Lovey, Raymond G.; Saksena, Anil K.; Girijavallabhan, Vlyyoor M. published their research in Tetrahedron Letters on August 15 ,1994. The article was titled 《PPL-catalyzed enzymic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: improvements toward synthesis of the eutomers of SCH 45012》.Recommanded Product: 160709-02-4 The article contains the following contents:
Porcine pancreatic lipase catalysis has been used to establish both stereocenters of (tetrahydrofuranylmethyl)tosylate I. In addition to the enzymic differentiation of the hydroxyl groups of the pro-chiral 1,3-diol segment of triol (R)-II [R1 = CH(CH2OH)2], successful enzymic resolution of the racemic diol II (R1 = OH) provided an alternate route to the important precursor diol (R)-II (R1 = OH). In the experiment, the researchers used many compounds, for example, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Recommanded Product: 160709-02-4)
((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Recommanded Product: 160709-02-4
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem