Day: October 14, 2022

Li, Xinsheng; Pang, Jifeng; Luo, Wenhao; Zhao, Yu; Pan, Xiaoli; Zheng, Mingyuan published the artcile< Catalytic Conversion of Tetrahydrofurfuryl Alcohol over Stable Pt/MoS2 Catalysts>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is platinum molybdenum disulfide catalyst tetrahydrofurfuryl alc hydrogenation.

MoS2 supported noble metal catalysts were used for the catalytic conversion of terahydrofurfuryl alc. (THFA) to 1,5-pentanediol (1,5-PDO) and its derivate tetrahydropyrane (THP). Over the optimal 4%Pt/MoS2-FR catalyst, 75.8% overall selectivity (35.4% to 1,5-PDO and 40.4% to THP) and 63.7% conversion of 5 wt% THFA solution were obtained after 8 h reaction at 250°C. The catalyst showed stable catalytic performance in five-cycle reactions, demonstrating the robustness of Pt/MoS2 under the harsh hydrothermal and hydrogenation conditions. A variety of characterizations, including CO-DRIFTS, HRTEM, H2-TPR, Raman spectroscopy and XPS revealed that typical behavior of strong metal-support interaction (SMSI) existed between Pt and MoS2, largely caused by the coverage of MoS2 over Pt and rarely reported previously. The Pt/MoS2 had intact structure under the harsh conditions thanks to the SMSI and chem. stability of MoS2. The acidity of Pt/MoS2 was negligible, and the active sites for the reaction were attributed to Pt and the Mo sites interacting closely on the catalysts. The reaction pathway was proposed according to the product distributions and the results of conditional experiments

Catalysis Letters published new progress about Acidity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brown, David W.; Mahon, Mary F.; Ninan, Aleyamma; Sainsbury, Malcolm published the artcile< Synthesis and oxidative behavior of reduced indeno[1,2-b]quinoxalines and benzo[b]phenazines>, Formula: C8H14O2, the main research area is quinoxaline tetracyclic preparation oxidation.

New routes to tetracyclic quinoxalines have been explored and their oxidative behavior has been examined Only if such compounds are devoid of benzylic hydrogen atoms are the corresponding cation radicals stable. Attempts to prepare certain polymethylated quinoxalines failed because of steric problems, and evidence is presented to show that in the case of some monohydrochloride salts proton migration between two nitrogen atoms is discernable through 1H NMR spectroscopy.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Heterocyclization. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Formula: C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Tierney, Amber R; Huepfel, William; Shaukat, Aasma P; Lake, John R; Boldt, Mark; Wang, Qi; Hassan, Mohamed A published the artcile< Direct-Acting Antiviral Therapy for Hepatitis C Infection in a Large Immigrant Community.>, Application of C9H13N2O9P, the main research area is Antiviral; Cirrhosis; Ethnicity; Hepatitis C.

Hepatitis C treatment has rapidly evolved with the arrival of direct-acting antiviral therapy. Sustained virologic response (SVR) rates in clinical trials are high but it is unknown how this translates to the immigrant community. Data from December 2013 to September 2015 was collected from a Midwest academic and community practice with a large immigrant population. There were 802 patients with an overall SVR rate of 88%. Ledipasvir/sofosbuvir was associated with favorable response among genotype 1 and 4 patients compared to other regimens (p < 0.001 and p = 0.05). Factors associated with treatment failure included advanced liver disease, male gender, East African/Middle Eastern ethnicity, and non-compliance. Patients with genotype 4 had lower SVR rates than other genotypes (58% vs. 89%, p < 0.001), particularly among East Africans (40% vs. 82% for other ethnicities). Our SVR rate for genotype 4 infection is lower than clinical trials and may be related to cultural, biologic and socioeconomic factors. Journal of immigrant and minority health published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

de la Lande, Aurelien; Denisov, Sergey; Mostafavi, Mehran published the artcile< The mystery of sub-picosecond charge transfer following irradiation of hydrated uridine monophosphate>, Application In Synthesis of 58-97-9, the main research area is uridine monophosphate electron transfer mechanism kinetics free energy.

The early mechanisms by which ionizing rays damage biol. structures by so-called direct effects are largely elusive. In a recent picosecond pulse radiolysis study of concentrated uridine monophosphate solutions [J. Ma, S. A. Denisov, J.-L. Marignier, P. Pernot, A. Adhikary, S. Seki and M. Mostafavi, J. Phys. Chem. Lett., 2018, 9, 5105], unexpected results were found regarding the oxidation of the nucleobase. The signature of the oxidized nucleobase could not be detected 5 ps after the electron pulse, but only the oxidized phosphate, raising intriguing questions about the identity of charge-transfer mechanisms that could explain the absence of U+. We address here this question by means of advanced first-principles atomistic simulations of solvated uridine monophosphate, combining D. Functional Theory (DFT) with polarizable embedding schemes. We contrast three very distinct mechanisms of charge transfer covering the atto-, femto- and pico-second timescales. We first investigate the ionization mechanism and subsequent hole/charge migrations on a timescale of attoseconds to a few femtoseconds under the frozen nuclei approximation We then consider a nuclear-driven phosphate-to-oxidized-nucleobase electron transfer, showing that it is an uncompetitive reaction channel on the sub-picosecond timescale, despite its high exothermicity and significant electronic coupling. Finally, we show that non-adiabatic charge transfer is enabled by femtosecond nuclear relaxation after ionization. We show that electronic decoherence and the electronic coupling strength are the key parameters that determine the hopping probabilities. Our results provide important insight into the interplay between electronics and nuclear motions in the early stages of the multiscale responses of biol. matter subjected to ionizing radiation.

Physical Chemistry Chemical Physics published new progress about Band gap. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application In Synthesis of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Bratkovic, Tomaz; Bozic, Janja; Rogelj, Boris published the artcile< Functional diversity of small nucleolar RNAs>, Safety of ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is review snoRNA posttranscription processing.

A review. Small nucleolar RNAs (snoRNAs) are short non-protein-coding RNAs with a long-recognized role in tuning ribosomal and spliceosomal function by guiding ribose methylation and pseudouridylation at targeted nucleotide residues of ribosomal and small nuclear RNAs, resp. SnoRNAs are increasingly being implicated in regulation of new types of post-transcriptional processes, for example rRNA acetylation, modulation of splicing patterns, control of mRNA abundance and translational efficiency, or they themselves are processed to shorter stable RNA species that seem to be the principal or alternative bioactive isoform. Intriguingly, some display unusual cellular localization under exogenous stimuli, or tissue-specific distribution. Here, we discuss the new and unforeseen roles attributed to snoRNAs, focusing on the presumed mechanisms of action. Furthermore, we review the exptl. approaches to study snoRNA function, including high resolution RNA:protein and RNA:RNA interaction mapping, techniques for analyzing modifications on targeted RNAs, and cellular and animal models used in snoRNA biol. research.

Nucleic Acids Research published new progress about Acetylation. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Safety of ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xu, Jiamin; Cui, Qianqian; Xue, Teng; Guan, Yejun; Wu, Peng published the artcile< Total Hydrogenation of Furfural under Mild Conditions over a Durable Ni/TiO2-SiO2 Catalyst with Amorphous TiO2 Species>, Reference of 97-99-4, the main research area is total hydrogenation furfural mild condition durable nickel titania silica.

One-step total hydrogenation of furfural (FAL) toward tetrahydrofurfuryl alc. in continuous flow using cheap transition metals still remains a great challenge. We herein reported the total hydrogenation of FAL over Ni (~5 nm) nanoparticles loaded on TiO2-SiO2 composites with long-term stability. The TiO2-SiO2 composites comprise amorphous TiOx which was grafted on the silica aerogel by acetyl acetone-aided controlled hydrolysis of tetra-Bu titanate. The catalysts were characterized by several techniques including Brunauer-Emmett-Teller, X-ray diffraction, transmission electron microscopy, H2-temperature-programmed reduction, and H2-temperature-programmed desorption. The hydrogenation performances were systematically explored in terms of TiO2 content, Ni loading, liquid hour space velocity, and so forth. Ni nanoparticles in contact with amorphous TiOx showed strengthened interaction with the C=O bond of FAL as well as enhanced hydrogen dissociation and desorption ability, hence benefiting the overall hydrogenation process.

ACS Omega published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Reference of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem