Day: October 14, 2022

Wu, Jingcheng; Zhang, Xinghua; Chen, Qiang; Chen, Lungang; Liu, Qiying; Wang, Chenguang; Ma, Longlong published the artcile< One-Pot Hydrogenation of Furfural into Tetrahydrofurfuryl Alcohol under Ambient Conditions over PtNi Alloy Catalyst>, Product Details of C5H10O2, the main research area is furfural one pot hydrogenation tetrahydrofurfuryl alc platinum nickel alloy.

Furfural (FAL), a promising renewable platform compound from biomass, can be totally hydrogenated to an industrially important platform chem., tetrahydrofurfuryl alc. (THFA). In this work, a high yield of THFA was obtained by one-pot hydrogenation of FAL over a PtNi catalyst under mild reaction conditions. Small PtNi alloy particles were well distributed on active carbon. The catalysts were characterized by several phys.-chem. technologies (transmission electron microscopy, X-ray diffraction, energy-dispersive spectroscopy, and inductively coupled plasma spectroscopy). Temperature-programmed reduction with hydrogen and in situ XPS demonstrate the presence of PtNi alloy. The electron-rich metal Pt could facilitate the heterolytic dissociation of hydrogen and promote the hydrogenation of FAL. Pt sites on the surface facilitate the adsorption at aldehyde (C=O) groups, and the furan ring strongly adsorbs on the Ni surface. Low reaction temperature is advantageous to reduce side reactions. Various metal concentrations were employed in this reaction; Pt(3)Ni(3)/C catalyst exhibits the best performance, achieving 99% FAL conversion and 93% THFA yield at 35°C and under 2 MPa H2.

Energy & Fuels published new progress about Hydrogenation catalysts. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wanderley, Ricardo R.; Pinto, Diego D. D.; Knuutila, Hanna K. published the artcile< Investigating opportunities for water-lean solvents in CO2 capture: VLE and heat of absorption in water-lean solvents containing MEA>, COA of Formula: C5H10O2, the main research area is flue gas carbon dioxide absorption water lean solvent; amine wet scrubbing carbon dioxide absorption; vapor liquid equilibrium water lean solvent carbon dioxide absorption; high volatility solvent carbon dioxide absorption; low volatility solvent carbon dioxide absorption.

A thorough study of a set of organic diluents for water-lean solvent formulation was conducted. Performance of 30 weight percent/weight aqueous monoethanolamine (MEA) 30 was compared to that of mixtures of 30 weight percent/weight MEA and methanol, acetone, monoethylene glycol (MEG), N-methyl-2-pyrrolidone (NMP), tetrahydrofurfuryl alc. (THFA), sulfolane, cyclopentanone (CC5), furfuryl alc., and γ-butyrolactone. A small calorimeter was used to obtain vapor-liquid equilibrium (VLE) and heat of absorption data. Shifting from aqueous to non-aqueous solvents had significant implications for VLE, since all water-lean solvents had lower CO2 solubility than aqueous MEA; however, heat of absorption was not much affected. Results showed the limitations of using most ethers, esters, and ketones for water-lean solvent formulation, all stemming from the very low dielec. permittivity of these diluents and the difficulty of stabilizing intermediate reaction species between MEA and CO2 within these systems. Nevertheless, the low volatility of solvents containing MEG, NMP, or THFA could offer opportunities for processes with overall less reboiler heat duties than that of ordinary aqueous MEA.

Separation and Purification Technology published new progress about Absorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, COA of Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hagens, Graham; Wasacz, John P.; Joullie, Madeleine; Yates, Peter published the artcile< Photolysis of 2,2,5,5-tetramethyldihydro-3-furanone>, SDS of cas: 5455-94-7, the main research area is furanones photolysis; photolysis furanones.

The photolysis of 2,2,5,5-tetramethyldihydro-3(2H)-furanone in MeOH gives Me 3-isopropoxy-3-methylbutanoate, Me 3-methyl-2-butenoate, iso-Pr 3-methyl-2-butenoate, Me 3-methyl-3-butenoate, and iso-PrOH. These products are all considered to arise via the ketene formed by Norrish type I cleavage of the dihydrofuranone followed by intramol. H abstraction. Corroboration for this view is that photolysis of 2,2,5,5-tetramethyldihydro-3(2H)-furanone-4-d2 in MeOH gives Me 3-(isopropoxy-2-d)-3-methylbutanoate and Me 3-methyl-2-butenoate-2-d.

Journal of Organic Chemistry published new progress about Photolysis. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, SDS of cas: 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Shibutani, Shotaro; Kodo, Taiga; Takeda, Mitsutaka; Nagao, Kazunori; Tokunaga, Norihito; Sasaki, Yusuke; Ohmiya, Hirohisa published the artcile< Organophotoredox-Catalyzed Decarboxylative C(sp3)-O Bond Formation>, Electric Literature of 97-99-4, the main research area is ether secondary amine thioether preparation; alc amine thiol dioxoisoindolinyl carboxylate photoredox decarboxylative coupling.

This manuscript reports a visible-light-mediated organosulfide catalysis that enables the decarboxylative coupling between simple aliphatic alc. and tertiary or secondary alkyl carboxylic acid-derived redox active esters to produce a C(sp3)-O-C(sp3) fragment. Results of the coupling using other heteroatom nucleophiles such as water, amides, and thiols are also described.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Electric Literature of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Guerra Romero, Adriana R; Pérez Figueras, Manuel; Alonso López, Sonia published the artcile< Successful evolution of morphea after hepatitis C virus eradication with direct-acting antiviral agent treatment.>, Category: tetrahydrofurans, the main research area is .

Hepatitis C virus infection has been associated with many dermatologic conditions such as lichen planus, porphyria cutanea tarda, and cryoglobulinemia. Recently, an association of HCV with systemic sclerosis has been reported. However, there are few reports of the association of localized scleroderma or morphea with Hepatitis C Virus infection. We describe the case of a 36 years old female patient suffering from prolonged morphea with difficult management, who was recently diagnosed of Hepatitis C Virus and received direct-acting antiviral agents treatment with Hepatitis C Virus clearance. Skin lesion faded away in a short period after successful therapy.

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Takada, Kenji; Shinagawa, Hiromasa; Morita, Yuki; Grewal, Manjit S.; Taya, Kazuya; Kumar, Amit; Kaneko, Tatsuo published the artcile< Syntheses of Soluble Biopolyimides Using 4-Aminophenylalanine>, Electric Literature of 4415-87-6, the main research area is aminophenylalanine tetracarboxylic dianhydride polyamic acid thermal imidization biopolyimide.

4-Aminophenylalanine (4APhe), an exotic amino acid which is obtained as a microorganism metabolite of glucose, is polycondensed with various tetracarboxylic dianhydrides as a diamine monomer to obtain poly(amic acid)s. Subsequent thermal imidization of poly(amic acid)s is made at 220°C with stepwise heating from 100°C. Some of the obtained polyimides (PIs) exhibited good solubility in organic solvents such as N,N-dimethylformamide, N,N-dimethylacetamide, and more. The progress of imidization was observed by proton NMR and IR spectroscopy to confirm that the imidization ratio was up to 98%. Carboxylate group of the side-chains of PIs affected their solubilities despite the high imidization ratio, and the solubility was lost for any organic solvents by decarboxylation at 280°C, confirmed from mass-loss of thermogravimetric anal. Thus, a new series of PIs were obtained with abilities of solvent-molding in PI state and thermal resistivity enhancement by further heating after molding.

Chinese Journal of Polymer Science published new progress about Glass transition temperature. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Electric Literature of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ishii, Hidenori; Tetsutani, Hisashi; Nagi, Tatsuya published the artcile< Improving liquid crystal alignment ability and UV sensitivity in photodecomposition polyimide film>, Reference of 4415-87-6, the main research area is carboxylic dianhydride liquid crystal UV sensitivity photodecomposition.

A liquid crystal alignment film with fewer processes capable of imparting anisotropy was developed using a polyimide, which utilized the cleavage of a cyclobutane ring by irradiation of polarized UV light at 254 nm. When an aromatic diamine with alkylene in the mol. center was used, an even methylene number of diamines showed superior liquid crystal alignment ability compared with diamines with an odd methylene number Addnl., a diamine containing a mol. structure with a pre-imidized imide group adjoined to a cyclobutane ring was extremely effective in improving liquid crystal alignment ability and sensitivity to polarized UV light.

Journal of Photopolymer Science and Technology published new progress about Anisotropy. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Reference of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Shao, Yuewen; Wang, Junzhe; Sun, Kai; Gao, Guoming; Li, Chao; Zhang, Lijun; Zhang, Shu; Xu, Leilei; Hu, Guangzhi; Hu, Xun published the artcile< Selective hydrogenation of furfural and its derivative over bimetallic NiFe-based catalysts: Understanding the synergy between Ni sites and Ni-Fe alloy>, Category: tetrahydrofurans, the main research area is furfural hydrogenation nickel iron catalyst synergistic effect.

Pentanediols (1,2-pentanediol and 1,5-pentanediol) are important feedstock for synthesis of fine chems., production of which from the biomass-derived furfural or furfuryl alc. (FA) has been considered as a sustainable route and attracted much interest. In this study, the catalysts with Ni-Fe as the metal sites and Mg-Al layered double hydroxides (LDH) as precursor of support were synthesized. The results showed that the presence of Fe in catalyst affected both the development of the pores of the catalyst and the catalytic behaviors of nickel species. A low Fe content facilitated formation of mesoporous structure, but the higher content destroyed the LDH structure, resulting in a decreased surface area. Fe could also react with metallic Ni to form NiFe alloy. This decreased the catalytic activity for the further hydrogenation of the furan ring in FA, and FA would thus have the chance to produce pentanediols via hydrogenolysis. The in-situ diffuse reflectance IR Fourier transform spectroscopy characterization of hydrogenation of FA indicated that the alloying between Fe and Ni resulted in a weak adsorption of C=C group in furan ring and moderate adsorption of C-O-C group, which suppressed the complete hydrogenation of FA while facilitated the ring-opening of FA to form the pentanediols.

Renewable Energy published new progress about Crystallinity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Noda, Takumi; Iwasaki, Takuma; Takada, Kenji; Kaneko, Tatsuo published the artcile< Soluble Biobased Polyimides from Diaminotruxinic Acid with Unique Bending Angles>, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is soluble bio polyimide diaminotruxinic acid bending solubility tensile thermal.

Biobased diamines with unique bending angles, β- and δ-type truxinic acids, were prepared from functionalized 4-nitrocinnamic acid derivatives via solid-state photodimerization and further chem. modification. The obtained diamines were polymerized with tetracarboxylic acid dianhydrides to produce soluble polyimides via chem. imidization at a high efficiency. The obtained δ-type-based polyimides exhibited a high thermostability at 10% weight loss temperature of ~415°C and good solubility in organic solvents. Most of the polyimides were soluble in chloroform and dichloromethane, as well as polar organic solvents. Tensile test results showed that biopolyimide films from cyclobutanetetracarboxylic dianhydride exhibited ~10.2% elongation at break, indicating high flexibility.

Macromolecules (Washington, DC, United States) published new progress about Crystal structure. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chandra, Anshuman; Gurjar, Vaishali; Qamar, Imteyaz; Singh, Nagendra published the artcile< Identification of potential inhibitors of SARS-COV-2 endoribonuclease (EndoU) from FDA approved drugs: a drug repurposing approach to find therapeutics for COVID-19>, Computed Properties of 58-97-9, the main research area is SARS COV2 endoribonuclease EndoU inhibitor drug repurposing; IC50; SARS-CoV-2; binding affinity; drug repurposing; endonuclease; molecular dynamic simulation.

SARS-CoV-2 is causative agent of COVID-19, which is responsible for severe social and economic disruption globally. Lack of vaccine or antiviral drug with clin. efficacy suggested that drug repurposing approach may provide a quick therapeutic solution to COVID-19. Nonstructural protein-15 (NSP15) encodes for an uridylate-specific endoribonuclease (EndoU) enzyme, essential for virus life cycle and an attractive target for drug development. We have performed in silico based virtual screening of FDA approved compounds targeting EndoU in search of COVID-19 drugs from com. available approved mols. Two drugs Glisoxepide and Idarubicin used for treatment for diabetes and leukemia, resp., were selected as stronger binder of EndoU. Both the drugs bound to the active site of the viral endonuclease by forming attractive intermol. interactions with catalytically essential amino acid residues, His235, His250, and Lys290. Mol. dynamics simulation studies showed stable conformation dynamics upon drugs binding to endoU. The binding free energies for Glisoxepide and Idarubicin were calculated to be -141±11 and -136±16kJ/mol, resp. The IC50 were predicted to be 9.2μM and 30μM for Glisoxepide and Idarubicin, resp. Comparative structural anal. showed the stronger binding of EndoU to Glisoxepide and Idarubicin than to uridine monophosphate (UMP). Surface area calculations showed buried are of 361.8 Å2 by Glisoxepide which is almost double of the area occupied by UMP suggesting stronger binding of the drug than the ribonucleotide. However, further studies on these drugs for evaluation of their clin. efficacy and dose formulations may be required, which may provide a quick therapeutic option to treat COVID-19. Communicated by Ramaswamy H. Sarma.

Journal of Biomolecular Structure and Dynamics published new progress about COVID-19. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Computed Properties of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem