Day: October 14, 2022

Kuang, Gaizhen; Lu, Hongtong; He, Shasha; Xiong, Hejian; Yu, Jie; Zhang, Qingfei; Huang, Yubin published the artcile< Near-Infrared Light-Triggered Polyprodrug/siRNA Loaded Upconversion Nanoparticles for Multi-Modality Imaging and Synergistic Cancer Therapy>, COA of Formula: C8H4O6, the main research area is IR light polyprodrug siRNA nanoparticle synergistic cancer therapy; combination therapy; drug delivery; multi-modality imaging; near-infrared; upconversion nanoparticles.

Stimuli-responsive nanosystems have been widely applied as effective modalities for drug/gene co-delivery in cancer treatment. However, precise spatiotemporal manipulations of drug/gene co-delivery, as well as multi-modality imaging-guided cancer therapy, still remain a daunting challenge. Here, multifunctional polyprodrug/siRNA loaded upconversion nanoparticles (UCNPs) are reported that combine computed tomog. (CT), magnetic resonance (MR), and upconversion luminescence (UCL) tri-modality imaging and near-IR (NIR) light-activated drug/gene on-demand delivery. The photoactivatable platinum(IV) (Pt(IV))-backbone polymers (PPt) and the siRNA targeting polo-like kinase 1 (Plk1) are loaded on the surface of polyethyleneimine (PEI)-coated UCNPs (PUCNP) to obtain the multifunctional polyprodrug/siRNA loaded UCNPs (PUCNP@Pt@siPlk1). The PUCNP@Pt@siPlk1 can be served as a ′nanotransducer′ to convert NIR light (980 nm) into local UV to visible light for the cleavage of photosensitive PPt, resulting in the simultaneous on-demand release of high toxic platinum(II) (Pt(II)) and siPlk1. Meanwhile, the PUCNP@Pt@siPlk1 has CT, T1-weighted MR, and UCL tri-modality imaging abilities. Based on these merits, PUCNP@Pt@siPlk1 displayed excellent synergistic therapeutic efficacy via image-guided and NIR light-activated platinum-based chemotherapy and RNA interfering in vitro and in vivo. Thus, this developed nanosystem with NIR light-controlled drug/gene delivery and multi-modality imaging abilities, will display great potential in combining chemotherapy and gene therapy.

Advanced Healthcare Materials published new progress about Antitumor agents. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, COA of Formula: C8H4O6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ito, Yasuhiro; Hirokawa, Mitsuyoshi; Hayashi, Toshitetsu; Kihara, Minoru; Onoda, Naoyoshi; Miya, Akihiro; Miyauchi, Akira published the artcile< Clinical outcomes of follicular tumor of uncertain malignant potential of the thyroid: real-world data.>, HPLC of Formula: 58-97-9, the main research area is Follicular tumor of uncertain malignant potential; Prognosis; Thyroid.

Thyroid tumors arising from follicular cells can generally be divided into malignant and benign tumors. However, some cases are difficult to clearly diagnose whether they are benign or malignant. Therefore, in the most recent version of World Health Organization (WHO) classification, some borderline lesions such as follicular tumor of uncertain malignant potential (FT-UMP), well-differentiated tumor of uncertain malignant potential (WDT-UMP), and noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) were proposed. In this study, we investigated the clinical aspects, including the prognosis, of FT-UMP patients. We investigated the clinical features of 339 patients with FT-UMP. On ultrasound, 68% of the tumors were diagnosed as intermediate, and only 5% of those tumors were diagnosed as malignant. On cytology, 40% of the tumors were diagnosed as follicular neoplasm, and only 1% of these were suspected to be or diagnosed as malignancy. The diagnosis was based on questionable capsular invasion for 332 patients, questionable vascular invasion for 2 patients, and both for 5 patients. Eighty-six percent of the tumors showed low cell proliferation activity. To date, five patients (1%) have shown distant recurrence during postoperative follow-up and underwent various treatments such as radioactive iodine therapy, orthopedic surgery, and denosumab injection. None of these patients have died due to thyroid carcinoma. Our findings suggest that FT-UMP is generally an indolent disease, but some patients show distant recurrence. Physicians should carefully follow patients, although it remains unknown how long they should be observed after surgery.

Endocrine journal published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, HPLC of Formula: 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Elbedewy, Tamer A; Abd-Elsalam, Sherief; Mostafa, Sahar Mohamed; Abdellatif, Raghda Samir; Fouad, Amina; Youssef, Mona; Abo-Amer, Yousry Esam-Eldin; Elsebaey, Mohamed A published the artcile< Sofosbuvir/Ledipasvir for Treatment of Chronic Hepatitis C Infection in Adult Patients with β- Thalassemia Major: A Real-Life Study.>, Reference of 58-97-9, the main research area is HCV; blood diseases; chronic liver disease; cirrhosis; sofosbuvir/ledipasvir; β- Thalassemia major.

BACKGROUND & AIMS: Patients with thalassemia have a lifelong need for blood transfusion, which makes them more risky to hepatitis C virus (HCV). Iron overload and chronic HCV are considered risk factors for patients with thalassemia to develop liver insults. The aim of the present study is to investigate the safety and efficacy of sofosbuvir/ledipasvir in the treatment of chronic HCV infection in Egyptian adult patients with β- thalassemia major. METHODS: A retrospective study included 53 patients with β-thalassemia major with chronic HCV treated with sofosbuvir (400 mg) and ledipasvir (90 mg) as a single pill fixed-dose combination once daily for 12 weeks. The effectiveness of the treatment was assessed by the sustained virologic response (SVR) at 12 weeks after the end of the treatment. RESULTS: SVR was achieved in 96.23% of patients. 47.17% of patients had minor side effects. There was a significant reduction in ALT, AST, and serum ferritin 12 weeks post-therapy. There was an insignificant change in hemoglobin level or blood transfusion requirement 12 weeks posttherapy. There was no change in iron chelators doses throughout the study period. CONCLUSION: Sofosbuvir/ledipasvir regimen seems to be safe and highly effective in the treatment of chronic HCV in patients with β-thalassemia major.

Endocrine, metabolic & immune disorders drug targets published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Reference of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

El-Araby, Hanaa A; Behairy, Behairy E; El-Guindi, Mohamed A; Adawy, Nermin M; Allam, Alif A; Sira, Ahmad M; Khedr, Mohamed A; Elhenawy, Ibrahim A; Sobhy, Gihan A; Basiouny, Hosam El Din M; Salem, Menan E; Abdel-Aziz, Samira A; Fouad, Ola A; Ayoub, Bassam A published the artcile< Generic sofosbuvir/ledipasvir for the treatment of genotype 4 chronic hepatitis C in Egyptian children (9-12 years) and adolescents.>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is Children; Hepatitis C virus; Ledipasvir; Sofosbuvir.

BACKGROUND/PURPOSE OF THE STUDY: Worldwide and national efforts are directed against eradication of HCV. The introduction of direct-acting antivirals (DAAs) has changed dramatically the outcome of HCV treatment. In spite of the Food and Drug Administration approval of the oral drugs sofosbuvir (SOF) and ledipasvir (LED) for the treatment of HCV in adolescents more than or equal to 12 years old, sufficient real-world experience is still lacking. The aim of this study was to assess the safety and efficacy of the generic SOF/LED fixed-dose combination 400/90 (400 mg SOF + 90 mg LED) for the treatment of adolescents and children (9-12 years) with chronic hepatitis C (CHC). METHODS: In this prospective observational study, 100 cases of genotype 4 CHC were recruited consecutively from those fulfilling the inclusion and exclusion criteria. All cases received the generic fixed-dose combination SOF/LED (400/90), one tablet daily for 12 weeks. All clinical, laboratory, and virologic characteristics were evaluated at base line, and week (W) 2, 4, 8, and 12 of therapy and W12 post-treatment (SVR12). RESULTS: Recruited children (9-12) and adolescents weighed 28-83 and 31-90 kg, respectively. Eighty cases were naïve and 20 cases were pegylated interferon/ribavirin treatment-experienced. Very rapid virologic response (vRVR) at W2 was 96%, while at W4 response rate was 100% and maintained till the end of treatment and at W12 post-treatment (SVR12). All reported side effects were mild and did not lead to treatment termination and disappeared at W12 post-treatment. CONCLUSION: The generic SOF/LED fixed-dose combination is safe and effective in children, 9-12 years, and adolescents with vRVR rate of 96%, 100% EOT response and SVR12.

Hepatology international published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Dandan; Wang, Chengyang; Ma, Shengqi; Zhou, Hongwei; Lu, Ran published the artcile< Preparation and characterization of soluble heat-resistant polyimide films containing bis-N-phenyl-benzimidazole>, Related Products of 4415-87-6, the main research area is polybenzimidazole imide heat resistant film thermomech property.

To prepare soluble polyimides with high temperature resistance, two new diamine monomers, namely, 2,2′-(4,4′-oxybisphenylene)-bis(1-phenyl-5-aminobenzimidazole) (5a), and 2,2′-(4,4′-hexafluoroisopropylidene)-bis(1-phenyl-5- aminobenzimidazole) (5b), were synthesized and exploited to prepare three series of poly(benzimidazole imides)s (PBIIs) by a conventional two-stage synthesis. The resulting PI films were flexible and tough, possessing high glass-transition temperatures (Tgs = 311°C-390°C), improved optical transparency, and excellent solubility Moreover, the effect of different configuration on performance was revealed, and these data provided a feasible method to enhance both Tg and solubility of PIs by incorporating N-Ph benzimidazole and corresponding functional moieties.

High Performance Polymers published new progress about Complex modulus, tan δ. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Related Products of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Dai, Kun; Peng, Xiaoqiang; Zhuang, Wei; Yang, Pengpeng; Jiao, Pengfei; Wu, Jinglan; Ying, Hanjie published the artcile< Mass transfer process and separation mechanism of four 5′-ribonucleotides on a strong acid cation exchange resin>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is 5′-ribonucleotides; Homogeneous surface diffusion model; Ion exchange chromatography; Mass transfer process; Physical adsorption; Separation mechanism.

5′-ribonucleotides including AMP (AMP), cytidine 5′-monophsphate (CMP), GMP (GMP) and UMP (UMP) have been widely used in the food and pharmaceutical industries. This work focused on the assessment of mass transfer process and separation mechanism of four 5′-ribonucleotides and counter-ion Na+ on the strong cation exchange resin NH-1. The intraparticle diffusion was determined as the rate-limiting step for the mass transfer of AMP, CMP, GMP, and Na+ on the resin NH-1 through the Boyd model. Meanwhile, a homogeneous surface diffusion model (HSDM) combing ion exchange and phys. adsorption was proposed and tested against adsorption kinetic data in the batch adsorption systems. The fixed-bed film-surface diffusion model based on the HSDM was then developed and successfully predicted the concentration profiles of 5′-ribonucleotides and the change of pH at the outlet of the fixed-bed in the dynamic adsorption and separation process. Finally, the separation mechanism of 5′-ribonucleotides was presented combining model prediction and exptl. results. The separation of UMP, GMP and CMP were mainly based on their differences in isoelec. points, while that of AMP and CMP were lied with the discrepancy of their phys. adsorption binding capacity with the resin NH-1.

Journal of Chromatography A published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lan, Jingmin; Liu, Peiwen; Fu, Ping; Liu, Xiaoling; Xie, Menglin; Jiang, Shi; Wen, Haimeng; Zhou, Yu; Wang, Jun published the artcile< Palladium confined in pure-silica TON zeolite for furfuryl alcohol hydrogenation into tetrahydrofurfuryl alcohol>, Formula: C5H10O2, the main research area is furfuryl alc hydrogenation palladium silica zeolite.

Fabrication of robust noble metal nanoparticles (NPs) usually suffers from instability due to the large surface energy of small particles. Herein, highly dispersive Pd nanoparticles (average size: ∼3 nm) with controllable content were directly encapsulated within pure silica zeolite matrix with TON topol. via a dry gel conversion pathway, in which 1-butyl-3-methylimidazolium bromide and (3-mercaptopropyl) trimethoxysilane were utilized as the structure-directing agent and metal stabilizer, resp. High crystallinity and large surface area were reached over this Pd containing zeolites. The champion catalyst Pd-Si-ZSM-22 effectively catalyzed the transformation of furfuryl alc. into tetrahydrofurfuryl alc. via hydrogenation by using H2. High conversion (>99%) and selectivity (>99%) were reached with large turnover numbers and the stable activity was observable during the recycling test. The comparison with the post-impregnated counterpart indicates that the straightforward synthesis is favorable for the construction of stable and robust Pd species within the confined microchannels of TON zeolites.

Microporous and Mesoporous Materials published new progress about Crystallinity. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Hassenkam, Tue; Deamer, David published the artcile< Visualizing RNA polymers produced by hot wet-dry cycling>, SDS of cas: 58-97-9, the main research area is RNA polymers hot wet dry cycling.

It is possible that the transition from abiotic systems to life relied on RNA polymers that served as ribozyme-like catalysts and for storing genetic information. The source of such polymers is uncertain, but previous investigations reported that wet-dry cycles simulating prebiotic hot springs provide sufficient energy to drive condensation reactions of mononucleotides to form oligomers and polymers. The aim of the study reported here was to verify this claim and visualize the products prepared from solutions composed of single mononucleotides and 1:1 mixture of two mononucleotides. Therefore, we designed experiments that allowed comparisons of all such mixtures representing six combinations of the four mononucleotides of RNA. We observed irregular stringy patches and crystal strands when wet-dry cycling was performed at room temperature (20°C). However, when the same solutions were exposed to wet-dry cycles at 80°C, we observed what appeared to be true polymers. Their thickness was consistent with RNA-like products composed of covalently bonded monomers, while irregular strings and crystal segments of mononucleotides dried or cycled at room temperature were consistent with structures assembled and stabilized by weak hydrogen bonds. In a few instances we observed rings with short polymer attachments. These observations are consistent with previous claims of polymerization during wet-dry cycling. We conclude that RNA-like polymers and rings could have been synthesized non-enzymically in freshwater hot springs on the prebiotic Earth with sizes sufficient to fold into ribozymes and genetic mols. required for life to begin.

Scientific Reports published new progress about Crystallinity. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, SDS of cas: 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem