Ghobrial, Carolyne; Sobhy, Rodina; Mogahed, Engy; Abdullatif, Hala; El-Karaksy, Hanaa published the artcile< Is sofosbuvir/ledipasvir safe for the hearts of children with hepatitis C virus>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is hepatitis C virus infection heart sofosbuvir ledipasvir safety child; Bradycardia; ECG; HCV; Sofosbuvir.
Symptomatic bradycardia has been reported in adults treated for chronic hepatitis C using sofosbuvir based regimens.We studied the cardiac safety of sofosbuvir/ledipasvir in Egyptian children, treated for chronic hepatitis C. The study included 40 hepatitis C virus infected children and adolescents 12-17 years old, using the combination of sofosbuvir (400 mg)/ledipasvir (90 mg) in a single oral tablet (Harvoni) taken daily for 12 wk. All subjects underwent a baseline standard 12-lead surface Electrocardiog. that was repeated at 4 and 12 wk of therapy. Electrocardiog. parameters (Heart Rate, RR interval, PR interval, QRS, QT interval, corrected QT interval, QT dispersion, JT interval, corrected JT interval, JT dispersion, Tpeak-Tend interval) were compared at the 3 different time points during antiviral therapy.No symptoms related to the cardiovascular system were reported during treatment. There were no cases of symptomatic bradycardia/syncope. Heart rate was noted to be significantly lower and RR and QT intervals were significantly longer in the baseline electrocardiog. Heart rate was significantly lower and RR interval was significantly longer in patients with higher viral load.No adverse cardiovascular events were observed in this group of HCV infected children and adolescents treated with sofosbuvir/ledipasvir. None of the patients developed bradyarrhythmias during treatment.
Digestive and Liver Disease published new progress about Adolescent, mammalian. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem