Day: October 14, 2022

Morgado-Carrasco, Daniel; Combalia, Andrea; Fustà-Novell, Xavier; Mascaró, José Manuel Jr; Iranzo, Pilar published the artcile< Aggressive erosive lichen planus associated with hepatitis C responding to sofosbuvir/ledipasvir treatment.>, Synthetic Route of 58-97-9, the main research area is .

There is no abstract available for this document.

Indian journal of dermatology, venereology and leprology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Synthetic Route of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Popov, Yu. V.; Mokhov, V. M.; Nebykov, D. N.; Shirkhanyan, P. M.; Gendler, T. A.; Shemet, V. V. published the artcile< Colloidal and Nanosized Catalysts in Organic Synthesis: XXIV. Study of Hydrogenation of Furan and Its Derivatives in the Presence of MgO-Supported Nickel and Cobalt Nanoparticles>, Category: tetrahydrofurans, the main research area is furan hydrogenation nickel nanocatalyst plug flow reactor.

The processes of hydrogenation of furan and its derivatives (2-methylfuran, furfuryl alc., and furfural) in plug-flow type reactor under atm. hydrogen pressure at 20-220°C in the presence of supported nickel nanoparticles prepared via chem. reduction have been investigated. It has been found that nickel nanoparticles supported on magnesium oxide surface are the most reactive and stable under the considered conditions. This catalyst allows the corresponding hydrogenation products with 100% yield and complete conversion of the substrate.

Russian Journal of General Chemistry published new progress about Furans Role: RCT (Reactant), RACT (Reactant or Reagent). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Byun, Mi Yeon; Lee, Man Sig published the artcile< Pt supported on hierarchical porous carbon for furfural hydrogenation>, HPLC of Formula: 97-99-4, the main research area is furfural hydrogenation hierarchical porous carbon platinum catalyst.

Hierarchical porous carbon (HPC) was prepared using colloidal silica of different sizes as a template, and used as a support for Pt nanoparticles. The Pt dispersion varied with the pore size and structure of the HPC supports. However, the measured Pt dispersions (70%-76%) suggested that this characteristic was not affected by the pore size distribution above a certain size. The activities of the prepared Pt/HPC catalysts for furfural hydrogenation were then investigated. The HPC supports with large pores allowed for greater contact between the Pt nanoparticles and reactants due to the high mass transfer rate, resulting in the highest furfural conversion and 1-pentanol selectivity. In contrast, the HPC supports with small pores exhibited higher furfuryl alc. selectivities. The effect of the solvent on furfural hydrogenation was also investigated, and it was found that the solubility of H2 in the solvent affected the furfural conversion and product selectivity.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Catalyst supports. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, HPLC of Formula: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Gupta, Mrityunjay; Levine, Samantha R.; Spitale, Robert C. published the artcile< Probing Nascent RNA with Metabolic Incorporation of Modified Nucleosides>, HPLC of Formula: 58-97-9, the main research area is .

Conspectus: The discovery of previously unknown functional roles of RNA in biol. systems has led to increased interest in revealing novel RNA mols. as therapeutic targets and the development of tools to better understand the role of RNA in cells. RNA metabolic labeling broadens the scope of studying RNA by incorporating of unnatural nucleobases and nucleosides with bioorthogonal handles that can be utilized for chem. modification of newly synthesized cellular RNA. Such labeling of RNA provides access to applications including measurement of the rates of synthesis and decay of RNA, cellular imaging for RNA localization, and selective enrichment of nascent RNA from the total RNA pool. Several unnatural nucleosides and nucleobases have been shown to be incorporated into RNA by endogenous RNA synthesis machinery of the cells. RNA metabolic labeling can also be performed in a cell-specific manner, where only cells expressing an essential enzyme incorporate the unnatural nucleobase into their RNA. Although several discoveries have been enabled by the current RNA metabolic labeling methods, some key challenges still exist: (i) toxicity of unnatural analogs, (ii) lack of RNA-compatible conjugation chemistries, and (iii) background incorporation of modified analogs in cell-specific RNA metabolic labeling. In this Account, we showcase work done in our laboratory to overcome these challenges faced by RNA metabolic labeling. To begin, we discuss the cellular pathways that have been utilized to perform RNA metabolic labeling and study the interaction between nucleosides and nucleoside kinases. Then we discuss the use of vinyl nucleosides for metabolic labeling and demonstrate the low toxicity of 5-vinyluridine (5-VUrd) compared to other widely used nucleosides. Next, we discuss cell-specific RNA metabolic labeling with unnatural nucleobases, which requires the expression of a specific phosphoribosyl transferase (PRT) enzyme for incorporation of the nucleobase into RNA. In the course of this work, we discovered the enzyme uridine monophosphate synthase (UMPS), which is responsible for nonspecific labeling with modified uracil nucleobases. We were able to overcome this background labeling by discovering a mutant uracil PRT (UPRT) that demonstrates highly specific RNA metabolic labeling with 5-vinyluracil (5-VU). Furthermore, we discuss the optimization of inverse-electron-demand Diels-Alder (IEDDA) reactions for performing chem. modification of vinyl nucleosides to achieve covalent conjugation of RNA without transcript degradation Finally, we highlight our latest endeavor: the development of mutually orthogonal chem. reactions for selective labeling of 5-VUrd and 2-vinyladenosine (2-VAdo), which allows for potential use of multiple vinyl nucleosides for simultaneous investigation of multiple cellular processes involving RNA. We hope that our methods and discoveries encourage scientists studying biol. systems to include RNA metabolic labeling in their toolkit for studying RNA and its role in biol. systems.

Accounts of Chemical Research published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, HPLC of Formula: 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Pan, Calvin Q.; Tiongson, Benjamin C.; Hu, Ke-Qin; Han, Steven-Huy B.; Tong, Myron; Chu, Danny; Park, James; Lee, Tai Ping; Bhamidimarri, Kalyan Ram; Ma, Xiaoli; Xiao, Pei Ying; Mohanty, Smruti R.; Wang, Dan published the artcile< Real-World Study on Sofosbuvir-based Therapies in Asian Americans With Chronic Hepatitis C>, Product Details of C9H13N2O9P, the main research area is sofosbuvir chronic hepatitis C treatment.

Limited data exist with regard to treatment outcomes in Asian Americans with chronic hepatitis C (CHC). We evaluated sofosbuvir (SOF)-based regimens in a national cohort of Asian Americans. Eligible Asian Americans patients with CHC who had posttreatment follow-up of 24 wk for SOF -based therapies from Dec. 2013 to June 2017 were enrolled from 11 sites across the United States. The primary endpoint was sustained virol. response (SVR) rates at posttreatment weeks 12 and 24. Secondary endpoints were to evaluate safety by tolerability and adverse events (AEs). Among 231 patients screened, 186 were enrolled. At baseline, 31% (57/186) patients were cirrhotic, 34% (63/186) were treatment experienced. Most of the subjects (42%, 79/186) received ledispavir/SOF therapy. The overall SVR%, ran12 was 95ging from 86% in genotype (GT) 1b on SOF+ribavirin to 100% in GT 1b patients on ledipasvir/SOF at subgroup analyses. SVR12 was significantly lower in cirrhotic than in noncirrhotic patients [88% (50/57) vs. 98% (126/129), P<0.01]. Stratified by GT, SVR12 were: 96% (43/45) in GT 1a; 93% (67/72) in GT 1b; 100% (23/23) in GT 2; 90% (19/21) in GT 3; 100% (1/1) in GT 4; 83% (5/6) in GT 5; and 100% (16/16) in GT 6. Cirrhotic patients with treatment failure were primarily GT 1, (GT 1a, n = 2; GT 1b, n = 4) with 1 GT 5 (n = 1). Patients tolerated the treatment without serious AEs. Late relapse occurred in 1 patient after achieving SVR12. In Asian Americans with CHC, SOF-based regimens were well tolerated without serious AEs and could achieve high SVR12 regardless of hepatitis C viral infection GT. Journal of Clinical Gastroenterology published new progress about Chronic hepatitis C. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Taylor, Martin J.; Beaumont, Simon K.; Islam, Mohammed J.; Tsatsos, Sotirios; Parlett, Christopher A. M.; Issacs, Mark A.; Kyriakou, Georgios published the artcile< Atom efficient PtCu bimetallic catalysts and ultra dilute alloys for the selective hydrogenation of furfural>, Reference of 97-99-4, the main research area is atom PtCu bimetallic catalyst dilute alloy hydrogenation furfural.

A range of Pt:Cu bimetallic nanoparticles were investigated for the liquid-phase selective hydrogenation of furfural, an important platform biomass feedstock. Alloying of the two metals had a profound effect on the overall catalytic activity, providing superior rates of reaction and achieving the needed high selectivity towards furfuryl alc. Furthermore, we investigated the catalytic activity of an Ultra Dilute Alloy (UDA) formed via the galvanic replacement of Cu atoms by Pt atoms on dispersed host Cu nanoparticles (at. ratio Pt:Cu 1:20). This UDA, after overcoming an induction period, exhibits exceptionally high initial rates of hydrogenation under modest hydrogen pressures of 10 and 20 bar, rivalling the catalytic turnover for the monometallic Pt (containing 12 times more Pt), and outdoing the pure Cu or other compositions of bimetallic nanoparticle alloy catalysts. These atom efficient catalysts are ideal candidates for the valorization of furfural due to their activity and vastly greater economic viability.

Applied Catalysis, B: Environmental published new progress about Hydrogenation catalysts. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Reference of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Jasiobedzki, Wieslaw; Wozniak-Kornacka, Janina published the artcile< Electron spectra and synthesis of some α-tetrahydrofurandiones and -diols with phenyl and tert-butyl substituents in 2,5 positions>, Reference of 5455-94-7, the main research area is hydration tetrahydrofurandione UV; tetrahydrofuranone UV hydration; furandiol tetrahydro UV.

The effect of hydration on the UV spectra of α-diones I (R = R1 = R2 = R3 = Me; R = R2 = Ph, R1 = R3 = Me3C; R = R1 = R2 = Ph, R3 = CMe3; R = R1 = R2 = R3 = Ph) was compared to that on similarly structured tetrahydrofuranones, e.g., II. The UV spectrum of 3,4-tetrahydrofurandiols and 3-tetrahydrofuranols were determined

Bulletin de l’Academie Polonaise des Sciences, Serie des Sciences Chimiques published new progress about Hydration reaction. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Reference of 5455-94-7.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chen, Xiaozhen; Wu, Youjia; Huang, Liying; Yang, Lijuan; Hong, Ruixia; Yao, Hong; Li, Shaoguang published the artcile< Magnetic dispersive solid-phase micro-extraction combined with high-performance liquid chromatography for determining nucleotides in Anoectochilus roxburghii (Wall.) Lindl>, Related Products of 58-97-9, the main research area is magnetic dispersive solid phase microextraction HPLC Anoectochilus nucleotide; Anoectochilus roxburghii (Wall.) Lindl; Fe(3)O(4)@GO nano-adsorbent; High-performance liquid chromatography (HPLC); Magnetic dispersive solid-phase micro-extraction; Nucleotides; Sample pretreatment.

A novel, simple, and efficacious anal. method for determining of nucleotides in Anoectochilus roxburghii (Wall.) Lindl (A. roxburghii) was developed. Magnetic dispersive solid-phase micro-extraction (MDSPME) combined with high-performance liquid chromatog. was applied for extraction and determination of three nucleotides, such as adenosine-5′-monophosphate (AMP), uridine-5′-monophosphate (UMP) and guanosine-5′-monophosphate (GMP) in A. roxburghii from different sources. The structure and morphol. of magnetic nanoparticles, Fe3O4@GO, were illustrated by Fourier-transform IR (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and Thermagravimetric anal. (TGA) techniques. The effects of different extraction conditions on extraction efficiency were investigated and optimized. The optimum extraction conditions were performed as follows: 40.0 mg Fe3O4@GO were dispersed in 30 mL adsorption solution (pH 3.50, 2 μg/mL), 50 mM NaOH was employed for elution with 12 min of ultra-sonication at 40 °C. Under the aforementioned extraction conditions, the Fe3O4@GO nano-adsorbent obtained an excellent adsorption property. The corresponding linearity range for all three analytes exhibited a good linearity (r2 ≥ 0.9982) and notable added recoveries ranging from 88.4% to 109.8%, whereas the limit of quantitation was between 0.8-8 ng/mL. The enrichment factors (EF) were between 174 and 255. The proposed method showed the advantages of full purification, high EF, simplicity, and good recovery. The method was also successfully applied to nucleotides extraction and determination in A. roxburghii, showing superior reproducibility and high sensitivity. Based on this, the method could be expected to provide a novel exptl. means and developmental direction for improving pretreatment and purification of nucleotides, reducing matrix effects as much as possible, in traditional Chinese medicinal materials or biol. specimens.

Journal of Pharmaceutical and Biomedical Analysis published new progress about Adsorption. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Related Products of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ramos, Ruben; Peixoto, Andreia F.; Arias-Serrano, Blanca I.; Soares, O. Salome G. P.; Pereira, Manuel F. R.; Kubicka, David; Freire, Cristina published the artcile< Catalytic Transfer Hydrogenation of Furfural over Co3O4-Al2O3 Hydrotalcite-derived Catalyst>, SDS of cas: 97-99-4, the main research area is transfer hydrogenation furfural cobalt alumina hydrotalcite catalyst.

The hydrogenation of furfural by catalytic hydrogen transfer to produce furfuryl alc. has been investigated over a series of mixed oxides derived from hydrotalcite catalysts. Three different catalysts containing Ni, Co and Zn phases on an Al-rich amorphous support were synthesized and characterized. The catalytic performances were evaluated in a batch stirred reactor using 2-propanol as a solvent and hydrogen donor, with Co3O4-Al2O3 showing the highest activity and selectivity to FA (74% yield; 97% selectivity). The effects of temperature (T=120-180°C) and reaction time (t=30 min-24 h) were also studied, reaching a FA maximum yield of 92% at 150°C after 24 h. The Co3O4-Al2O3 catalyst showed a loss of activity after the first run, which can be easily restored by a simple calcination treatment. The results establish a catalytic route to produce valuable furfuryl alc. over 3d-transition metal-based catalysts without any external hydrogen supply.

ChemCatChem published new progress about Biomass. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, SDS of cas: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hodgkinson, Alison; Wall, Clare; Wang, Wendan; Szeto, Ignatius M.; Ye, Wenhui; Day, Li published the artcile< Nucleotides: an updated review of their concentration in breast milk>, Product Details of C9H13N2O9P, the main research area is review nucleotide concentration breast milk; Clinical study; Colostrum; Mature milk; Nucleotides concentrations; Transition milk.

A review. Our knowledge about the complexity of human milk, in particular fatty acid, protein, and oligosaccharide profiles, has increased considerably in recent years. However, little attention has been paid to nucleotides, which account for ∼2% to 5% of the nonprotein nitrogen fraction of breast milk and provide important cellular and metabolism functions for the infant. We examined literature published in the past 25 years to provide an updated review of concentrations of nucleotides in breast milk across lactational stages in mothers around the world. The free mononucleotides found in highest concentrations in breast milk are, from highest to lowest in the order of CMP, UMP, and AMP, GMP, and IMP. Levels of nucleotides varied considerably amongst individual mothers and with stage of lactation. They could be further influenced by time of day and season and the mothers diet. Levels of free nucleotides varied between studies undertaken in different regions; however, in studies that measured total potentially available nucleotides levels, regional differences were not apparent. Some studies report higher amounts in colostrum and transition milk compared with mature milk, whereas other studies report the converse. Recently, clin. studies showed that there are benefits to supplement nucleotides in infant formula. Although comparing data in the literature remains a challenge because of different milk collection methodologies and measurement protocols used by different studies, the information may provide insights for designing of formula products for infant at different stages of development.

Nutrition Research (New York, NY, United States) published new progress about Colostrum. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem