Tal, Nitzan; Morehouse, Benjamin R.; Millman, Adi; Stokar-Avihail, Avigail; Avraham, Carmel; Fedorenko, Taya; Yirmiya, Erez; Herbst, Ehud; Brandis, Alexander; Mehlman, Tevie; Oppenheimer-Shaanan, Yaara; Keszei, Alexander F. A.; Shao, Sichen; Amitai, Gil; Kranzusch, Philip J.; Sorek, Rotem published the artcile< Cyclic CMP and cyclic UMP mediate bacterial immunity against phages>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is Pycsar; anti-phage; bacteria; cCMP; cUMP; cyclase; defense; pb8; phage; pyrimidine.
The cyclic pyrimidines 3′,5′-cyclic cytidine monophosphate (cCMP) and 3′,5′-cyclic uridine monophosphate (cUMP) have been reported in multiple organisms and cell types. As opposed to the cyclic nucleotides 3′,5′-cyclic adenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP), which are second messenger mols. with well-established regulatory roles across all domains of life, the biol. role of cyclic pyrimidines has remained unclear. Here we report that cCMP and cUMP are second messengers functioning in bacterial immunity against viruses. We discovered a family of bacterial pyrimidine cyclase enzymes that specifically synthesize cCMP and cUMP following phage infection and demonstrate that these mols. activate immune effectors that execute an antiviral response. A crystal structure of a uridylate cyclase enzyme from this family explains the mol. mechanism of selectivity for pyrimidines as cyclization substrates. Defense systems encoding pyrimidine cyclases, denoted here Pycsar (pyrimidine cyclase system for antiphage resistance), are widespread in prokaryotes. Our results assign clear biol. function to cCMP and cUMP as immunity signaling mols. in bacteria.
Cell (Cambridge, MA, United States) published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem