Day: October 17, 2022

Modelska, Magdalena; Binczarski, Michal J.; Dziugan, Piotr; Nowak, Szymon; Romanowska-Duda, Zdzislawa; Sadowski, Adam; Witonska, Izabela A. published the artcile< Potential of waste biomass from the sugar industry as a source of furfural and its derivatives for use as fuel additives in Poland>, Related Products of 97-99-4, the main research area is furfural biomass lignocellulosic waste fuel additive.

Poland is one of the leading producers of sugar from sugar beet in Europe. However, the production of sugar generates large amounts of lignocellulosic waste, in the form of beet pulp and leaves. Currently, this waste is not reutilized in the chem. industry, but is only used as food for farm animals. This paper assesses the potential of using bio-waste from the sugar industry as a raw material for the production of furfurals via acid hydrolysis. Further processing of furfural into derivatives such as furfuryl alc. (FA) or tetrahydrofurfuryl alc. (THFA) could increase the economic profitability of the initiative. Furfuryl alc. can be used as a fuel additive in sugar factories. Tetrahydrofurfuryl alc. can be used as a component in agricultural fertilizers, increasing the yield of sugar beet. This approach reduces the amount of post-production waste and brings the sugar industry closer to the concept of a circular economy.

Energies (Basel, Switzerland) published new progress about Beta vulgaris saccharifera, pulp, silage. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Cortese, Melissa; Delporte, Cedric; Dufour, Damien; Noyon, Caroline; Chaumont, Martin; De Becker, Benjamin; Reye, Florence; Rousseau, Alexandre; Omer, Eker; Neve, Jean; Piagnerelli, Michael; Boudjeltia, Karim Zouaoui; Robaye, Bernard; Van Antwerpen, Pierre published the artcile< Validation of a LC/MSMS method for simultaneous quantification of 9 nucleotides in biological matrices>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is UHPLC tandem mass spectrometry nucleotide blood endothelium erythrocyte.

Nucleotides play a role in inflammation processes: cAMP and cGMP in the endothelial barrier function, ADP in platelet aggregation, ATP and UTP in vasodilatation and/or vasoconstriction of blood vessels, UDP in macrophages activation. The aim of this study is to develop and validate a LC/MS-MS method able to quantify simultaneously nine nucleotides (AMP, cAMP, ADP, ATP, GMP, cGMP, UMP, UDP and UTP) in biol. matrixes (cells and plasma). The method we developed, has lower LOQ’s than others and has the main advantage to quantify all nucleotides within one single injection in less than 10 min. The measured nucleotides concentrations obtained with this method are similar to those obtained with assay kits com. available. Anal. of plasma and red blood cells from healthy donors permits to estimate the physiol. concentration of those nucleotides in human plasma and red blood cells, such information being poorly available in the literature. Furthermore, the protocol presented in this paper allowed us to observe that AMP, ADP, ATP concentrations are modified in human red blood cells and plasma after a venous stasis of 4 min compared to physiol. blood circulation. Therefore, this specific method enables future studies on nucleotides implications in chronic inflammatory diseases but also in other pathologies where nucleotides are implicated in.

Talanta published new progress about Aneurysm (post-stenting). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Paraja, Miguel; Hao, Xiaoyu; Matile, Stefan published the artcile< Polyether Natural Product Inspired Cascade Cyclizations: Autocatalysis on π-Acidic Aromatic Surfaces>, Application In Synthesis of 97-99-4, the main research area is oligooxolane preparation; oligoepoxide preparation cascade ring opening cyclization autocatalysis kinetics; autocatalysis; cyclization; polyethers; synthetic methods; π interactions.

Anion-π catalysis functions by stabilizing anionic transition states on aromatic π surfaces, thus providing a new approach to mol. transformation. The delocalized nature of anion-π interactions suggests that they serve best in stabilizing long-distance charge displacements. Aiming therefore for an anionic cascade reaction that is as charismatic as the steroid cyclization is for conventional cation-π biocatalysis, reported here is the anion-π-catalyzed epoxide-opening ether cyclizations of oligomers. Only on π-acidic aromatic surfaces having a pos. quadrupole moment, such as hexafluorobenzene to naphthalenediimides, do these polyether cascade cyclizations proceed with exceptionally high autocatalysis (rate enhancements kauto/kcat >104 M-1). This distinctive characteristic adds complexity to reaction mechanisms (Goldilocks-type substrate concentration dependence, entropy-centered substrate destabilization) and opens intriguing perspectives for future developments.

Angewandte Chemie, International Edition published new progress about Autocatalysis. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application In Synthesis of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Banga, Jaspreet; Nizami, Sobia; Slim, Jihad; Nagarakanti, Sandhya; Portilla, Mario; Swaminathan, Shobha published the artcile< Hepatitis C virus treatment response to ledipasvir/sofosbuvir among patients coinfected with HIV and HCV: Real world data in a black population>, HPLC of Formula: 58-97-9, the main research area is ledipasvir antiviral agent hepatitis C virus HIV.

Treatment of hepatitis C virus (HCV) infection for patients with human immunodeficiency virus (HIV) has improved with direct acting antivirals. However, outcomes among Black persons treated with ledipasvir/sofosbuvir (LDV/SOF) may be inferior to non-Blacks. We assessed responses to LDV/SOF in a cohort of Black HIV/HCV coinfected persons.Retrospective chart reviews were conducted for Black, genotype 1 (GT1), HIV/HCV coinfected patients treated with LDV/SOF at 3 hospitals in Newark, NJ between Jan. 2014 and July 2016. Data collected included demographics, HCV treatment history, treatment duration, and response.One hundred seventeen HIV/HCV coinfected Black patients started treatment with LDV/SOF but 5 had no follow-up data and 5 prematurely discontinued treatment (1 due to side effects). We included 107HIV/HCV coinfected patients who completed LDV/SOF at all 3 sites. The study population was 65% male, median age 58 years, 26% had cirrhosis, and 78% had GT1a. Thirty-one percent were treatment experienced but none with prior NS5a treatment. At baseline, median CD4 count was 680cells/mm, HIV viral load (VL) was <40copies/mL in 94% and median HCV VL was 2,257,403IU/mL. Twenty-nine percent of patients changed antiretroviral treatment before LDV/SOF treatment due to drug interactions. Six, 89, and 12 patients completed 8, 12, and 24 wk of LDV/SOF, resp. Overall sustained virol. response rate was 93% with 7 relapses.In this real-world cohort of Black, GT1, HIV/HCV coinfected patients, LDV/SOF had high sustained virol. response 12 wk post completion of treatment rate of 93%. This data supports the overall high efficacy of LDV/SOF in a historically difficult-to-treat patient population. Medicine (Philadelphia, PA, United States) published new progress about Antiviral agents. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, HPLC of Formula: 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Poudel, Pramod Prasad; Arimitsu, Kenji; Yamamoto, Kana published the artcile< Self-assembled ion-pair organocatalysis - asymmetric Baeyer-Villiger oxidation mediated by flavinium-cinchona alkaloid dimer>, Recommanded Product: (R)-tert-Butyl (5-oxotetrahydrofuran-3-yl)carbamate, the main research area is flavinium cinchona alkaloid dimer organocatalysis asym Baeyer Villiger oxidation.

An ion-pair catalyst generated by assembly of a chiral flavinium and a cinchona alkaloid dimer for use in asym. Baeyer-Villiger oxidation is presented. Ion-pair formation is essential for enhancing the catalytic activity and stereoselectivity. The catalyst is applicable to structurally diverse 3-substituted cyclobutanones, providing good to excellent enantioselectivities (up to 98 : 2 e.r.). This study provides the first example of self-assembly of a flavin derivative and a base to form a chiral reaction site that enables a highly stereoselective reaction to occur.

Chemical Communications (Cambridge, United Kingdom) published new progress about Baeyer-Villiger oxidation. 137105-97-6 belongs to class tetrahydrofurans, and the molecular formula is C9H15NO4, Recommanded Product: (R)-tert-Butyl (5-oxotetrahydrofuran-3-yl)carbamate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Cocq, Aurelien; Leger, Bastien; Noel, Sebastien; Bricout, Herve; Djedaini-Pilard, Florence; Tilloy, Sebastien; Monflier, Eric published the artcile< Anionic Amphiphilic Cyclodextrins Bearing Oleic Grafts for the Stabilization of Ruthenium Nanoparticles Efficient in Aqueous Catalytic Hydrogenation>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is oleic succinyl beta cyclodextrin ruthenium nanoparticle catalyst preparation; petrosource biosource unsaturated compound benzene furfural hydrogenation ruthenium catalyst.

Oleic succinyl β-cyclodextrin was proved to be efficient for the stabilization of ruthenium nanoparticles (NPs) in aqueous medium. The catalytic activity of these NPs was evaluated in the aqueous hydrogenation of petrosourced and biosourced unsaturated compounds such as benzene and furfural derivatives The catalytic system can be easily recycled and reused up to nine runs without any loss of activity and selectivity, demonstrating its robustness.

ChemCatChem published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Stokes, P. W.; Foster, S. P.; Casey, M. J. E.; Cocks, D. G.; Gonzalez-Magana, O.; de Urquijo, J.; Garcia, G.; Brunger, M. J.; White, R. D. published the artcile< An improved set of electron-THFA cross sections refined through a neural network-based analysis of swarm data>, Electric Literature of 97-99-4, the main research area is alpha tetrahydrofurfuryl alc electron transport neural network simulation.

We review exptl. and theor. cross sections for electron transport in α-tetrahydrofurfuryl alc. (THFA) and, in doing so, propose a plausible complete set. To assess the accuracy and self-consistency of our proposed set, we use the pulsed-Townsend technique to measure drift velocities, longitudinal diffusion coefficients, and effective Townsend first ionization coefficients for electron swarms in admixtures of THFA in argon, across a range of d.-reduced elec. fields from 1 to 450 Td. These measurements are then compared to simulated values derived from our proposed set using a multi-term solution of Boltzmann’s equation. We observe discrepancies between the simulation and experiment, which we attempt to address by employing a neural network model that is trained to solve the inverse swarm problem of unfolding the cross sections underpinning our exptl. swarm measurements. What results from our neural network-based anal. is a refined set of electron-THFA cross sections, which we confirm is of higher consistency with our swarm measurements than that which we initially proposed. We also use our database to calculate electron transport coefficients in pure THFA across a range of reduced elec. fields from 0.001 to 10 000 Td. (c) 2021 American Institute of Physics.

Journal of Chemical Physics published new progress about Anodes. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Electric Literature of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hirayama, Thawinda; Kumar, Amit; Takada, Kenji; Kaneko, Tatsuo published the artcile< Morphology-Controlled Self-Assembly and Synthesis of Biopolyimide Particles from 4-Amino-L-phenylalanine>, Quality Control of 4415-87-6, the main research area is morphol selfassembly biopolyimide particle aminophenylalanine.

Self-assembling polyimides (PIs) having diketopiperazine (DKP) components were synthesized by polycondensation of a 4-amino-L-phenylalanine (4APhe) dimer, an aromatic diamine newly designed in this study. The amino acid-derived PIs showed high thermal resistance, with a 10% weight loss temperature (Td10) of 432°C at the maximum, and did not show any glass transition below the thermal decomposition temperature The poly(amic acid) (PAA) precursors formed nanospheres upon reprecipitation over dimethylacetamide into water. The nanospheres were then added to solvents with different polarities and sonicated to induce deformation of the spherical forms into spiky balls, flakes, or rods. The PAA particle morphologies were retained in the PIs after the two-step imidization. Finally, the PI particles with self-assembling DKP moieties were formed, and their morphologies were fine-tuned using different mixed solvents.

ACS Omega published new progress about Imidation. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Quality Control of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Vieux, Karl-Frederic; Prothro, Katherine P.; Kelley, Leanne H.; Palmer, Cameron; Maine, Eleanor M.; Veksler-Lublinsky, Isana; McJunkin, Katherine published the artcile< Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans>, Application of C9H13N2O9P, the main research area is microRNA TUT4 TUT7 CDE1 Candida.

MicroRNAs are frequently modified by addition of untemplated nucleotides to the 3′ end, but the role of this tailing is often unclear. Here we characterize the prevalence and functional consequences of microRNA tailing in vivo, using Caenorhabditis elegans. MicroRNA tailing in C. elegans consists mostly of mono-uridylation of mature microRNA species, with rarer mono-adenylation which is likely added to microRNA precursors. Through a targeted RNAi screen, we discover that the TUT4/TUT7 gene family member CID-1/CDE-1/PUP-1 is required for uridylation, whereas the GLD2 gene family member F31C3.2-here named GLD-2-related 2 (GLDR-2)-is required for adenylation. Thus, the TUT4/TUT7 and GLD2 gene families have broadly conserved roles in miRNA modification. We specifically examine the role of tailing in microRNA turnover. We determine half-lives of microRNAs after acute inactivation of microRNA biogenesis, revealing that half-lives are generally long (median = 20.7 h), as observed in other systems. Although we observe that the proportion of tailed species increases over time after biogenesis, disrupting tailing does not alter microRNA decay. Thus, tailing is not a global regulator of decay in C. elegans. Nonetheless, by identifying the responsible enzymes, this study lays the groundwork to explore whether tailing plays more specialized context- or miRNA-specific regulatory roles.

Nucleic Acids Research published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (GLD2). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sunyol, C.; English Owen, R.; Gonzalez, M. D.; Salagre, P.; Cesteros, Y. published the artcile< Catalytic hydrogenation of furfural to tetrahydrofurfuryl alcohol using competitive nickel catalysts supported on mesoporous clays>, Name: (Tetrahydrofuran-2-yl)methanol, the main research area is catalyst hydrogenation furfural tetrahydrofurfuryl alc nickel supported mesoporous clay.

Nickel catalysts supported on mesoporous clays with different acid properties, such as montmorillonite MK-10, Al-pillared montmorillonite, mesoporous Na-saponite and mesoporous H-saponite, were prepared, characterized and tested for the hydrogenation of furfural to tetrahydrofurfuryl alc. (THFA). Clays were also modified introducing basicity through magnesium oxide in different amounts Catalysts with higher acidity or low amounts of metallic centers favored deactivation and/or selectivity to the non-desired products. Interestingly, the addition of MgO both neutralized the acidity of the montmorillonite supports and improved the hydrogenation of the furanic ring, resulting in higher selectivity to THFA. The best catalyst was the one prepared with montmorillonite MK-10 covered by 30 wt% of magnesium oxide and with 8.8% of the Ni metal phase achieving total conversion and total selectivity to THFA. The activity of this catalyst was maintained after several reuses.

Applied Catalysis, A: General published new progress about Acidity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Name: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem