Day: October 17, 2022

Zhu, Yanru; Zhao, Wenfang; Zhang, Jian; An, Zhe; Ma, Xiaodan; Zhang, Zhijun; Jiang, Yitao; Zheng, Lirong; Shu, Xin; Song, Hongyan; Xiang, Xu; He, Jing published the artcile< Selective activation of C-OH, C-O-C, or C=C in furfuryl alcohol by engineered Pt Sites supported on layered double oxides>, Product Details of C5H10O2, the main research area is selective activation carbon OH oxygen furfuryl alc engineered.

The selective activation of targeted bonds in biomass-derived furfural or furfuryl alc. with complex chem. linkages (C-C/C-H/C-O, C=C/C=O, or C-O-H/C-O-C) is of great challenge for biomass upgrading, expecting well-defined catalyst and definite catalytically active sites. This work demonstrates an efficient targeted activation to C-OH, C-O-C, or C=C by engineering the structure of catalytic Pt sites, affording 2-methylfuran (2-MF), tetrahydrofurfuryl alc. (THFA), or 1,2-pentanediol (1,2-PeD) as product in the hydroconversion of furfuryl alc. The catalytic Pt sites have been engineered as at. Pt, coordination unsaturated Pt-Pt in atom-thick dispersion, or coordination unsaturated 3D Pt-Pt by tailoring the Pt dispersion (single atom, 2D cluster, or 3D cluster) on Mg and Al-containing layered double oxide (Mg(Al)O) support. The selective activation of C-OH, C-O-C, or C=C has been traced with the FT-IR spectra recorded surface reaction. On at. Pt, C-O-H is easily activated, with the assistance of Mg(Al)O support, with O-terminal adsorption without affecting furan C-O and C=C. However, C=C in the furan ring is easier to be activated on coordination-unsaturated Pt-Pt in atom-thick dispersion, resulting in a step-by-step hydrogenation to generate THFA. On coordination-unsaturated 3D Pt-Pt, the hydrogenolysis of furan ring is favored, resulting in the cleavage of furan C-O to produce 1,2-PeD. Also, the Mg(Al)O supports derived from Mg and Al layered double hydroxides (LDHs) here also play a key role in promoting the selectivity to 1,2-PeD by providing basic sites.

ACS Catalysis published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Buvelot, He Lene; Roth, Myriam; Jaquet, Vincent; Lozkhin, Andrey; Renzoni, Adriana; Bonetti, Eve-Julie; Gaia, Nadia; Laumay, Floriane; Mollin, Michele; Stasia, Marie-Jose; Schrenzel, Jacques; Franc ois, Patrice; Krause, Karl-Heinz published the artcile< Hydrogen peroxide affects growth of S. aureus through downregulation of genes involved in pyrimidine biosynthesis>, Reference of 58-97-9, the main research area is hydrogen peroxide carA pyrimidine Staphylococcus; S. aureus; carA; hydrogen peroxide; neutrophils; pyrimidine metabolism.

Reactive oxygen species (ROS) play a crucial role in the cellular defense against S. aureus, as evidenced by the importance of this pathogen in patients lacking the ROS-generating phagocyte NADPH oxidase NOX2. ROS concentrations required to kill S. aureusin vitro are much higher than those found in the phagosome. We therefore hypothesized that sublethal ROS concentrations may play a role in S. aureus gene dysregulation and investigated the in vitro transcriptomic response of S. aureus to sublethal concentrations of hydrogen peroxide (H2O2). A striking observation of these experiments was a coordinated and massive downregulation of genes involved in pyrimidine metabolism Using transposon insertion mutants, we demonstrated that deletion of carA, a gene involved in pyrimidine synthesis, led to a significant growth defect and to an increased sensitivity of S. aureus to added H2O2. The phenotype of the carA mutant could be reversed through supplementation with the pyrimidine precursor uracil, or with a multicopy vector encoding carA. As opposed to the impact of ROS on extracellular survival, carA deletion did not affect the intracellular survival in neutrophils. Our results raise the possibility that ROS-dependent downregulation of pyrimidine metabolism might be a survival strategy of S. aureus, allowing colonization through intracellular survival, while decreasing the risk of killing the host through dampened extracellular growth.

Frontiers in Immunology published new progress about Homo sapiens. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Reference of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yang, Lutong; Guo, Zhiheng; Yu, Miao; Cai, Xiaokun; Mao, Yingyi; Tian, Fang; Xu, Wenhui; Liu, Guoliang; Li, Xiang; Zhao, Yanrong; Xie, Lin published the artcile< Profile of Nucleotides in Chinese Mature Breast Milk from Six Regions>, Product Details of C9H13N2O9P, the main research area is mature breast milk nucleotides profile chinese; MUAI; breast milk; nucleotides; total potentially available nucleosides.

This study measured the total potentially available nucleoside (TPAN) content in breast milk from six different regions of China as a part of the Maternal Nutrition and Infant Investigation (MUAI) study. A total of 631 breast milk samples were collected from healthy, lactating women with singleton, full-term pregnancies between 40 and 45 days postpartum in Changchun, Chengdu, Lanzhou, Shanghai, Tianjin, and Guangzhou. TPAN and free 5′-monophosphate nucleotide (5′-MNT) contents were determined by high-performance liquid chromatog. The TPAN content of the Chinese mature milk ranged from 11.61 mg/L to 111.09 mg/L, with a median level of 43.26 mg/L. Four types of nucleotides were identified, and the median levels of cytidine monophosphate (CMP), uridine monophosphate (UMP), guanosine monophosphate (GMP), and adenosine monophosphate (AMP) were 22.84 mg/L, 9.37 mg/L, 4.86 mg/L, and 4.80 mg/L, resp. CMP was the predominant nucleotide, accounting for 52.9% of the TPAN content, while free 5′-MNT accounted for 18.38% of the TPAN content. The distribution pattern of the TPAN content and level of the individual nucleotides were significantly different among the selected regions (p < 0.05), but the result showed no significant differences in the TPAN level in breast milk (p > 0.05). In addition, no correlation was reported between the geog. distribution and TPAN levels. This result showed that TPAN better reflects the level of total potential nucleosides in Chinese breast milk rather than 5′-MNT in free form. CMP, UMP, GMP, and AMP are the only 4 types of nucleotides reported in all detections. In addition, results revealed a large variation of TPAN levels in Chinese breast milk across six regions, so that the median value may not be the optimal fortification level of TPAN for Chinese infant populations.

Nutrients published new progress about Age groups. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Barclay, Lawrence R. C.; Young, Robert Hayworth; Adams, Keir Leigh; Foote, Helen M. published the artcile< o-Diquaternary aromatic compounds. IV. Acid-catalyzed rearrangements of poly(alkyltetralones) and related ketones>, Related Products of 5455-94-7, the main research area is tetralone polymethyl rearrangement; methyltetralone rearrangement; acetylindan derivative; indan acetyl methyl.

The ketones 1,1,4,4-tetramethyl-2-tetralone (I), 1,1,4,4,7-pentamethyl-2-tetralone (II), and 1,1,4,4,6-pentamethyl-2-tetralone (III) undergo rearrangement on heating with aluminum chloride or ferric chloride in tetrachloroethane or nitromethane into mixtures of their resp. isomeric ketones, 1-acetyl-1,3,3-trimethylindan and 2,2,4,4-tetramethyl-1-tetralone from I, 1-acetyl-1,3,3,6-tetramethylindan and 2,2,4,4,7-pentamethyl-1-tetralone from II, and 1-acetyl-1,3,3,5-tetramethylindan and 2,2,4,4,6-pentamethyl-1-tetralone from III. A quant. study using g.l.c. of the distribution of the ketones with time shows that the sequence of the rearrangement is: A methyl group homologously para to the carbonyl (in III) accelerates the rearrangement. The same kind of rearrangement takes place during Friedel-Crafts cycloalkylation with 2,2,5,5-tetramethyltetrahydrofuranone. A unifying reaction mechanism is postulated to account for the rearrangements. This mechanism also accounts for the rearrangement and fragmentation products from treatment of 1,1,4,4-tetramethyl-2,3-dioxotetralin (IV) with aluminum chloride or sulfuric-acetic acids. The products from IV include 1-acetyl-1,3,3-trimethyl-2-indanone, 1,1,3-trimethyl-2-indanone, and, from the aluminum chloride-catalyzed rearrangement, 5(or 6)-acetyl-1,1,3-trimethyl-2-indanone.

Canadian Journal of Chemistry published new progress about Alkylation. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Related Products of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bai, Wu; Lu, Yunhua; Hu, Zhizhi; Xiao, Guoyong; Zhao, Hongbin; Zhu, Jianmin; Liu, Zhaobin published the artcile< Photoluminescence, thermal and surface properties of triarylimidazole-containing polyimide nanocomposite films>, Quality Control of 4415-87-6, the main research area is polyimide inorganic filler nanocomposite photoluminescence thermal surface property.

In this work, a triarylimidazole-containing diamine 2-(4-methylphenyl)-4,5-bis(4-(4-amino-2-trifluoromethylphenoxy)phenyl)imidazole (MPBAI) was firstly synthesized and polymerized with 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA) to prepare transparent polyimide (PI) films by means of thermal imidization. Then, inorganic nanoparticles including silica (SiO2), alumina (Al2O3) and silicon nitride (Si3N4) were sep. introduced into the PI(MPBAI-CBDA) with different mass fractions of 0.02%, 0.10%, 0.50% and 2.50% to obtain three series of PI nanocomposite films. All these films were close to colorless and transparent, although the light transmittance showed a downward trend due to the introduction of nanoparticles. Moreover, as the content of inorganic nanoparticles increased, the fluorescence intensities of these films were increased. Comparatively, the improvement effect of nano-SiO2 was the most obvious. When the content of SiO2 was 2.50%, the maximum intensity of the fluorescence absorption peak was increased by 9.6 times, and the absolute fluorescence quantum yield reached 17.2%, about 5.2 times that of the original PI film. Moreover, the maximum absorption peak produced a red shift of 85 nm due to the addition of 2.50% Si3N4, which was probably caused by the weakening of fluorescence quenching effect and high permittivity. The nanocomposites exhibited high glass transition temperatures of around 300°C and excellent thermal stabilities. The surface hydrophobicity was changed by adjusting the mass and type of nanoparticles. Thus, this work provided a simple way to improve the photoluminescence effect by introducing the nanoparticles. The functional films will be expected to be applied in some optical applications.

RSC Advances published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Quality Control of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kosydar, Robert; Kolodziej, Michal; Lalik, Erwin; Gurgul, Jacek; Mordarski, Grzegorz; Drelinkiewicz, Alicja published the artcile< The role of hydrogen bronzes in the hydrogenation of polyfunctional reagents: cinnamaldehyde, furfural and 5-hydroxymethylfurfural over Pd/HxWO3 and Pd/HxMoO3 catalysts>, Category: tetrahydrofurans, the main research area is cinnamaldehyde hydroxymethyl furfural hydrogen bronze hydrogenation palladium catalyst.

Differences in the activity of Pd/WO3 and Pd/MoO3 (Pd loading 0.4-4 weight%) catalysts in competitive hydrogenations of the C=C and C=O groups in polyfunctional reagents have been studied as a function of two effects: (1) the in situ formation of hydrogen bronzes, HxWO3 and HxMoO3, and (2) the electronic interaction between the supports and the metallic Pd. The cinnamaldehyde (CAL), furfural (FU) and 5-hydroxymethylfurfural (HMF) were hydrogenated under mild reaction conditions. The formation of hydrogen bronzes in Pd/WO3 and phys. mixture of Pd/WO3 with supporting WO3 oxide upon exposure to H2 was also studied using the gas flow-through microcalorimetry. In both Pd/MoO3 and Pd/WO3 catalysts, the electronic interactions contributed to the promotion of selectivity toward the C=O hydrogenation in CAL and FU, yet in Pd/MoO3 this effect was much more pronounced. On the other hand, apart from increasing the overall reaction rate, the formation of hydrogen bronzes remarkably enhances the C=C hydrogenation in CAL, as well as the decarbonylation of FU to furan and hydrogenolysis of C-OH in HMF to 5-methylfurfural. The bronze effects are significantly stronger in HxWO3, compared to HxMoO3, which may be related to higher H-species mobility and weaker H-bonding in the W-O-H (54 kJ/mol H2) than in the Mo-O-H (100 kJ/mol H2). This may also explain very high tendency of Pd/WO3 to furan ring hydrogenation in FU and HMF as well as almost selective (>98%) hydrogenation of furfuryl alc. to tetrahydrofurfuryl alc.

International Journal of Hydrogen Energy published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lauer, Matthew G.; Henderson, William H.; Awad, Amneh; Stambuli, James P. published the artcile< Palladium-Catalyzed Reactions of Enol Ethers: Access to Enals, Furans, and Dihydrofurans>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is palladium catalyzed oxidation alkyl enol ether enal furan hydrofuran.

The palladium-catalyzed oxidation of alkyl enol ethers to enals, which employs low loadings of a palladium catalyst, is described. The mild oxidation conditions tolerate a diverse array of functional groups, while allowing the formation of di-, tri-, and tetrasubstituted olefins. The application of this methodol. to intramol. reactions of alkyl enol ethers containing pendant alcs. provides furan and 2,5-dihydrofuran products.

Organic Letters published new progress about Acetalization. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Babatin, Mohammed A; AlGhamdi, Abdullah S; Assiri, Abdullah M; AlBiladi, Haziz; AlOthmani, Hammad S; Mogharbel, Mohammed H; Mahallawi, Wedad; Asselah, Tarik; Sanai, Faisal M published the artcile< Treatment efficacy of ledipasvir/sofosbuvir for 8 weeks in non-cirrhotic chronic hepatitis C genotype 4 patients.>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is Duration; genotype 4; hepatitis C; ledipasvir; sofosbuvir.

BACKGROUND/AIMS: Ledipasvir/sofosbuvir (LDV/SOF) combination is administered for 12 to 24 weeks to treat hepatitis C virus (HCV); guidelines recommend 8 weeks treatment duration for HCV genotype (GT) 1 infection based on the patient’s baseline characteristics. Data on treating HCV GT4 with LDV/SOF are limited. In this prospective cohort study, the efficacy and safety of 8 weeks treatment duration with LDV/SOF was evaluated in HCV GT4 patients in Saudi Arabia. PATIENTS AND METHODS: Treatment-naïve, non-cirrhotic HCV GT4 patients received LDV/SOF for 8 weeks. HCV RNA levels and laboratory evaluations were recorded at baseline and at Weeks 4, 8, and 20. The primary endpoint was sustained virologic response 12 weeks after the end of the treatment (SVR12). Safety data were also recorded. RESULTS: Forty-five patients with a mean age of 43.9 ± 17.2 years participated, of whom 57.8% were male. Mean log10HCV RNA was 6.26 ± 6.32 IU/mL and most (91.1%) had baseline HCV RNA levels <6 million IU/mL. The most frequent comorbidities were hypertension and diabetes mellitus (20.0% each). Concomitant medication was taken by 18 patients (40.0%), of whom two took proton pump inhibitors. Overall, SVR12 was 97.8% (95% confidence interval [CI]: 88.2%-99.9%); one patient (2.2%) relapsed post treatment. No serious adverse events or discontinuations were reported. Eighteen patients (44.4%) had 38 adverse events related to LDV/SOF; the most frequent was headache. CONCLUSIONS: An 8-week regimen of LDV/SOF was well tolerated and efficacious in this treatment-naïve, non-cirrhotic HCV GT4-infected population. This study provides valuable information on a short treatment regimen for HCV GT4 infection in a real-world setting. Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Angiolilli, Chiara; Leijten, Emmerik F. A.; Bekker, Cornelis P. J.; Eeftink, Ella; Giovannone, Barbara; Nordkamp, Michel Olde; van der Wal, Marlot; Thijs, Judith L.; Vastert, Sebastiaan J.; van Wijk, Femke; Radstake, Timothy R. D. J.; van Loosdregt, Jorg published the artcile< ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts>, Formula: C9H13N2O9P, the main research area is zinc finger protein psoriatic dermal fibroblast proinflammatory feature.

Dermal fibroblasts are strategically positioned underneath the basal epidermis layer to support keratinocyte proliferation and extracellular matrix production In inflammatory conditions, these fibroblasts produce cytokines and chemokines that promote the chemoattraction of immune cells into the dermis and the hyperplasia of the epidermis, two characteristic hallmarks of psoriasis. However, how dermal fibroblasts specifically contribute to psoriasis development remains largely uncharacterized. In this study, we investigated through which cytokines and signaling pathways dermal fibroblasts contribute to the inflammatory features of psoriatic skin. We show that dermal fibroblasts from lesional psoriatic skin are important producers of inflammatory mediators, including IL-6, CXCL8, and CXCL2. This increased cytokine production was found to be regulated by ZFP36 family members ZFP36, ZFP36L1, and ZFP36L2, RNA-binding proteins with mRNA-degrading properties. In addition, the expression of ZFP36 family proteins was found to be reduced in chronic inflammatory conditions that mimic psoriatic lesional skin. Collectively, these results indicate that dermal fibroblasts are important producers of cytokines in psoriatic skin and that reduced expression of ZFP36 members in psoriasis dermal fibroblasts contributes to their inflammatory phenotype.

Journal of Investigative Dermatology published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (BHLHE4). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Formula: C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Schwarz, Kathleen B.; Rosenthal, Philip; Murray, Karen F.; Honegger, Jonathan R.; Hardikar, Winita; Hague, Rosie; Mittal, Naveen; Massetto, Benedetta; Brainard, Diana M.; Hsueh, Chia-Hsiang; Shao, Jiang; Parhy, Bandita; Narkewicz, Michael R.; Rao, Girish S.; Whitworth, Suzanne; Bansal, Sanjay; Balistreri, William F. published the artcile< Ledipasvir-Sofosbuvir for 12 Weeks in Children 3 to <6 Years Old With Chronic Hepatitis C>, COA of Formula: C9H13N2O9P, the main research area is chronic hepatitis C infection ledipasvir sofosbuvir efficacy safety.

For children under 12 years of age who have chronic HCV infection, there are currently no approved treatments with direct-acting antiviral agents. We therefore evaluated the safety and efficacy of ledipasvir-sofosbuvir in HCV-infected children aged 3 to <6 years. In an open-label study, patients 3 to <6 years old chronically infected with HCV genotype 1 (n = 33) or 4 (n = 1) received weight-based doses of combined ledipasvir-sofosbuvir as granules (33.75 mg/150 mg for weights <17 kg or 45 mg/200 mg for weights =17 kg) for 12 wk. The primary endpoint was sustained virol. response 12 wk after treatment (SVR12). For the first 14 patients, intensive pharmacokinetic sampling was done on day 10 of treatment. All patients had been infected through perinatal transmission and were treatment naive. No patients had known cirrhosis. Ten patients (29%) weighed <17 kg. SVR12 was achieved in 97% of patients (33 of 34); the patient who did not achieve SVR12 was 3 years old and discontinued treatment after 5 days because of an adverse event ""abnormal drug taste. "" The most common adverse events were vomiting (24% of patients), cough (21%), and pyrexia (21%). No patients experienced a serious adverse event. Intensive pharmacokinetic anal. of 13 patients for whom data were evaluable confirmed that the doses selected were appropriate. Conclusion: Ledipasvir-sofosbuvir was well tolerated and highly effective in children 3 to <6 years old with chronic HCV infection. Hepatology (Hoboken, NJ, United States) published new progress about Child. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, COA of Formula: C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem