergistic photoactivated chemotherapy (PACT) and RNA interference (RNAi) on platinum-resistant ovarian cancer (PROC). Upon blue-light irradiation (430 nm), CNPPtCP/si(c-fos) generates oxygen-independent N3• with mild oxidation energy for efficient endo/lysosomal escape through N3•-assisted photochem. internalization with less gene deactivation. Thereafter, along with Pt(IV) prodrug activation, CNPPtCP/si(c-fos) dissociates to release active Pt(II) and unpack si(c-fos) simultaneously. Both in vitro and in vivo results demonstrated that CNPPtCP/si(c-fos) displayed excellent synergistic therapeutic efficacy on PROC with low toxicity. This PACT prodrug-backboned polymeric nanoplatform may provide a promising gene/drug codelivery tactic for treatment of various hard-to-tackle cancers.

Nano Letters published new progress about Animal gene, c-fos Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, SDS of cas: 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Agustina Toscanini, M.; Belen Favarolo, M.; Luis Gonzalez Flecha, F.; Ebert, Berit; Rautengarten, Carsten; Bredeston, Luis M. published the artcile< Conserved Glu-47 and Lys-50 residues are critical for UDP-N-acetylglucosamine/UMP antiport activity of the mouse Golgi-associated transporter Slc35a3>, COA of Formula: C9H13N2O9P, the main research area is UDPGlcNAc UDP N acetylglucosamine UMP transporter; mouse Golgi associated transporter Slc35a3; Golgi; UDP-GlcNAc metabolism; antiporter; congenital glycosylation disorder; glycoprotein biosynthesis; membrane protein; membrane transport; secretory pathway; solute carrier family 35 member A3 (SLC35A3); structural model.

Nucleotide sugar transporters (NSTs) regulate the flux of activated sugars from the cytosol into the lumen of the Golgi apparatus where glycosyltransferases use them for the modification of proteins, lipids, and proteoglycans. It has been well-established that NSTs are antiporters that exchange nucleotide sugars with the resp. nucleoside monophosphate. Nevertheless, information about the mol. basis of ligand recognition and transport is scarce. Here, using topol. predictors, cysteine-scanning mutagenesis, expression of GFP-tagged protein variants, and phenotypic complementation of the yeast strain Kl3, we identified residues involved in the activity of a mouse UDP-GlcNAc transporter, murine solute carrier family 35 member A3 (mSlc35a3). We specifically focused on the putative transmembrane helix 2 (TMH2) and observed that cells expressing E47C or K50C mSlc35a3 variants had lower levels of GlcNAc-containing glycoconjugates than WT cells, indicating impaired UDP-GlcNAc transport activity of these two variants. A conservative substitution anal. revealed that single or double substitutions of Glu-47 and Lys-50 do not restore GlcNAc glycoconjugates. Anal. of mSlc35a3 and its genetic variants reconstituted into proteoliposomes disclosed the following: (i) all variants act as UDP-GlcNAc/UMP antiporters; (ii) conservative substitutions (E47D, E47Q, K50R, or K50H) impair UDP-GlcNAc uptake; and (iii) substitutions of Glu-47 and Lys-50 dramatically alter kinetic parameters, consistent with a critical role of these two residues in mSlc35a3 function. A bioinformatics anal. revealed that an EXXK motif in TMH2 is highly conserved across SLC35 A subfamily members, and a 3D-homol. model predicted that Glu-47 and Lys-50 are facing the central cavity of the protein.

Journal of Biological Chemistry published new progress about Golgi apparatus. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, COA of Formula: C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ghobrial, Carolyne; Sobhy, Rodina; Mogahed, Engy; Abdullatif, Hala; El-Karaksy, Hanaa published the artcile< Is sofosbuvir/ledipasvir safe for the hearts of children with hepatitis C virus>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is hepatitis C virus infection heart sofosbuvir ledipasvir safety child; Bradycardia; ECG; HCV; Sofosbuvir.

Symptomatic bradycardia has been reported in adults treated for chronic hepatitis C using sofosbuvir based regimens.We studied the cardiac safety of sofosbuvir/ledipasvir in Egyptian children, treated for chronic hepatitis C. The study included 40 hepatitis C virus infected children and adolescents 12-17 years old, using the combination of sofosbuvir (400 mg)/ledipasvir (90 mg) in a single oral tablet (Harvoni) taken daily for 12 wk. All subjects underwent a baseline standard 12-lead surface Electrocardiog. that was repeated at 4 and 12 wk of therapy. Electrocardiog. parameters (Heart Rate, RR interval, PR interval, QRS, QT interval, corrected QT interval, QT dispersion, JT interval, corrected JT interval, JT dispersion, Tpeak-Tend interval) were compared at the 3 different time points during antiviral therapy.No symptoms related to the cardiovascular system were reported during treatment. There were no cases of symptomatic bradycardia/syncope. Heart rate was noted to be significantly lower and RR and QT intervals were significantly longer in the baseline electrocardiog. Heart rate was significantly lower and RR interval was significantly longer in patients with higher viral load.No adverse cardiovascular events were observed in this group of HCV infected children and adolescents treated with sofosbuvir/ledipasvir. None of the patients developed bradyarrhythmias during treatment.

Digestive and Liver Disease published new progress about Adolescent, mammalian. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yu, Zhenjie; Tian, Hongli; Sun, Kai; Shao, Yuewen; Zhang, Lijun; Zhang, Shu; Duan, Peigao; Liu, Qing; Niu, Shengli; Dong, Dehua; Hu, Xun published the artcile< Impacts of externally added Bronsted and Lewis acid on conversion of furfural to cyclopentanone over Ni/SiC catalyst>, Computed Properties of 97-99-4, the main research area is Bronsted Lewis acid hydrogenation furfural cyclopentanone nickel catalyst; nickel silicon carbide catalyst hydrogenation furfural.

The conversion of furfural to cyclopentanone (CPO) involves not only hydrogenation but also acid-catalysis reactions. The step of the acid-catalysis might be catalyzed by Lewis acid or Bronsted acid or both, which was investigated in this study by employing Ni/SiC, a catalyst with “”clean”” surface containing negligible amounts of acidic sites. Lewis acid (nitrate salts and chloride salts) or Bronsted acid (D008, a solid acid resin catalyst) with externally added to the reaction medium. The results showed that both Lewis acid and Bronsted acid could catalyze the conversion of furfural to CPO. The further hydrogenation of furfuryl alc. (FA) to tetrahydrofurfuryl alc. was main side reaction, which could be suppressed more effectively with the Lewis acid like CrCl3. The yield of CPO could be up to ca. 88.1% with the Ni/SiC-CrCl3 catalytic system. The chelation of CrCl3 with FA stabilized the C=C bond in the furan ring and the hydroxyl group, preventing the side reactions while facilitating CPO formation. The synergistic effects between the cation and anion was essential for the conversion of FA to CPO as the varied nitrate salts or chloride salts chelated with furfural, FA or other reaction intermediates in distinct ways, determining distribution of the products.

Molecular Catalysis published new progress about Bronsted acids Role: CAT (Catalyst Use), USES (Uses). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Computed Properties of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Qian, Yang; Li, Ze-Jun; Du, Xian-Long; Zhang, Qi; Zhao, Yi; Liu, Yong-Mei; Cao, Yong published the artcile< Total hydrogenation of bio-derived furans over supported Ru subnanoclusters prepared via amino acid-assisted deposition>, Formula: C5H10O2, the main research area is titania supported lysine assisted ruthenium catalyst total hydrogenation furan.

Development of a highly efficient and robust catalyst with reduced usage of noble metals is extremely desirable for selective hydrogenations of furan-containing bio-based feedstocks, which represents an attractive and sustainable alternative to petrochem. resources. Herein, we describe a new type of well-dispersed Ru subnanoclusters (ca. 0.50 wt%) supported on com. P25 TiO2 material obtained from a facile and effective amino acid-assisted deposition-precipitation strategy. The as-synthesized catalyst exhibits superior catalytic activity and selectivity for direct hydrogenation of industrially important furfural as well as a range of structurally diverse bio-based furanic compounds to their corresponding fully hydrogenated derivatives An average turnover frequency (ATOF) value as high as 367 h-1 at 80°C and 4 MPa H2 is obtained, which is the highest reported value. This catalyst also shows stable furfural total hydrogenation in 5 reaction cycles conducted at 80°C (52 mmol-scale, turnover number up to 12 500). In terms of the kinetic and structural characterizations, the key performances of the ultrasmall Ru clusters are proposed to mainly originate from an enhanced number of unsaturated surface Ru atoms and change in local coordination environment. Our work highlights the importance of the subnanometric size of Ru clusters in the advancement of efficient and affordable approaches towards bio-based chem. production

Green Chemistry published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rodina, Liudmila L.; Galkina, Olesia S.; Maas, Gerhard; Platz, Matthew S.; Nikolaev, Valerij A. published the artcile< A New Method for C-H Functionalization of Aliphatic Compounds by an Unusual Photochemical Reaction of Diazoketones without Elimination of Nitrogen>, Category: tetrahydrofurans, the main research area is diazotetrahydrofuranone aliphatic compound Wolff rearrangement photochem; hydrazone diazotetrahydrofuranyl preparation; aliphatic compound diazotetrahydrofuranone Wolff rearrangement photochem; bisfuranylhydrazonoethane preparation.

Benzophenone-sensitized reactions of 4-diazotetrahydrofuran-3(2H)-ones with H-donors such as THF, 1,4-dioxane, cyclohexane and di-Et ether, occur without elimination of nitrogen and give rise to the corresponding N-substituted hydrazones or bis-hydrazonoethanes due to a formal insertion of the terminal N atom of diazo group into α-C-H bonds of ethers and aliphatic hydrocarbons, with yields of up to 78 %. Long-wavelength UV irradiation (λ>310 nm) was most suitable for this process, whereas oxygen mols. adequately quench the triplet excited state of the diazoketone and reduce the preparative yields of C-H-insertion products. Hence this photochem. reaction of diazoketones could be used for C-H functionalization of different aliphatic compounds

Asian Journal of Organic Chemistry published new progress about Aliphatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kuronen, Pirjo; Laitalainen, Tarja published the artcile< Crystal and molecular structure and spectra of 2',2',5,5,5',5',7,7-octamethyl-2',5,5',7-tetrahydrofuro[3,4-d]-1-oxa-3,4-diselenin-2-spiro-3'-furan-4'(3'H)-one from selenium dioxide oxidation of 2,2,5,5-tetramethyltetrahydrofuran-3-one. A novel six-membered heterocyclic ring system in the chalcogen series>, Synthetic Route of 5455-94-7, the main research area is tetramethyltetrahydrofuranone oxidation selenium dioxide; tetrahydrofurandione tetramethyl; crystal structure octamethyltetrahydrofurooxadiseleninspirofuranone; spirofuranone octamethyltetrahydrofurooxadiselenin crystal mol structure; furanone octamethyltetrahydrofurooxadiseleninspiro crystal mol structure; mol structure octamethyltetrahydrofurooxadiseleninspirofuranone.

When 2,2,5,5-tetramethyltetrahydrofuran-3-one 1 was oxidized with selenium dioxide in ethanol, the title heterocycle I was formed along with 2,2,5,5-tetramethyltetrahydro-3,4-furandione 2. The diselenide I represents a novel six-membered heterocycle in the chalcogen series.

Journal of Heterocyclic Chemistry published new progress about Crystal structure. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Synthetic Route of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xia, Haihong; Chen, Changzhou; Liu, Peng; Zhou, Minghao; Jiang, Jianchun published the artcile< Selective hydrogenation of furfural for high-value chemicals: effect of catalysts and temperature>, Electric Literature of 97-99-4, the main research area is furfural selective hydrogenation bimetallic catalyst temperature effect.

Transformation of furfural (FFA), a typical representative of furan platform chems. derived from the acid hydrolysis of hemicellulose to the high value chems. tetrahydrofurfuryl alc. (THFOL) and cyclopentanol (CPL), has drawn great attention. In this study, we report an efficient NiCo bimetallic catalyst with highly dispersed NiCo-based metals on a porous carbon matrix for FFA hydrogenation. For different FFA conversion reactions of the bimetallic catalysts, the tetrahydrofurfuryl (THFOL) yield was up to 95% over the Ni3Co1@C catalyst at 80°C. Furthermore, cyclopentanol (CPL) could also be obtained with a yield of 95% with Ni1Co1@C as the catalyst at 160°C in an aqueous medium. The detailed physicochem. characterization was carried out by means of XRD, SEM, BET, ICP, XPS, NH3-TPD and Raman anal. With the addition of Co in the bimetallic catalysts, the average particle size decreased obviously to around 5.7 nm in NixCoy/C catalysts with different Ni/Co ratios, which increased the dispersion and improved the catalytic activity of FFA hydrogenation. The NixCoy@C catalysts could be recovered and efficiently applied in the next run for four consecutive recycling tests in FFA hydrogenation to the corresponding target products under different reaction conditions. The results suggested that the NixCoy@C catalyst appeared to increasingly favor the formation of Ni-Co alloys and suggested a metallic active site in FFA hydrogenation with the addition of the Co element. Mechanistic study indicated that temperature was a key factor contributing to the formation of different desired products (THFOL and CPL). Furthermore, water was another essential factor, which was responsible for the arrangement of the furan compound

Sustainable Energy & Fuels published new progress about Acidity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Electric Literature of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem